DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and AT5G23430

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_851064.1	Gene:	AT5G23430 / 832409	AraportID:	AT5G23430	Length:	837	Species:	Arabidopsis thaliana

Alignment Length:	909	Identity:	232/909 - (25%)
Similarity:	366/909 - (40%)	Gaps:	199/909 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KIYDIKAHDSRVTSLDLG-ETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDN 73
            |:.:..||.:.|..|.:| ::.|||||||||..|||||||:....:||.||:..||.|.|...:.
plant     8 KLQEFVAHSAAVNCLKIGRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEV 72

  Fly    74 FVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCI 138
            .|.:....|.|:.|||...||..||.||..:..::||:|.||:..|||.||.:::||:: :..||
plant    73 LVAAGAASGTIKLWDLEEAKIVRTLTGHRSNCISVDFHPFGEFFASGSLDTNLKIWDIR-KKGCI 136

  Fly   139 KVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFHPFEFL 203
            ...:||...||.::|:|||.|:.|.|.:..:.:||:...|.:.||.:..  ..|..:.|||.|||
plant   137 HTYKGHTRGVNVLRFTPDGRWVVSGGEDNIVKVWDLTAGKLLTEFKSHE--GQIQSLDFHPHEFL 199

  Fly   204 LAAGRVDGTVSIYDLEHQQLVS----QTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDR 264
            ||.|..|.||..:|||..:|:.    :|.     .:||::|:.:|:.:..|....:.:..|||.|
plant   200 LATGSADRTVKFWDLETFELIGSGGPETA-----GVRCLSFNPDGKTVLCGLQESLKIFSWEPIR 259

  Fly   265 ELDHIKSTWSSLADMKVVNNKLICGC-HEIDTVSINTISLDRVIPFY------------------ 310
            ..|.:...||.|:||.|...||: || :....|.:..:.|.|..|..
plant   260 CHDGVDVGWSRLSDMNVHEGKLL-GCSYNQSCVGVWVVDLSRTEPCMAGDTAQSNGHPEKRSCSG 323

  Fly   311 QPP--------------------------------------NSLPNFKHNSTNRKSFTRGNQKF- 336
            :.|                                      ||.|:.|...:..:|.|..|.:.
plant   324 RDPVVLNDNNSKTVLGKLSVSQNVDPLLKETKSLGRLSVSQNSDPSTKETKSIGRSSTSQNSESS 388

  Fly   337 --------RLSVGGAKPAQVQEEHE---------GDKSGLSSPNYSLEV--VNEAVLESAETSPM 382
                    ||||  ::.:.|.:|..         |....:||.|.|...  |:.|| .:|.||..
plant   389 MKESKPLGRLSV--SQNSDVSKESRTFSSTGSLPGTPHRVSSTNVSKATSGVSTAV-SNAATSRR 450

  Fly   383 SSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSYG--AIDTRLMSLN 445
            :.......|:....:||.||  |:...| |..:.|...||...::.:....|.  |.|:|    .
plant   451 NFTKANPKANPVNKAADFAP--VIVPRA-DPRIEQATESRAELDIIARTMPYSLQAADSR----R 508

  Fly   446 EPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFPVNQNLNYITNNYK 510
            .|||.:.||:         .:|.|                    .||:|..||..|
plant   509 SPSSRNNPDL---------PDASV--------------------LEMSESQPVEPN--------- 535

  Fly   511 PVPATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSKLSQVSSVSSM----ELHKL 571
            .:|...|:.....                .|.||.:.|...|...:..:.:|.|.|    ..|..
plant   536 NIPDGGTLPGGKV----------------GMRGATERSINDFRYKRYGRSNSRSRMGSPPRNHDE 584

  Fly   572 DDNMVLKKSS--------------SSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMRS 622
            :.::|..:|:              .|.|:|:.:|      .:||.......|.:...:..|.:|.
plant   585 NYDLVSHRSNRDPSPTESQKGGRFQSLVINRERR------GRFSNFEGPVSNFSSGNMPAPNIRP 643

  Fly   623 RTTLDMRTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQSSLDLLRHATR 687
            ......|.:|....|    ....|....|:.|      :...|...:..:.:|.:.|.::|....
plant   644 SNMFKQRGNHMPVEQ----GIDSPSEENIVED------IMGKHNQFVSSMQSRLAKLQVVRRYWE 698

  Fly   688 SHDV---LGALRQARSCGKSIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFHFTRACD 749
            .:||   :|::.  :....::..|:||.|.|:.....||.|..:||.:..||.|....|.:.:.|
plant   699 RNDVKNSIGSIE--KMADNAVTADVLGIITERNEILTLDNCTSLLPLLTALLGSGMDQHLSVSLD 761

  Fly   750 TLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKN-LPESTHFGSTLSQ 812
            .|..::..:...|..:|.:.|:  :|||:..|.|..:.:.|...|.::|. ||.....|..:::
plant   762 LLLKLVRLYGSPIYSSLSAPAS--VGVDIEAEQRIERYSRCFVELEKVKACLPSLARRGGLVAK 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	35/139 (25%)
		WD40	<4..330	CDD:225201	120/381 (31%)
		WD40	14..260	CDD:238121	94/250 (38%)
		WD40 repeat	22..58	CDD:293791	20/36 (56%)
		WD40 repeat	63..99	CDD:293791	13/35 (37%)
		WD40 repeat	106..142	CDD:293791	14/35 (40%)
		WD40 repeat	148..184	CDD:293791	13/35 (37%)
		WD40 repeat	192..228	CDD:293791	17/39 (44%)
		WD40 repeat	285..310	CDD:293791	8/25 (32%)
AT5G23430	NP_851064.1	WD40	9..261	CDD:238121	98/259 (38%)
		WD40 repeat	63..99	CDD:293791	13/35 (37%)
		WD40 repeat	104..140	CDD:293791	14/36 (39%)
		WD40 repeat	147..182	CDD:293791	12/34 (35%)
		WD40 repeat	188..222	CDD:293791	17/33 (52%)
		Katanin_con80	678..829	CDD:372820	36/150 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I3090
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4302
Inparanoid	1	1.050	271	1.000	Inparanoid score	I915
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425951at2759
OrthoFinder	1	1.000	-	-		FOG0006599
OrthoInspector	1	1.000	-	-		otm2740
orthoMCL	1	0.900	-	-		OOG6_103099
Panther	1	1.100	-	-	LDO	PTHR19845
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830