DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and AT5G08390

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_568194.2	Gene:	AT5G08390 / 830737	AraportID:	AT5G08390	Length:	839	Species:	Arabidopsis thaliana

Alignment Length:	878	Identity:	232/878 - (26%)
Similarity:	387/878 - (44%)	Gaps:	129/878 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KIYDIKAHDSRVTSLDLG-ETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDN 73
            |:.:..||.:.|..|.:| ::.|||||||||..|||||||:....:||.||:..||.|.|...:.
plant     8 KLQEFVAHSAAVNCLKIGRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEG 72

  Fly    74 FVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCI 138
            .|.:....|.|:.|||...|:..||.||..:..:::|:|.||:..|||.||.:::||:: :..||
plant    73 LVAAGAASGTIKLWDLEEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIR-KKGCI 136

  Fly   139 KVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFHPFEFL 203
            ...:||...||.::|:|||.||.|.|.:..:.:||:...|.:.||.:..  ..|..:.|||.|||
plant   137 HTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKSHE--GKIQSLDFHPHEFL 199

  Fly   204 LAAGRVDGTVSIYDLEHQQLV----SQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDR 264
            ||.|..|.||..:|||..:|:    ::||     .:||:||:.:|:.:..|....:.:..|||.|
plant   200 LATGSADKTVKFWDLETFELIGSGGTETT-----GVRCLTFNPDGKSVLCGLQESLKIFSWEPIR 259

  Fly   265 ELDHIKSTWSSLADMKVVNNKLICGC-HEIDTVSINTISLDRVIPF---YQPPNSLPNFKHNSTN 325
            ..|.:...||:|:||.|...||: || :..:.|.:..:.|.|..|.   ....||.|. |.:.:.
plant   260 CHDGVDVGWSNLSDMNVHEGKLL-GCSYNQNCVGVWVVDLSRTEPMSGGATQSNSHPE-KTSGSG 322

  Fly   326 RKSFTRGNQKFRLSVGGAKPAQ-----VQEEHEGDKSGLSS-----PNYSLEVVNEAVLESA--- 377
            |......:...::.:|....:|     ::|.....|..:|.     |..:......:|.:|:
plant   323 RDQAGLNDNSSKVILGKLPGSQKVDPLLKETKSLGKLSVSQNSDPLPKDTKSTGRSSVSQSSDPL 387

  Fly   378 --ETSPMSSLPPVHLA---------SMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYG 431
              |..|:......|.:         |..||.:| :||.|....|..||   ...|.|..|.|:..
plant   388 VKEPKPLGRFSATHSSDTVKESRTLSSTGSVSD-SPHRVTLTSAPKSA---SGISTVVPNAAASK 448

  Fly   432 SSYGAIDTRLMSLNEPSSLHKPDIYNLY-----PLDKNEEADVQQLEFNLNDSNPPILNNYDNYE 491
            .::|..:.:.    .|..::|.|.:.:.     |:  .|:|...:.|.::.....|    |....
plant   449 RNFGKANPKA----NPPVVNKEDYFPVIVPRTEPI--IEQASESRAELDIIGRTMP----YSLQS 503

  Fly   492 MAEDFPVNQNLNYITNNYKPVPATSTINAS-SKSIKKTTTTTLHKRTT--NNMAGA--------K 545
            .|.|   ::.|: .:.|...:|.:|.:..| |:.|:   ..||....|  ::..|:        |
plant   504 KAAD---SRRLS-SSRNEPDLPTSSLLERSQSQPIE---PITLQDGNTYPSDEGGSWDTAERTNK 561

  Fly   546 QTSTGIFGGSKLSQVSSVSSMELHKLDDNMVL-----KKSSS-----------SNVVNKNKRPMG 594
            ::...:||  :.:..|.|.|...:. |:|..|     .:.||           |.|:|:.:|
plant   562 ESKCRVFG--RFNSRSLVRSPPRNH-DENSDLISYNANRDSSPTESRKGGRLHSLVLNRERR--- 620

  Fly   595 SAQSQFSKENNQQKNINVEIITKPPMRSRTTLDMRTSHQAKTQEKQIHQQQPMNNRIIM---DDH 656
               .:||.......:.:...:|.|..|....|..|.:|            .|::..|..   :|.
plant   621 ---GRFSNFEGPVSSSSGGNMTAPNSRPSNMLKQRGNH------------VPVDQGITSASEEDI 670

  Fly   657 DFDMLSRSHEAVLQELSNRQSSLDLLRHATRSHDVLGALRQ-ARSCGKSIFIDLLGAILEKPSSW 720
            ..|::.: |:..:..:.:|.:.|.::|.....:|:..::.. .:....::..|:|..:.|:|...
plant   671 VADIMGQ-HDQFVSSMHSRLAKLQVVRRYWERNDIKNSISSIEKMADNAVIADVLLIVNERPEIL 734

  Fly   721 NLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQR 785
            .||.|..:||.:..||.|....|.:...|.|..::..:...|..:|.  |.:.:|||:..|.|..
plant   735 TLDTCTSLLPLLTALLGSNMDSHLSVCLDLLLKLVRMYGSQIYSSLS--APSSVGVDIEAEQRME 797

  Fly   786 KCAECQRWLLQIKN-LPESTHFGS----TLSQL 813
            :.:.|.....:||. ||.....|:    ||.:|
plant   798 RYSCCFVEFEKIKACLPSLARRGNLVAKTLHEL 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	32/137 (23%)
		WD40	<4..330	CDD:225201	120/328 (37%)
		WD40	14..260	CDD:238121	95/250 (38%)
		WD40 repeat	22..58	CDD:293791	20/36 (56%)
		WD40 repeat	63..99	CDD:293791	12/35 (34%)
		WD40 repeat	106..142	CDD:293791	13/35 (37%)
		WD40 repeat	148..184	CDD:293791	14/35 (40%)
		WD40 repeat	192..228	CDD:293791	17/39 (44%)
		WD40 repeat	285..310	CDD:293791	8/28 (29%)
AT5G08390	NP_568194.2	WD40	9..261	CDD:238121	99/259 (38%)
		WD40 repeat	63..99	CDD:293791	12/35 (34%)
		WD40 repeat	104..140	CDD:293791	13/36 (36%)
		WD40 repeat	147..182	CDD:293791	13/34 (38%)
		WD40 repeat	188..222	CDD:293791	17/33 (52%)
		Katanin_con80	680..831	CDD:404758	36/153 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I3090
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4302
Inparanoid	1	1.050	271	1.000	Inparanoid score	I915
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425951at2759
OrthoFinder	1	1.000	-	-		FOG0006599
OrthoInspector	1	1.000	-	-		otm2740
orthoMCL	1	0.900	-	-		OOG6_103099
Panther	1	1.100	-	-	O	PTHR19845
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830