DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and AT1G11160

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_172582.2	Gene:	AT1G11160 / 837657	AraportID:	AT1G11160	Length:	1021	Species:	Arabidopsis thaliana

Alignment Length:	1054	Identity:	246/1054 - (23%)
Similarity:	404/1054 - (38%)	Gaps:	287/1054 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KIYDIKAHDSRVTSLDLG-ETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDN 73
            |:.:..||...|..|.:| :|.|:|:|||:|..||||:||:....|||.||...:|.|.|..::.
plant     7 KLQEFVAHSGNVNCLSIGKKTSRLLLTGGDDYKVNLWSIGKTTSPMSLCGHTSPVDSVAFNSEEV 71

  Fly    74 FVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCI 138
            .|.:....|:|:.|||...|:.....||..:...::|:|.||::.|||:||.:|:||.: :..||
plant    72 LVLAGASSGVIKLWDLEESKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDTNLRVWDTR-KKGCI 135

  Fly   139 KVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEF-IADPPVTAITCVQFHPFEF 202
            :..:||...:::::|||||.|:.|.||:..:.:||:...|.:.|| ..:.|:.::   .|||.||
plant   136 QTYKGHTRGISTIEFSPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKCHEGPIRSL---DFHPLEF 197

  Fly   203 LLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDRELD 267
            |||.|..|.||..:|||..:|:. ||......:|.|.|..:|:.||.|...|:.|..|||....|
plant   198 LLATGSADRTVKFWDLETFELIG-TTRPEATGVRAIAFHPDGQTLFCGLDDGLKVYSWEPVICRD 261

  Fly   268 HIKSTWSSLADMKVVNNKLICGCH----------------------------------------- 291
            .:...||:|.|..:...|.| ||.
plant   262 GVDMGWSTLGDFCINEGKFI-GCSYYRNSVGIWVSDISELEPYGAVSEDKNECMVKRFSVLNDQS 325

  Fly   292 -------------EIDTVSINTISLDRV---IPFYQPPNSL------------------------ 316
                         :.:|..|..|.:|..   :...|.|.||
plant   326 ERMGSGPRGSVSPDYETREIKNIYVDSTGGNLNVAQNPGSLKATLPLESGKVATMVSEKQNAAYF 390

  Fly   317 --PNFKHNSTNRKSFT--------RGNQKFRLSVGG--AKPAQVQ------EEHEGD-------- 355
              ...|::||:|.|.:        |.:..|..:..|  .:||.|:      ||.:..
plant   391 GPAGDKYSSTSRDSDSGEESSYSERESIPFSRTKSGMLLRPAHVRKTLAKFEESKQSAVVQSATR 455

  Fly   356 -KSGLS------SPNYSLEVVNEAVLESAETS-----------PMSSLPP-------------VH 389
             ||||:      :.|..|...|.:....||.|           .:||.||             :|
plant   456 KKSGLAVEEEPQTQNAFLSEQNASKPFDAEDSIIKGITNKFEKALSSEPPTDEANRMFLKPPRIH 520

  Fly   390 LASMA-------GSSADLAPHHVVYG-GAIDSALRQGKYSRVPDNMASYGSSYGAIDTRLMSLNE 446
            .:|.:       ..|||.|    .:| |.::::   |....:|..           ..|::|..:
plant   521 RSSNSKYNDTRRAMSADPA----TFGKGGMENS---GDVEDIPSK-----------TERVLSREK 567

  Fly   447 PSSLHKPDIY-----NLYPLDKNEEADV-------------------------QQLEFNLN---- 477
            |....|...|     .|.|:...|..:|                         ..:|.|.|
plant   568 PGDEQKNTEYPSGSRELNPVKIVEGVNVVSGRTRSLVEKFERGEKTTHTEGASTTIEQNNNAVQE 632

  Fly   478 --------------------DSNP----PILNNYDNYEMAEDFPVNQNLNYITNNYKPVPA---- 514
                                .|.|    ||:.|.|:...:::.|:.|...  |:::..:|.
plant   633 DPRKTSRQTGETPVISTRRARSTPARVMPIVLNRDSNVTSDEPPLTQPAR--TSSFPVMPVILNQ 695

  Fly   515 TSTINASSKSIKKT-TTTTLHKR---TTNNMAGAKQTSTGIFGGSKLSQVSSVSSMELHKLDDN- 574
            .|.:.....|:..| .:.|.|.|   .|.|.|      |.|        .|..:|:.|.:...|
plant   696 ASNVTYDEPSVALTQESRTSHARILPVTFNQA------TNI--------TSEEASVTLRRQRRNS 746

  Fly   575 ------MVLKKSSSSNVVNKNKRPMGSAQSQ-FSKENNQQKNIN--------------VEIITKP 618
                  ::|.:::|......:.||:.::.:: ...:.||..|:.              .:::..|
plant   747 AARVRPVLLSQATSHECPVTSVRPLRTSPARVMPTKLNQSVNMTSDTSHIASMHRVSPTQMLATP 811

  Fly   619 PMRSRT---TLDMRTSHQAKTQEKQIHQQQPMNNRIIMDDHDF-DMLSRSHEAVLQELSNRQSSL 679
            .:..:.   |||...:.|.:.....:.|::..|.....||.|. :.|..:|...|..|.:|.:.|
plant   812 TVIDQVADMTLDETHATQIQPACDNMPQKEEPNISDREDDSDITENLMLTHNEFLSTLQSRLTKL 876

  Fly   680 DLLRHATRSHDVLGALRQARS-CGKSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFH 743
            .::||.....||.||:...|. ..:|:..|::..:.||.....||....::|.:..||.|:.:..
plant   877 QIVRHFWERSDVKGAIGALRKLTDQSVQADVISILTEKIEILTLDMFSQLVPVLTSLLGSRTERP 941

  Fly   744 FTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKN-LPESTHFG 807
            ...:.|.|..:::.|...|:..:.  |...:|||:...:|...|..|...|.:|:. ||.....|
plant   942 VNVSLDMLLKLVAVFGTVIRSTVS--APRIVGVDLHANERLEICQICSAGLHKIQRILPVLARRG 1004

  Fly   808 STL---SQLQNIII 818
            ..:   :|..|:::
plant  1005 GLITRKAQELNLVL 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	36/137 (26%)
		WD40	<4..330	CDD:225201	119/404 (29%)
		WD40	14..260	CDD:238121	93/247 (38%)
		WD40 repeat	22..58	CDD:293791	18/36 (50%)
		WD40 repeat	63..99	CDD:293791	10/35 (29%)
		WD40 repeat	106..142	CDD:293791	14/35 (40%)
		WD40 repeat	148..184	CDD:293791	14/36 (39%)
		WD40 repeat	192..228	CDD:293791	16/35 (46%)
		WD40 repeat	285..310	CDD:293791	8/81 (10%)
AT1G11160	NP_172582.2	WD40	3..253	CDD:238121	94/250 (38%)
		WD40	<7..310	CDD:225201	106/308 (34%)
		WD40 repeat	19..56	CDD:293791	18/36 (50%)
		WD40 repeat	61..97	CDD:293791	10/35 (29%)
		WD40 repeat	104..139	CDD:293791	14/35 (40%)
		WD40 repeat	145..181	CDD:293791	13/35 (37%)
		WD40 repeat	187..222	CDD:293791	16/38 (42%)
		WD40 repeat	229..254	CDD:293791	9/24 (38%)
		Katanin_con80	864..1015	CDD:290636	38/152 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I3090
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I915
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2740
orthoMCL	1	0.900	-	-		OOG6_103099
Panther	1	1.100	-	-	O	PTHR19845
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830