DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and wsb1

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_989387.1	Gene:	wsb1 / 395021	XenbaseID:	XB-GENE-5920309	Length:	422	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	78/333 - (23%)
Similarity:	132/333 - (39%)	Gaps:	60/333 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SRVTSLDLGETGRVLVTGGEDRNVN----LWAIG--------QNECFMSLTGHNRSIDCVRFAYK 71
            ||..| |||:..:.:     :..::    :|::.        |:.|.        :|:..||.:.
Frog    87 SRQNS-DLGQRNKPI-----EHTIDCGDIVWSLAFGSSVPEKQSRCV--------NIEWHRFKFG 137

  Fly    72 DNFVYSADDI--GIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYV-VSGSNDTTVRLWDVQN 133
            .:.:..|..:  |.|:.||:.:.|:...|..|.:.||.|.|.|.|..: ||.|.|.|:|:||:::
Frog   138 QDQLLLATGLSNGRIKIWDVYTGKLLLNLMDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202

  Fly   134 ENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFH 198
            :.|.:||.|||.:.|....||||...:.|.|...::.:||:.|...|.:.  |.....:...:|.
Frog   203 DGNMMKVLRGHQNWVYCCAFSPDSSMLCSVGAGKAVFLWDMDKYTMIRKL--DGHYNDVVACEFS 265

  Fly   199 PFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPD 263
            |...|||....|..|.::|.....::.:..|.:..........|||.              |...
Frog   266 PDGALLATASYDTRVYVWDPHIGSILFEFGHLFPPPTPIFAGGDNGR--------------WVKS 316

  Fly   264 RELDHIKSTWSSLADMKVVN---------------NKLICGCHEIDTVSINTISLDRVIPFYQPP 313
            ....|.....:||||..:|.               :|.:|.....|...:...:.|....|:..|
Frog   317 VSFSHDGVHIASLADDNLVRFWRIDKSYPVEVAPLSKGLCCAFSTDGSVLAAGTQDGNAYFWSTP 381

  Fly   314 NSLPNFKH 321
            ..:.:.:|
Frog   382 KYVSSLQH 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	78/333 (23%)
		WD40	14..260	CDD:238121	64/255 (25%)
		WD40 repeat	22..58	CDD:293791	7/47 (15%)
		WD40 repeat	63..99	CDD:293791	9/37 (24%)
		WD40 repeat	106..142	CDD:293791	16/36 (44%)
		WD40 repeat	148..184	CDD:293791	11/35 (31%)
		WD40 repeat	192..228	CDD:293791	8/35 (23%)
		WD40 repeat	285..310	CDD:293791	4/24 (17%)
wsb1	NP_989387.1	WD 1	124..165		10/48 (21%)
		WD40 repeat	134..168	CDD:293791	8/33 (24%)
		WD40	135..379	CDD:238121	64/259 (25%)
		WD 2	168..208		16/39 (41%)
		WD40 repeat	174..212	CDD:293791	16/37 (43%)
		WD 3	212..251		13/38 (34%)
		WD40 repeat	217..253	CDD:293791	11/37 (30%)
		WD 4	254..293		8/38 (21%)
		WD40 repeat	261..307	CDD:293791	9/45 (20%)
		WD 5	309..346		10/50 (20%)
		WD40 repeat	314..353	CDD:293791	6/38 (16%)
		WD40 repeat	354..390	CDD:293791	6/36 (17%)
		SOCS_WSB1_SWIP1	382..421	CDD:239715	1/8 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910