DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and katnb1

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_998183.1	Gene:	katnb1 / 406291	ZFINID:	ZDB-GENE-040426-1954	Length:	694	Species:	Danio rerio

Alignment Length:	849	Identity:	238/849 - (28%)
Similarity:	365/849 - (42%)	Gaps:	198/849 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALPRKLIS--KIYDIKAHDSRVTSLDLGE-TGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRS 62
            |||....|:  |:.:|.||.|.|:||.||: :||:|.|||||..||:||:.:..|.||||||..:
Zfish     1 MALTNTTITSWKLQEIVAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSA 65

  Fly    63 IDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVR 127
            :.|::|...:..|.:....|.:|.|||.:.||..||.||..|:.:|||:|.|||:.|||.|:.::
Zfish    66 VGCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIK 130

  Fly   128 LWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAI 192
            ||||:.: .|:...:||...|..:.|||||.|:|||..:.::.:||:...|.|.||.:.  .:|:
Zfish   131 LWDVRRK-GCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSH--TSAV 192

  Fly   193 TCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISV 257
            ..|||||.|:|||:|..|.||.::|||...::..:....| .:|.:.|:.:|.||:.||.:.:.|
Zfish   193 NVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETG-VVRSVLFNPDGSCLYSGSENTLRV 256

  Fly   258 IGWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIP--------FYQPPN 314
            .||||||..|.:...|..::|:.:.||::|...:....||...:.|:||..        ....|.
Zfish   257 YGWEPDRCFDVVHVGWGKVSDLAISNNQMIAVSYSHTNVSWYVVDLNRVKKSGSVIQGLIQDKPI 321

  Fly   315 SLPNFKHNSTNRKSFTR------------GNQKFRLSVGGAKPAQVQEEHEGDKSG---LSSPNY 364
            ..|:....:|.|:::.|            .::..|.|..|.:.:...|:.:.||..   :::|..
Zfish   322 PAPSSALGTTLRRNYERPTTSCTGQEMKQSSEADRRSPEGERRSPSSEDEKEDKESSAEITNPED 386

  Fly   365 SLEVVNEAVLESAETSPMSSLP-PVHLASMAGSSADLAPHHVV--YGGAIDSALRQGKYSRVPDN 426
            ..|:.....:.| .|.|.::.| |..|......|....|..||  ....||.|
Zfish   387 YKEIFQPRSVIS-RTPPKTTEPFPAPLEHSFSESVLEKPGPVVKIVTPVIDRA------------ 438

  Fly   427 MASYGSSYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYE 491
                |...|.|                          .....||::|..:..:.|
Zfish   439 ----GQLKGPI--------------------------TSSTPVQRVEPTVIAAAP---------- 463

  Fly   492 MAEDFPVNQNLNYITNNYKPVPATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSK 556
                              :|| |..|.:|||.| :....||..|.:|..:...:....|:..|..
Zfish   464 ------------------RPV-AVVTTSASSPS-RPVVNTTKPKPSTGIILSTRNEPIGLNAGDF 508

  Fly   557 LSQVSSVSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMR 621
            ||...:.               |:|:          ||
Zfish   509 LSHARNA---------------KASA----------MG--------------------------- 521

  Fly   622 SRTTLDMRTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQSSLDLLRHAT 686
                                            |:.....:.:.|:.:...||:|..:||.:|...
Zfish   522 --------------------------------DEEALAQIRKGHDTMCVMLSSRSKNLDSVRSVW 554

  Fly   687 RSHDVLGALRQARSCGK-SIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFHFTRACDT 750
            .|.||..:|..|.|... ||.:|:|..|..|||.|.||.|..:||:|.|||||:::.:....|.:
Zfish   555 ASGDVKTSLDSAVSMNDLSIVVDVLNIINLKPSLWKLDLCTSILPQIEELLQSRYESYVQTGCMS 619

  Fly   751 LRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPEST-----HFGSTL 810
            |::||..|.|.|.:.|:  |...:|||:|||:|.:||..|.:.|..:.|:.::.     ..|||.
Zfish   620 LKLILKRFWPLISDTLN--APPSVGVDITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTF 682

  Fly   811 SQLQ 814
            .:||
Zfish   683 RELQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	53/136 (39%)
		WD40	<4..330	CDD:225201	126/336 (38%)
		WD40	14..260	CDD:238121	103/246 (42%)
		WD40 repeat	22..58	CDD:293791	20/36 (56%)
		WD40 repeat	63..99	CDD:293791	11/35 (31%)
		WD40 repeat	106..142	CDD:293791	16/35 (46%)
		WD40 repeat	148..184	CDD:293791	15/35 (43%)
		WD40 repeat	192..228	CDD:293791	16/35 (46%)
		WD40 repeat	285..310	CDD:293791	6/32 (19%)
katnb1	NP_998183.1	WD40	<3..295	CDD:225201	118/295 (40%)
		WD40	13..292	CDD:238121	115/282 (41%)
		WD 1	18..58		21/39 (54%)
		WD 2	61..100		12/38 (32%)
		WD40 repeat	67..103	CDD:293791	12/35 (34%)
		WD 3	103..142		19/39 (49%)
		WD40 repeat	108..144	CDD:293791	16/36 (44%)
		WD 4	145..186		17/40 (43%)
		WD40 repeat	151..186	CDD:293791	14/34 (41%)
		WD 5	188..226		17/39 (44%)
		WD40 repeat	192..228	CDD:293791	16/35 (46%)
		WD 6	229..269		16/40 (40%)
		WD40 repeat	234..268	CDD:293791	15/33 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..410		17/91 (19%)
		Rib_recp_KP_reg	346..476	CDD:282899	34/201 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		9/22 (41%)
		Katanin_con80	535..686	CDD:290636	56/152 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575023
Domainoid	1	1.000	97	1.000	Domainoid score	I7245
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4302
Inparanoid	1	1.050	345	1.000	Inparanoid score	I2296
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159977at33208
OrthoFinder	1	1.000	-	-		FOG0006599
OrthoInspector	1	1.000	-	-		oto39641
orthoMCL	1	0.900	-	-		OOG6_103099
Panther	1	1.100	-	-	LDO	PTHR19845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5030
SonicParanoid	1	1.000	-	-		X3736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830