DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kat80 and DWA3

DIOPT Version :10

Sequence 1:NP_523363.2 Gene:kat80 / 32581 FlyBaseID:FBgn0040207 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_176316.4 Gene:DWA3 / 842414 AraportID:AT1G61210 Length:1181 Species:Arabidopsis thaliana


Alignment Length:1194 Identity:252/1194 - (21%)
Similarity:421/1194 - (35%) Gaps:407/1194 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KIYDIKAHDSRVTSLDLG-ETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDN 73
            |:.:..||.:.|..|.:| :|.|:.:|||:|..|||||||:....|||.||..::|.|.|...:.
plant     7 KLQEFLAHSANVNCLSIGKKTSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEV 71

  Fly    74 FVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCI 138
            .|.:....|:|:.||:...|:.....||..:...::|:|.||::.|||:|..:::||:: :..||
plant    72 LVLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIR-KKGCI 135

  Fly   139 KVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEF-IADPPVTAITCVQFHPFEF 202
            :..:||...:::::|:|||.|:.|.||:..:.:||:...|.:.|| ..:.|:.::   .|||.||
plant   136 QTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKFHEGPIRSL---DFHPLEF 197

  Fly   203 LLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDRELD 267
            |||.|..|.||..:|||..:|:. :|......:|.|.|..:|..||.|....:.|..|||....|
plant   198 LLATGSADRTVKFWDLETFELIG-STRPEATGVRSIKFHPDGRTLFCGLDDSLKVYSWEPVVCHD 261

  Fly   268 HIKSTWSSLADMKVVNNKLICGC-HEIDTVSINTISLDRVIPF----------------YQPPNS 315
            .:...||:|.|:.:...||: || :..::|.|....:.::.|:                .....|
plant   262 GVDMGWSTLGDLCISEGKLL-GCSYYQNSVGIWVSDISQIEPYGIGSADKKECVEKILSALDDQS 325

  Fly   316 LPNFKHNSTNRKSFTRGNQKFRL------SVGGAKPAQVQEEHEGDKSG-LSSP---------NY 364
            ....|  ||.|:|.:...:...:      |.||....       ..||| ||:|         |.
plant   326 FDRIK--STPRRSSSPDYETKEIKNIYIDSTGGNSAV-------AHKSGSLSTPATSTGQAGDNK 381

  Fly   365 SLEVVNEAV-----------------LESAETSPMSSLPPVHLASMAGSSADLAPHHVVYG---- 408
            || ||:..|                 :..::|.|...|.|.::........:.....|..|    
plant   382 SL-VVHSVVPRDSDIGKDSSDSGKESITFSKTKPGMLLRPAYVRKTPTKFDETKKQSVAVGYLKK 445

  Fly   409 ------------GAIDS--------------------------------------ALRQGKYSRV 423
                        .|.||                                      .|:..:..|.
plant   446 SGLDGEKKLDTETAFDSEMSGRNPYDADDSIIKSITNKFEQALLPESPTDEAKCMLLKPPRVQRS 510

  Fly   424 PD---NMASYGSS--YGAIDTR------------------------------------------- 440
            |.   |.|.:.:|  .||:|::                                           
plant   511 PSTKYNEARWATSTDSGALDSKKNGLESSRDMDLPTGLRDDRGSNPCEEDIENKSISSRSERVLS 575

  Fly   441 -------LMSLNEPSS---------------------------------------------LHKP 453
                   |.||..|..                                             :|..
plant   576 PEKAGDELKSLESPGGSKESKSVKVVRGVKVVSGRTRSLVERFERGEKITHSEDKAASATVVHSS 640

  Fly   454 DIYNLYPLD----------------KNEEA------DVQQLEFNLNDSNP----PILNNYDNYEM 492
            :.....||.                |.::|      ||..|......|.|    |::...|. .|
plant   641 NSVEEEPLTASVQTVSMMPTQVMPVKLDQATNSTTVDVPVLSTRRTKSTPVRVMPVVLGRDT-SM 704

