DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and tle2b

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_021329162.1	Gene:	tle2b / 564019	ZFINID:	ZDB-GENE-050208-677	Length:	763	Species:	Danio rerio

Alignment Length:	353	Identity:	73/353 - (20%)
Similarity:	133/353 - (37%)	Gaps:	85/353 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYS--- 77
            :|...|.::.:..:.|.:.|||:. .|.:|.|.|......:.    .:||:.   :||::.|
Zfish   475 SHGEVVCAVTISTSTRHVYTGGKG-CVKVWDISQPGSKSPMA----QLDCLN---RDNYIRSCKI 531

  Fly    78 ---------ADDIGIIRRWDL--NSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDV 131
                     ..:...:..|||  .:.:|.:.|.....:...|..:|..:...|..:|..:.:||:
Zfish   532 LPDGRTLIVGGEASTLSIWDLATPTPRIKAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDL 596

  Fly   132 QNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQ 196
            .|: ..::..:||....:.:..|.||..:.:.||:.::..||:|:.:|:               |
Zfish   597 HNQ-TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWDLREGRQL---------------Q 645

  Fly   197 FHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVG-SSSGISVIG- 259
            .|.|           |..|:.|.:                |.|    ||.|.|| .||.:.|:.
Zfish   646 QHDF-----------TSQIFSLGY----------------CPT----GEWLAVGMESSNVEVLHV 679

  Fly   260 WEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIPFYQPPNSLPNF--KHN 322
            .:||:...|:..  |.:..:|..    .||...:.|      ..|.::..::.|.....|  |..
Zfish   680 SKPDKYQLHLHE--SCVLSLKFA----YCGKWFVST------GKDNLLNAWRTPYGASIFQSKET 732

  Fly   323 STNRKSFTRGNQKFRLSVGGAKPAQVQE 350
            |:........:.|:.::..|.|.|.|.|
Zfish   733 SSVLSCDVSPDDKYIVTGSGDKKATVYE 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	67/331 (20%)
		WD40	14..260	CDD:238121	54/259 (21%)
		WD40 repeat	22..58	CDD:293791	8/35 (23%)
		WD40 repeat	63..99	CDD:293791	9/49 (18%)
		WD40 repeat	106..142	CDD:293791	7/35 (20%)
		WD40 repeat	148..184	CDD:293791	9/35 (26%)
		WD40 repeat	192..228	CDD:293791	6/35 (17%)
		WD40 repeat	285..310	CDD:293791	4/24 (17%)
tle2b	XP_021329162.1	TLE_N	1..128	CDD:309152
		WD40	471..760	CDD:238121	72/351 (21%)
		WD40 repeat	480..519	CDD:293791	9/43 (21%)
		WD40 repeat	527..565	CDD:293791	6/37 (16%)
		WD40 repeat	570..606	CDD:293791	7/36 (19%)
		WD40 repeat	613..648	CDD:293791	10/49 (20%)
		WD40 repeat	653..686	CDD:293791	14/52 (27%)
		WD40 repeat	694..728	CDD:293791	6/43 (14%)
		WD40 repeat	735..759	CDD:293791	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910