DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and Wdr59

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001164214.1	Gene:	Wdr59 / 319481	MGIID:	2442115	Length:	993	Species:	Mus musculus

Alignment Length:	694	Identity:	139/694 - (20%)
Similarity:	258/694 - (37%)	Gaps:	178/694 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IKAHDSRVTSLDLGETGRVLVTGGEDRN----VNLWAIGQNECFMSLTGHNR-------SIDCVR 67
            ::..||:.|::.:...|:..|..|  |.    |||.|        ...||.:       .|..|:
Mouse    12 VEFRDSQATAMSVDCLGQHAVLSG--RRFLYIVNLDA--------PFEGHRKISRQSKWDIGAVQ 66

  Fly    68 FAYKDNFVY----SADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLD---FNPSGEYVVSGSNDTT 125
            :...|:|.:    |::....:.:|...|.::.:||.||.:.:..||   |.|  :.:|:.|.||.
Mouse    67 WNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEP--DLLVTSSVDTY 129

  Fly   126 VRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVT 190
            :.:||:::... ..|....::..:.||::.......:...:|.:.|||.||....:|::| ..::
Mouse   130 IYIWDIKDTRK-PTVALSAVAGASQVKWNKKNANYLATSHDGDVRIWDKRKPSTAVEYLA-AHLS 192

  Fly   191 AITCVQFHP-FEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRC---------ITFSD--- 242
            .|..:.:|| .|.:.|....|.:|..:|....:.       |...:.|         ..||:
Mouse   193 KIHGLDWHPDSEHIFATSSQDNSVKFWDYRQPRK-------YLNILPCQVPVWKARYTPFSNGLV 250

  Fly   243 ----------------NGECL------FVGSSSGISVIGWEPDRE--LDHIKSTWSSLADMKV-- 281
                            |...|      |||....:....|...:|  .|:...|||....:::
Mouse   251 TVMVPQLRRENSLLLWNASDLNAPVHTFVGHDDVVLEFQWRRQKEGSKDYQLVTWSRDQTLRMWR 315

  Fly   282 VNNKL--ICGCHEIDTVS--INTISLDRVIPFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGG 342
            |:.::  :|....:|.|.  |.:|||   :|   .|...|: ..:..::.|.:.|.:.   ::..
Mouse   316 VDYQMQRLCANDILDGVDEFIESISL---LP---EPEKTPH-PQDIDHQPSLSHGEED---AIKE 370

  Fly   343 AKPAQVQEEHEGDKSGL--------SSPNYSLEVVNEAVLESAETSPMSSLPPVHLASMAGSSAD 399
            ..|:.:.||...|:.||        |..|..:..|| ..:::|:.|...|   ||.::.......
Mouse   371 DPPSSLLEEKRSDQLGLPQTLQQEFSLINVQIRNVN-VEMDAADRSCTVS---VHCSNHRVKMLV 431

  Fly   400 LAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSY---------GAIDTRLMSLNEPSSLHK--- 452
            ..|                  ::.|:|.|   .|:         .|:..:|:.:.:.:||.|
Mouse   432 TFP------------------AQYPNNAA---PSFQFINPTTITSAVKAKLLKILKDTSLQKVKR 475

  Fly   453 ------PDIYNLYP-LDK--NEEADVQQLEFNLNDS-NPP------ILNNYDNYEMAEDFPVNQN 501
                  |.:..|.. |:.  |:|.......|.|.:| .||      :...|.:|:.|       |
Mouse   476 NQSCLEPCLRQLVSCLESFVNQEDSASSNPFALQNSVTPPLPTFARVTTAYGSYQDA-------N 533

  Fly   502 LNYITNNYKPVPATSTIN--ASSKSIKKTTTTTLHKR------TTNNMAGAKQTSTGIFGGSKLS 558
            :        |.|.||...  .:...:..|...|:|:.      |..:::......||:....|:
Mouse   534 I--------PFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKI- 589

  Fly   559 QVSSVSSMELHKLDDNMVLKKS-SSSNVVNKNKRPMGSAQSQFS 601
            :..:..::.|:........|:. |.|:...|.:....||:.::|
Mouse   590 RTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMSPRSARRRWS 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	80/376 (21%)
		WD40	14..260	CDD:238121	62/298 (21%)
		WD40 repeat	22..58	CDD:293791	9/39 (23%)
		WD40 repeat	63..99	CDD:293791	8/39 (21%)
		WD40 repeat	106..142	CDD:293791	11/38 (29%)
		WD40 repeat	148..184	CDD:293791	9/35 (26%)
		WD40 repeat	192..228	CDD:293791	8/36 (22%)
		WD40 repeat	285..310	CDD:293791	8/28 (29%)
Wdr59	NP_001164214.1	WD40	<34..314	CDD:225201	63/300 (21%)
		WD40 repeat	62..103	CDD:293791	9/40 (23%)
		WD40	100..>343	CDD:295369	56/256 (22%)
		WD40 repeat	109..150	CDD:293791	11/43 (26%)
		WD40 repeat	154..188	CDD:293791	9/33 (27%)
		WD40 repeat	195..229	CDD:293791	8/40 (20%)
		WD40 repeat	237..279	CDD:293791	4/41 (10%)
		WD40 repeat	285..316	CDD:293791	6/30 (20%)
		RWD	394..494	CDD:214735	22/124 (18%)
		Zn_ribbon_17	943..991	CDD:305234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910