DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kat80 and Ercc8

DIOPT Version :9

Sequence 1:NP_523363.2 Gene:kat80 / 32581 FlyBaseID:FBgn0040207 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_082318.2 Gene:Ercc8 / 71991 MGIID:1919241 Length:397 Species:Mus musculus


Alignment Length:352 Identity:65/352 - (18%)
Similarity:132/352 - (37%) Gaps:117/352 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 ISKIYDI-KAHDSRVTSLDLGET-GRVLVTGGEDRNVNLW-----------------AIGQNECF 53
            ::|..|: :.|.|.|.:||:... ||.:::||.|..|.|:                 ::|::...
Mouse    32 LNKDRDVERIHGSGVNTLDIEPVEGRYMLSGGSDGVVVLYDLENASRQPHYTCKAVCSVGRSHPD 96

  Fly    54 MSLTGHNRSIDCVRFAYKDNFVYSADDIG-IIRRWDLNS----------QKIYS----------- 96
            :    |..|::.|::...|..::::.... .::.||.|:          :.:||           
Mouse    97 V----HKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHC 157

  Fly    97 -----------------------TLNGHMKSVRTLDFNPSGEYVV-SGSNDTTVRLWDVQNENNC 137
                                   .|.||.:.:..:.::|..:|:: :.|.|:.|:||||:..:.|
Mouse   158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGC 222

  Fly   138 I---------------KVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIW--------------- 172
            :               .....|...||.:.|:.|||.:.:.|.:..:.:|               
Mouse   223 LLTLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGDNTLVNYGKV 287

  Fly   173 --DIRKSKQIMEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAI 235
              |.||..|.          |::|.....|.|:...    .|:::|.:...:.::.....| :::
Mouse   288 CNDSRKGLQF----------AVSCGCSSEFVFVPHG----STIAVYAVHSGERLAMLKGHY-KSV 337

  Fly   236 RCITFSDNGECLFVGSSSGISVIGWEP 262
            .|..|..|.:.|:.||.. .:::.|.|
Mouse   338 DCCVFQPNFQELYSGSRD-CNILAWVP 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kat80NP_523363.2 Katanin_con80 667..803 CDD:290636
WD40 <4..330 CDD:225201 65/352 (18%)
WD40 14..260 CDD:238121 61/342 (18%)
WD40 repeat 22..58 CDD:293791 10/53 (19%)
WD40 repeat 63..99 CDD:293791 7/80 (9%)
WD40 repeat 106..142 CDD:293791 10/51 (20%)
WD40 repeat 148..184 CDD:293791 12/52 (23%)
WD40 repeat 192..228 CDD:293791 5/35 (14%)
WD40 repeat 285..310 CDD:293791
Ercc8NP_082318.2 WD40 40..>369 CDD:225201 63/344 (18%)
WD40 40..361 CDD:295369 61/340 (18%)
WD 1 41..81 12/39 (31%)
WD40 repeat 47..97 CDD:293791 10/49 (20%)
WD 2 97..137 7/43 (16%)
WD40 repeat 102..141 CDD:293791 5/38 (13%)
WD40 repeat 145..183 CDD:293791 2/37 (5%)
WD 3 184..224 12/39 (31%)
WD40 repeat 189..227 CDD:293791 10/37 (27%)
WD 4 243..282 9/38 (24%)
WD40 repeat 248..274 CDD:293791 8/25 (32%)
WD40 repeat 295..331 CDD:293791 7/49 (14%)
WD 5 332..371 9/34 (26%)
WD40 repeat 337..361 CDD:293791 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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