  Fly   493 AEDFP--------------VNQNLNYITNNYK----PVPATSTI---NASSKSIKKTTTTTLHKR 536
            |.|.|              :..:::.:|:..:    |.|....|   ....||.:.:.|:|...|
plant   705 ATDTPPVTSTRPDRTSATNLTSDVSGVTSKRQTRTSPAPVMPMILNQTTKMKSDEPSITSTWPDR 769

  Fly   537 T-----TNNMAGA-----KQTSTGIFGGSKLSQVSSVSSME------------------------ 567
            |     |::::|.     .:||.......||:|.:.:.|.|                        
plant   770 TSATDLTSDVSGVISSRQTRTSPAPVMPMKLNQKTKIKSDEPPITSTRPDRPSATNLTSDESPVT 834

  Fly   568 ----------------LH-------KLDDNMVLK----KSSSSNVV---------NKNKRPMGSA 596
                            |:       |.|:..|:.    ::||:.|:         ..::||:.|:
plant   835 STRQAKTSPAPVTPVILNQRQTTNMKSDEPPVISTRPLRTSSARVMPVILNQASTTYDERPLSSS 899

  Fly   597 QS----------------------------QFSKEN----------NQQKNIN------------ 611
            :|                            ..|..|          ||..|:.            
plant   900 RSARTSPARIMPMKLNQADNMPSYEPPVALTRSARNSPARVIPVKLNQATNVTADASHIRSRQRF 964

  Fly   612 --VEIITKPPMRSRTTLDMRTSHQAKTQEKQ---IHQQQP-MNNRIIMDDHD-FDMLSRSHEAVL 669
              .:.:..|.:..:.| ||......|||:..   ..:::| ::.|  .||.| :::|.|:|..||
plant   965 SPTQTLATPAVFDQVT-DMTLDETTKTQQSSDILTQKEEPQISGR--EDDGDIWEILMRTHSEVL 1026

  Fly   670 QELSNRQSSLDLLRHATRSHDVLGALRQARSCG-KSIFIDLLGAILEKPSSWNLDFCMFVLPEIY 733
            ..|.:|.:.|.::||.....|:.||:...|... .|:..|::..:.:|.....||....:.|.:.
plant  1027 NTLQSRLTKLQIVRHFWERSDIKGAIAALRKLSDHSVQADVINILTDKTEILTLDLFSQLAPVLT 1091

  Fly   734 ELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQI- 797
            .||.|:.:.....:.:.|..:::.|...||..:.  |...:|||:..|:|.:.|..|...|.:: 
plant  1092 GLLGSKTERPVNVSLEMLLKLVAVFGTVIQSTVS--ARRVVGVDLHAEERLQICQSCSAELQKVQ 1154

  Fly   798 KNLPESTHFGSTL---SQLQNIII 818
            |.||..|..|..:   :|..|:::
plant  1155 KILPLLTRRGGLIARKAQELNLVL 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kat80NP_523363.2 WD40 <11..263 CDD:441893 89/253 (35%)
WD40 repeat 22..58 CDD:293791 18/36 (50%)
WD40 repeat 63..99 CDD:293791 9/35 (26%)
WD40 repeat 106..142 CDD:293791 12/35 (34%)
WD40 repeat 148..184 CDD:293791 13/36 (36%)
WD40 repeat 192..228 CDD:293791 16/35 (46%)
WD40 repeat 285..310 CDD:293791 7/41 (17%)
Katanin_con80 663..817 CDD:464044 42/158 (27%)
DWA3NP_176316.4 WD40 8..260 CDD:238121 90/256 (35%)
WD40 repeat 19..56 CDD:293791 18/36 (50%)
WD40 repeat 61..97 CDD:293791 9/35 (26%)
WD40 repeat 104..139 CDD:293791 12/35 (34%)
WD40 repeat 145..181 CDD:293791 12/35 (34%)
WD40 repeat 187..222 CDD:293791 16/38 (42%)
WD40 repeat 229..252 CDD:293791 7/22 (32%)
Herpes_BLLF1 <670..>908 CDD:282904 42/238 (18%)
Katanin_con80 1020..1178 CDD:464044 42/159 (26%)

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