DRSC/TRiP Functional Genomics Resources

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Protein Alignment kat80 and ATG16L1

DIOPT Version :9

Sequence 1:NP_523363.2 Gene:kat80 / 32581 FlyBaseID:FBgn0040207 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_001350671.1 Gene:ATG16L1 / 55054 HGNCID:21498 Length:624 Species:Homo sapiens


Alignment Length:295 Identity:78/295 - (26%)
Similarity:124/295 - (42%) Gaps:51/295 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 IYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFM--SLTGHNRSIDCVRFAYKDN 73
            ::|  |||..|.::......|:|.|||.||.|.||.:...:|..  ||:|.|..|..:.|....:
Human   334 VFD--AHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGS 396

  Fly    74 FVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCI 138
            ::.:|.:....|.|.::..::..||.||...|.:..|......:||||:|.|::|||:::: .||
Human   397 YLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSK-VCI 460

  Fly   139 K-VCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQI--MEFIADPPVTAITCVQFHPF 200
            | |..|  |..|.:..:..  .:.|...:..|..||||....:  ||.:.     .||.:..:|.
Human   461 KTVFAG--SSCNDIVCTEQ--CVMSGHFDKKIRFWDIRSESIVREMELLG-----KITALDLNPE 516

  Fly   201 EFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRC------ITFSDNGECLFVGS-------- 251
            ...|.:...|..:.:.|| ....:.||  |.....:|      :.||.:|..:..||        
Human   517 RTELLSCSRDDLLKVIDL-RTNAIKQT--FSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIW 578

  Fly   252 ---------------SSGISVIGWEPDRELDHIKS 271
                           ||.|:.:.|.|..  .|:.|
Human   579 SVLTGKVEKVLSKQHSSSINAVAWSPSG--SHVVS 611

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kat80NP_523363.2 Katanin_con80 667..803 CDD:290636
WD40 <4..330 CDD:225201 78/295 (26%)
WD40 14..260 CDD:238121 73/279 (26%)
WD40 repeat 22..58 CDD:293791 13/37 (35%)
WD40 repeat 63..99 CDD:293791 6/35 (17%)
WD40 repeat 106..142 CDD:293791 14/36 (39%)
WD40 repeat 148..184 CDD:293791 9/37 (24%)
WD40 repeat 192..228 CDD:293791 8/35 (23%)
WD40 repeat 285..310 CDD:293791
ATG16L1NP_001350671.1 ATG16 31..206 CDD:312208
WD40 <272..390 CDD:225201 21/57 (37%)
WD40 332..622 CDD:238121 78/295 (26%)
WD40 repeat 344..381 CDD:293791 13/36 (36%)
WD40 repeat 387..423 CDD:293791 6/35 (17%)
WD40 repeat 428..465 CDD:293791 15/37 (41%)
WD40 repeat 473..503 CDD:293791 6/31 (19%)
WD40 repeat 508..544 CDD:293791 9/38 (24%)
WD40 repeat 554..590 CDD:293791 5/35 (14%)
WD40 repeat 597..621 CDD:293791 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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