DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and DWA3

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_176316.4	Gene:	DWA3 / 842414	AraportID:	AT1G61210	Length:	1181	Species:	Arabidopsis thaliana

Alignment Length:	1194	Identity:	252/1194 - (21%)
Similarity:	421/1194 - (35%)	Gaps:	407/1194 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KIYDIKAHDSRVTSLDLG-ETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDN 73
            |:.:..||.:.|..|.:| :|.|:.:|||:|..|||||||:....|||.||..::|.|.|...:.
plant     7 KLQEFLAHSANVNCLSIGKKTSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEV 71

  Fly    74 FVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCI 138
            .|.:....|:|:.||:...|:.....||..:...::|:|.||::.|||:|..:::||:: :..||
plant    72 LVLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIR-KKGCI 135

  Fly   139 KVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEF-IADPPVTAITCVQFHPFEF 202
            :..:||...:::::|:|||.|:.|.||:..:.:||:...|.:.|| ..:.|:.::   .|||.||
plant   136 QTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKFHEGPIRSL---DFHPLEF 197

  Fly   203 LLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDRELD 267
            |||.|..|.||..:|||..:|:. :|......:|.|.|..:|..||.|....:.|..|||....|
plant   198 LLATGSADRTVKFWDLETFELIG-STRPEATGVRSIKFHPDGRTLFCGLDDSLKVYSWEPVVCHD 261

  Fly   268 HIKSTWSSLADMKVVNNKLICGC-HEIDTVSINTISLDRVIPF----------------YQPPNS 315
            .:...||:|.|:.:...||: || :..::|.|....:.::.|:                .....|
plant   262 GVDMGWSTLGDLCISEGKLL-GCSYYQNSVGIWVSDISQIEPYGIGSADKKECVEKILSALDDQS 325

  Fly   316 LPNFKHNSTNRKSFTRGNQKFRL------SVGGAKPAQVQEEHEGDKSG-LSSP---------NY 364
            ....|  ||.|:|.:...:...:      |.||....       ..||| ||:|         |.
plant   326 FDRIK--STPRRSSSPDYETKEIKNIYIDSTGGNSAV-------AHKSGSLSTPATSTGQAGDNK 381

  Fly   365 SLEVVNEAV-----------------LESAETSPMSSLPPVHLASMAGSSADLAPHHVVYG---- 408
            || ||:..|                 :..::|.|...|.|.::........:.....|..|
plant   382 SL-VVHSVVPRDSDIGKDSSDSGKESITFSKTKPGMLLRPAYVRKTPTKFDETKKQSVAVGYLKK 445

  Fly   409 ------------GAIDS--------------------------------------ALRQGKYSRV 423
                        .|.||                                      .|:..:..|.
plant   446 SGLDGEKKLDTETAFDSEMSGRNPYDADDSIIKSITNKFEQALLPESPTDEAKCMLLKPPRVQRS 510

  Fly   424 PD---NMASYGSS--YGAIDTR------------------------------------------- 440
            |.   |.|.:.:|  .||:|::
plant   511 PSTKYNEARWATSTDSGALDSKKNGLESSRDMDLPTGLRDDRGSNPCEEDIENKSISSRSERVLS 575

  Fly   441 -------LMSLNEPSS---------------------------------------------LHKP 453
                   |.||..|..                                             :|..
plant   576 PEKAGDELKSLESPGGSKESKSVKVVRGVKVVSGRTRSLVERFERGEKITHSEDKAASATVVHSS 640

  Fly   454 DIYNLYPLD----------------KNEEA------DVQQLEFNLNDSNP----PILNNYDNYEM 492
            :.....||.                |.::|      ||..|......|.|    |::...|. .|
plant   641 NSVEEEPLTASVQTVSMMPTQVMPVKLDQATNSTTVDVPVLSTRRTKSTPVRVMPVVLGRDT-SM 704

  Fly   493 AEDFP--------------VNQNLNYITNNYK----PVPATSTI---NASSKSIKKTTTTTLHKR 536
            |.|.|              :..:::.:|:..:    |.|....|   ....||.:.:.|:|...|
plant   705 ATDTPPVTSTRPDRTSATNLTSDVSGVTSKRQTRTSPAPVMPMILNQTTKMKSDEPSITSTWPDR 769

