DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and Wdr24

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001178013.1	Gene:	Wdr24 / 360497	RGDID:	1304803	Length:	790	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	142/741 - (19%)
Similarity:	239/741 - (32%)	Gaps:	286/741 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ISKIYDIKAHDSRVTSLDLGETGR-------------------VLVTGGEDRNVNLWAIG----- 48
            |.|||.|: .:..|..|:| ..||                   :|.|...:..|..|.:|
  Rat    48 IFKIYAIE-EEQFVEKLNL-RVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRN 110

  Fly    49 -QNECFMSLTGHNRSIDCVRF-AYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFN 111
             |::.|   |.|.|:::.|.| ..:.:.:.|....|.::.:||..:...||.:|..:|||.:.|:
  Rat   111 KQDQLF---TEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFS 172

  Fly   112 PSGEYVVSGS-NDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSP-DGLWIASAGLEGSILIWDI 174
            ....:..:.: .:..|:|||::..:.|.::...|...|....:.| |..|:|:.|.:..:.:||:
  Rat   173 IRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDM 237

  Fly   175 --RKSKQI--MEFIADPPVTAITCVQFHP---FEFLLAAGRVDGTVSIYDL-----------EHQ 221
              .::|:|  ::.||     ::..|::.|   ......:..||..:.::|:           ||:
  Rat   238 TTHRAKEIHCVQTIA-----SVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHR 297

  Fly   222 QLVSQTT---------------------HFYGQAIR----------C--------------ITFS 241
            .:.:...                     |.:..|.:          |              :..:
  Rat   298 DVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAVKESLVAA 362

  Fly   242 DNGECLFVG---------------------SSSGISV---------IGWEPD------------- 263
            ::|...:.|                     :||.:||         :.|..|
  Rat   363 ESGRKPYAGDRRHPIFFKRKLDPAEPFSGLASSALSVFETESGGGSMSWFVDTAERYALAGRPLA 427

  Fly   264 ----------REL--DHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIPFYQPPN-- 314
                      |||  :.:..||:.|                            |:|  |..|.
  Rat   428 ELCDHNAKVARELGRNQVAQTWTML----------------------------RII--YCSPGLV 462

  Fly   315 SLPNFKH-------------NSTNRKSFTRG-NQKFRL--SVGGAKPAQV-------------QE 350
            |..|..|             ||.|.|....| ..:.||  |.|..:...|             .|
  Rat   463 SSANLNHSVGKGSSCSLPLMNSFNLKDMGPGLGSETRLDRSKGDTRSDTVLLDSSATLITNEDNE 527

  Fly   351 EHE----------GDKSGLSSPNYSLEVVNEAVLESAETSPMSSLP-----------PVHLASMA 394
            |.|          ||..|.....|.|:..:....|.....|..:.|           |.||...|
  Rat   528 ETEGSDVPADYLLGDVEGEEDELYPLDTEHVHPEEPEYVLPQEAFPLRHEIVDTPSGPEHLQDKA 592

  Fly   395 GSSADLAPHHVVYGGAIDSALRQGKYSRVP-DNMASYGS-SYGAIDTRLMSLNEPSSLHKPDIYN 457
            .|     ||  |.|...|:|      |..| |:.:|..| |:...|:||          .||.::
  Rat   593 DS-----PH--VSGNEADTA------SLAPVDSSSSLLSVSHALYDSRL----------PPDFFS 634

  Fly   458 LYPLDK----NEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFPVNQNLNYITNNYKPVPATSTI 518
            :...|.    .|:.|||.....|......:..:.|  |..::       ::.|:....:......
  Rat   635 VLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDID--EQTQE-------HWYTSYIDLLQRFCLW 690

  Fly   519 NASSKSIKKTT----------TTTLH 534
            |.|::.:|.:|          :||||
  Rat   691 NVSNEVVKLSTSRAVSCLNQASTTLH 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	86/482 (18%)
		WD40	14..260	CDD:238121	63/366 (17%)
		WD40 repeat	22..58	CDD:293791	11/60 (18%)
		WD40 repeat	63..99	CDD:293791	8/36 (22%)
		WD40 repeat	106..142	CDD:293791	7/36 (19%)
		WD40 repeat	148..184	CDD:293791	10/40 (25%)
		WD40 repeat	192..228	CDD:293791	7/49 (14%)
		WD40 repeat	285..310	CDD:293791	2/24 (8%)
Wdr24	NP_001178013.1	WD40 repeat	75..118	CDD:293791	7/45 (16%)
		WD40	<86..323	CDD:421866	48/244 (20%)
		WD40 repeat	124..161	CDD:293791	8/36 (22%)
		WD40 repeat	166..203	CDD:293791	8/36 (22%)
		WD40 repeat	211..247	CDD:293791	9/35 (26%)
		WD40 repeat	254..294	CDD:293791	5/39 (13%)
		mRING-H2-C3H3C2_WDR24	742..787	CDD:319607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910