DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and Tle3

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_006243273.1	Gene:	Tle3 / 84424	RGDID:	620292	Length:	782	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	74/353 - (20%)
Similarity:	134/353 - (37%)	Gaps:	85/353 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYS--- 77
            :|...|.::.:....|.:.|||:. .|.:|.|.|......::    .:||:.   :||::.|
  Rat   494 SHGEVVCAVTISNPTRHVYTGGKG-CVKIWDISQPGSKSPIS----QLDCLN---RDNYIRSCKL 550

  Fly    78 ---------ADDIGIIRRWDLNS--QKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDV 131
                     ..:...:..|||.|  .:|.:.|.....:...|..:|..:...|..:|..:.:||:
  Rat   551 LPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDL 615

  Fly   132 QNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQ 196
            .|: ..::..:||....:.:..|.||..:.:.||:.::..||:|:.:|:               |
  Rat   616 HNQ-TLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQL---------------Q 664

  Fly   197 FHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVG-SSSGISVI-G 259
            .|.|           |..|:.|.:                |.|    ||.|.|| .||.:.|: .
  Rat   665 QHDF-----------TSQIFSLGY----------------CPT----GEWLAVGMESSNVEVLHH 698

  Fly   260 WEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIPFYQPPNSLPNF--KHN 322
            .:||:...|:..  |.:..:|..    .||...:.|      ..|.::..::.|.....|  |.:
  Rat   699 TKPDKYQLHLHE--SCVLSLKFA----YCGKWFVST------GKDNLLNAWRTPYGASIFQSKES 751

  Fly   323 STNRKSFTRGNQKFRLSVGGAKPAQVQE 350
            |:........:.|:.::..|.|.|.|.|
  Rat   752 SSVLSCDISADDKYIVTGSGDKKATVYE 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	68/331 (21%)
		WD40	14..260	CDD:238121	55/259 (21%)
		WD40 repeat	22..58	CDD:293791	8/35 (23%)
		WD40 repeat	63..99	CDD:293791	10/49 (20%)
		WD40 repeat	106..142	CDD:293791	7/35 (20%)
		WD40 repeat	148..184	CDD:293791	9/35 (26%)
		WD40 repeat	192..228	CDD:293791	6/35 (17%)
		WD40 repeat	285..310	CDD:293791	4/24 (17%)
Tle3	XP_006243273.1	WD40 repeat	589..625	CDD:293791	7/36 (19%)
		WD40 repeat	632..667	CDD:293791	10/49 (20%)
		WD40 repeat	672..705	CDD:293791	14/52 (27%)
		WD40 repeat	713..747	CDD:293791	6/43 (14%)
		WD40 repeat	754..778	CDD:293791	4/23 (17%)
		TLE_N	9..143	CDD:397828
		Herpes_BLLF1	<261..482	CDD:282904
		WD40	494..779	CDD:238121	73/351 (21%)
		WD40 repeat	499..538	CDD:293791	9/43 (21%)
		WD40 repeat	546..584	CDD:293791	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910