DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and Brwd3

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001074946.1	Gene:	Brwd3 / 382236	MGIID:	3029414	Length:	1799	Species:	Mus musculus

Alignment Length:	905	Identity:	170/905 - (18%)
Similarity:	311/905 - (34%)	Gaps:	275/905 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSG 120
            :.||..|:.||.|......:::..|..:::.|..:..::.:||.||...:..:..|.....:.:|
Mouse   176 ILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAG 240

  Fly   121 SNDTTVRLWDVQNENNCIKVC------RGHMSHVNSVKFSPD----GLWIASAGLEGSILIWDIR 175
            |.|..||:|       |::.|      :||.:.:.|::|.|.    ..::.|.|.:|:|..|  :
Mouse   241 SCDKVVRVW-------CLRTCAPVAVLQGHSASITSIQFCPSTKGTTRYLTSTGADGTICFW--Q 296

  Fly   176 KSKQIMEFIADP--------PVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQ------QLVSQ 226
            ...:.|:|...|        |...|:|..|......:..|..|..:.||.|..:      :|.|.
Mouse   297 WHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEIPEKIAELESH 361

  Fly   227 TTHFYGQAIRCITFSDNGECL-FV-GSSSGISVIGWEPDRELDHIKSTWSSLA-DM--KVVNNKL 286
            |     ..:..:.|.:||:.| || ||..|.:.| |:      :.:..|.|:. ||  |:..|.|
Mouse   362 T-----DKVVAVQFCNNGDSLRFVSGSRDGTARI-WQ------YQQQEWKSIVLDMATKMSGNNL 414

  Fly   287 ICGCHEIDTVSINTISLDR----VIPFYQPPNSLPNFKHNSTNRKSFTRG--------------N 333
            .....::..:.:..::.||    ||....  |.|....::.|.:...|..              :
Mouse   415 TSAEDKVTKLKVTMVAWDRYDTTVITAVN--NFLLKVWNSVTGQLLHTLSGHDDEVFVLEAHPFD 477

  Fly   334 QKFRLSVGGAKPAQVQEEHEGD------KSGLSSPNY--SLEVVNEAVLESAETSPMSSLPPVHL 390
            |:..||.|          |:|:      ..|....||  .:|......:...:.||..:    |.
Mouse   478 QRIILSAG----------HDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGN----HF 528

  Fly   391 ASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSYGAI--DTRLMSLNE------- 446
            |     ..|...|.:::|.....     .|.::||.| .:.:.|..:  |.....|:|
Mouse   529 A-----CTDSHGHLLLFGFGCSK-----YYEKIPDQM-FFHTDYRPLIRDANNYVLDEQTQQAPH 582

  Fly   447 ---PSSL-------HKPDIYNLYPLDKN--EEADVQQLEF---------------NLNDSNPPIL 484
               |..|       |......|.|..:|  :|..:.||.:               ..||....||
Mouse   583 LMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQEESIL 647

  Fly   485 NNYDNYEMAEDFPVNQNLNYITNN---YKPVPATSTINA--SSKSIKKTTTTTLHKRTTNNMAGA 544
            :.     :..:....|:|..|...   :.|:..:.::|.  ||.::...::..:..|.:..:.|.
Mouse   648 DG-----IIRELQREQDLRLINEGDVPHFPINRSYSVNGALSSPNMDIPSSPNIGLRRSGQIEGV 707

  Fly   545 KQTSTGIFGGSKLSQVSSVSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKE-NNQQK 608
            :|    :...:..||:::...           |...|...|||:    :.|..|:..:| .|.:.
Mouse   708 RQ----MHNNAPRSQMATERD-----------LMAWSRRVVVNE----LNSGVSRVQEECRNAKG 753

  Fly   609 NINVEIITKPPMRSRTTLDMRTSHQ-------AKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHE 666
            ::.|.:.|....:..:....|..:|       .:||.|:.|.....:|    .:|:..  :.|..
Mouse   754 DLEVSLYTVEKKKKPSYPIQRNDYQPSCGRSLRRTQRKRQHTYLTRSN----IEHNSQ--ASSQT 812

  Fly   667 AVLQELSNRQSSLDLLRHATRSHDVLGALRQARSCGKSIFIDLLGAILEKP-------------- 717
            :.:||.|:..|..|                  .:.|.|      .|.:|.|
Mouse   813 SGVQEDSDSSSEED------------------ETVGTS------DASVEDPVVEWQSESSSSDSS 853

  Fly   718 ---SSWNLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVT 779
               |.|..|..:.:.|...:..|:..|.:.:...:.|::
Mouse   854 SEYSDWIADAGINLQPPKRQTRQATQKIYSSSEDENLKL-------------------------- 892

  Fly   780 REDRQRKCAECQR--------------------WLLQIKNLPESTHFGSTLSQLQNIIIF 819
             ||||:|..:.::                    |:|.  .:|..:.|   :.|:.:.:|:
Mouse   893 -EDRQKKPKQTKKKKGGLVSMAGEPNEEWLAPQWILD--TIPRRSPF---VPQMGDELIY 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	25/172 (15%)
		WD40	<4..330	CDD:225201	71/306 (23%)
		WD40	14..260	CDD:238121	56/229 (24%)
		WD40 repeat	22..58	CDD:293791	0/1 (0%)
		WD40 repeat	63..99	CDD:293791	6/35 (17%)
		WD40 repeat	106..142	CDD:293791	9/41 (22%)
		WD40 repeat	148..184	CDD:293791	9/39 (23%)
		WD40 repeat	192..228	CDD:293791	10/41 (24%)
		WD40 repeat	285..310	CDD:293791	5/28 (18%)
Brwd3	NP_001074946.1	WD 1	170..209		8/32 (25%)
		WD40	172..494	CDD:238121	78/350 (22%)
		WD40	175..540	CDD:225201	88/405 (22%)
		WD40 repeat	183..220	CDD:293791	7/36 (19%)
		WD 2	213..251		11/44 (25%)
		WD40 repeat	226..262	CDD:293791	9/42 (21%)
		WD 3	255..297		10/43 (23%)
		WD40 repeat	267..313	CDD:293791	11/47 (23%)
		WD 4	307..347		9/39 (23%)
		WD40 repeat	321..359	CDD:293791	8/37 (22%)
		WD 5	353..393		14/51 (27%)
		WD40 repeat	365..410	CDD:293791	16/51 (31%)
		WD 6	400..452		12/53 (23%)
		WD40 repeat	426..462	CDD:293791	8/37 (22%)
		WD 7	456..495		7/48 (15%)
		WD40 repeat	468..493	CDD:293791	6/34 (18%)
		WD 8	502..542		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..912		31/202 (15%)
		Bromo_WDR9_I_like	1128..1240	CDD:99958
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1258..1291
		Bromodomain	1299..1439	CDD:295360
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1367
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1435..1482
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1517..1723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910