  Fly   537 T-----TNNMAGA-----KQTSTGIFGGSKLSQVSSVSSME------------------------ 567
            |     |::::|.     .:||.......||:|.:.:.|.|
plant   770 TSATDLTSDVSGVISSRQTRTSPAPVMPMKLNQKTKIKSDEPPITSTRPDRPSATNLTSDESPVT 834

  Fly   568 ----------------LH-------KLDDNMVLK----KSSSSNVV---------NKNKRPMGSA 596
                            |:       |.|:..|:.    ::||:.|:         ..::||:.|:
plant   835 STRQAKTSPAPVTPVILNQRQTTNMKSDEPPVISTRPLRTSSARVMPVILNQASTTYDERPLSSS 899

  Fly   597 QS----------------------------QFSKEN----------NQQKNIN------------ 611
            :|                            ..|..|          ||..|:.
plant   900 RSARTSPARIMPMKLNQADNMPSYEPPVALTRSARNSPARVIPVKLNQATNVTADASHIRSRQRF 964

  Fly   612 --VEIITKPPMRSRTTLDMRTSHQAKTQEKQ---IHQQQP-MNNRIIMDDHD-FDMLSRSHEAVL 669
              .:.:..|.:..:.| ||......|||:..   ..:::| ::.|  .||.| :::|.|:|..||
plant   965 SPTQTLATPAVFDQVT-DMTLDETTKTQQSSDILTQKEEPQISGR--EDDGDIWEILMRTHSEVL 1026

  Fly   670 QELSNRQSSLDLLRHATRSHDVLGALRQARSCG-KSIFIDLLGAILEKPSSWNLDFCMFVLPEIY 733
            ..|.:|.:.|.::||.....|:.||:...|... .|:..|::..:.:|.....||....:.|.:.
plant  1027 NTLQSRLTKLQIVRHFWERSDIKGAIAALRKLSDHSVQADVINILTDKTEILTLDLFSQLAPVLT 1091

  Fly   734 ELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQI- 797
            .||.|:.:.....:.:.|..:::.|...||..:.  |...:|||:..|:|.:.|..|...|.::
plant  1092 GLLGSKTERPVNVSLEMLLKLVAVFGTVIQSTVS--ARRVVGVDLHAEERLQICQSCSAELQKVQ 1154

  Fly   798 KNLPESTHFGSTL---SQLQNIII 818
            |.||..|..|..:   :|..|:::
plant  1155 KILPLLTRRGGLIARKAQELNLVL 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	36/137 (26%)
		WD40	<4..330	CDD:225201	109/338 (32%)
		WD40	14..260	CDD:238121	87/247 (35%)
		WD40 repeat	22..58	CDD:293791	18/36 (50%)
		WD40 repeat	63..99	CDD:293791	9/35 (26%)
		WD40 repeat	106..142	CDD:293791	12/35 (34%)
		WD40 repeat	148..184	CDD:293791	13/36 (36%)
		WD40 repeat	192..228	CDD:293791	16/35 (46%)
		WD40 repeat	285..310	CDD:293791	7/41 (17%)
DWA3	NP_176316.4	WD40	8..260	CDD:238121	90/256 (35%)
		WD40 repeat	19..56	CDD:293791	18/36 (50%)
		WD40 repeat	61..97	CDD:293791	9/35 (26%)
		WD40 repeat	104..139	CDD:293791	12/35 (34%)
		WD40 repeat	145..181	CDD:293791	12/35 (34%)
		WD40 repeat	187..222	CDD:293791	16/38 (42%)
		WD40 repeat	229..252	CDD:293791	7/22 (32%)
		Herpes_BLLF1	<670..>908	CDD:282904	42/238 (18%)
		Katanin_con80	1024..1175	CDD:404758	39/152 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	47	1.000	Domainoid score	I4526
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I915
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2740
orthoMCL	1	0.900	-	-		OOG6_103099
Panther	1	1.100	-	-	O	PTHR19845
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3736
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830