DRSC/TRiP Functional Genomics Resources

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Protein Alignment kat80 and apaf1

DIOPT Version :9

Sequence 1:NP_523363.2 Gene:kat80 / 32581 FlyBaseID:FBgn0040207 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_571683.1 Gene:apaf1 / 58131 ZFINID:ZDB-GENE-000616-4 Length:1261 Species:Danio rerio


Alignment Length:378 Identity:80/378 - (21%)
Similarity:148/378 - (39%) Gaps:81/378 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQ---------------NECFMSLTGH 59
            |:.:::||:..|.........|.:.|...||.|.||.:.:               |.|..:.||.
Zfish   651 KLLELQAHEEDVLCCAFSPDDRHIATCASDRKVKLWNVERGVLIREFEVEHEEQINHCQFTNTGR 715

  Fly    60 NRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDT 124
            .     |..|...|     |.....|.|:.|.:...:|:.|||:.|....|:|:..|:.:.|:|.
Zfish   716 R-----VLLATCSN-----DKFTNTRLWNPNKKTSQNTMFGHMEPVNHCCFSPNDLYLATSSSDG 770

  Fly   125 TVRLWDVQ--NENNCIKVCRGHMSHVNSVK-------FSPDGLWIASAGLEGSILIWDIRKSKQI 180
            :::|::|.  ||...|.|..........:|       :|.||..|..|. ..::.::|:..|..:
Zfish   771 SLKLFEVSSANEWKSIDVDSFFPESDEEIKAMVKCSTWSADGSQIICAA-RNTVFVFDVETSDLL 834

  Fly   181 MEFIADPPVTAITCVQF-H--PFEFLLAAGRVDGTVSIYDLEHQQLVSQTT-HFYGQAIRCITFS 241
            ::.    ..:.::.:|| |  |...|||......||.:::.|..:..::.: |.  ..:.|:.||
Zfish   835 LKL----KTSRLSTIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHL--SWVHCVQFS 893

  Fly   242 DNGECLFVGSSSGISVIGWEPD-----------RELDHIK---------------------STWS 274
            .:|. |.:.||...::..||.|           |:.|.:.                     ||.:
Zfish   894 PDGS-LLLSSSDDQTIRLWETDRVHTSSAVALKRDTDVLSSHSDATIIAPDSSNRLQVLSGSTGA 957

  Fly   275 SLADMKVVNNKLICGCHEIDTVSINTISLDRVIPFYQPPNSLPNFK---HNST 324
            .:.:.:.:::::.|.|...:...:...|.|..:...:.|:|..:.|   |..|
Zfish   958 VVLESEELSSRIRCSCISRNAAFVALGSEDGTVQVIEVPSSKASVKLSGHTKT 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kat80NP_523363.2 Katanin_con80 667..803 CDD:290636
WD40 <4..330 CDD:225201 80/378 (21%)
WD40 14..260 CDD:238121 63/273 (23%)
WD40 repeat 22..58 CDD:293791 9/50 (18%)
WD40 repeat 63..99 CDD:293791 8/35 (23%)
WD40 repeat 106..142 CDD:293791 11/37 (30%)
WD40 repeat 148..184 CDD:293791 8/42 (19%)
WD40 repeat 192..228 CDD:293791 10/38 (26%)
WD40 repeat 285..310 CDD:293791 4/24 (17%)
apaf1NP_571683.1 DD 7..92 CDD:301326
NB-ARC 132..411 CDD:279299
P-loop_NTPase 150..297 CDD:304359
WD 1 615..654 1/2 (50%)
WD40 616..912 CDD:238121 64/278 (23%)
WD40 repeat 625..657 CDD:293791 1/5 (20%)
WD40 641..1042 CDD:225201 80/378 (21%)
WD 2 657..696 10/38 (26%)
WD40 repeat 663..699 CDD:293791 7/35 (20%)
WD 3 700..743 11/52 (21%)
WD40 repeat 705..745 CDD:293791 12/49 (24%)
WD 4 746..785 13/38 (34%)
WD40 repeat 752..796 CDD:293791 11/43 (26%)
WD 5 798..836 8/38 (21%)
WD40 repeat 803..841 CDD:293791 7/42 (17%)
WD 6 840..879 10/38 (26%)
WD40 851..1256 CDD:225201 31/163 (19%)
WD40 877..1212 CDD:238121 24/137 (18%)
WD 7 882..921 11/41 (27%)
WD40 repeat 887..911 CDD:293791 7/24 (29%)
WD40 repeat 960..1005 CDD:293791 7/44 (16%)
WD 8 964..1003 6/38 (16%)
WD 9 1006..1045 2/5 (40%)
WD40 repeat 1011..1046 CDD:293791 80/378 (21%)
WD 10 1047..1088
WD 11 1091..1130
WD40 repeat 1096..1132 CDD:293791
WD 12 1133..1172
WD40 repeat 1138..1162 CDD:293791
WD 13 1184..1223
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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