DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and Phip

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_038938466.1	Gene:	Phip / 315843	RGDID:	1564964	Length:	1822	Species:	Rattus norvegicus

Alignment Length:	692	Identity:	135/692 - (19%)
Similarity:	233/692 - (33%)	Gaps:	215/692 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSG 120
            :.||..|:.||.|......:::..|..:::.|..:..::.:||.||...:..:..|.....:.:|
  Rat   179 ILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAG 243

  Fly   121 SNDTTVRLWDVQNENNCIKVC------RGHMSHVNSVKFSP----DGLWIASAGLEGSILIW--- 172
            |.|..:|:|       |::.|      :||.:.:.|::|||    ...:::|.|.:|:|..|
  Rat   244 SCDKMIRVW-------CLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD 301

  Fly   173 --DIRKSKQIMEFIADP-PVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQ--LVSQTTHFYG 232
              .::.:.:..:|...| |...:.|..|......||.|..|..:.:|.....|  .:|: ..|:.
  Rat   302 AGTLKINPRPTKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISE-LEFHT 365

  Fly   233 QAIRCITFSDNGECLFVGSSSGISVIGWEPDRELDHIKSTWSS-LADMKV---------VNNKLI 287
            ..:..|.||:.......||..|.:.| |:..|.      .|.| |.||..         :.:|
  Rat   366 DKVDSIQFSNTSNRFVSGSRDGTARI-WQFKRR------EWKSILLDMATRPAGQNLQGIEDK-- 421

  Fly   288 CGCHEIDTVSINTISLDRVIPFYQPPNSLPNFKHNST-----NR------KSFTRGNQKFRLSVG 341
                 |..:.:..::.||               |:||     |.      .|:|  .|...:..|
  Rat   422 -----ITKMKVTMVAWDR---------------HDSTVITAVNNMTLKVWNSYT--GQLIHVLTG 464

  Fly   342 GAKPAQVQEEHEGDKSGLSSPNYSLEVV---------------------NEAVLESAETSPMSSL 385
            ......|.|.|..|...|.|..:...|:                     :.||.: .:.||...
  Rat   465 HEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKVRSYFNMIEGQGHGAVFD-CKCSPDGQ- 527

  Fly   386 PPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSYGAI--DTRLMSLNEPS 448
               |.|     ..|...|.|::|....|     ||.::.|.| .:.|.|..:  |.....|:|.:
  Rat   528 ---HFA-----CTDSHGHLVIFGFGSSS-----KYDKIADQM-FFHSDYRPLIRDANNFVLDEQT 578

  Fly   449 SLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFPVNQNLNYITNNYKPVP 513
            . ..|   :|.|                    ||.|.:.|.                    .|.|
  Rat   579 Q-QAP---HLMP--------------------PPFLVDVDG--------------------NPHP 599

  Fly   514 ATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQ---------TSTG---IFGGSKLSQVSSVSSM 566
            :.                  ::|........::         ||:|   :.....:..:|.:.||
  Rat   600 SR------------------YQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQAIQDISPLDSM 646

  Fly   567 ELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMRSRTTLDMRTS 631
             :.:|.....|::|..:.|.:..:...||..|             ...:..||     .:.:|.|
  Rat   647 -IQRLQQEQDLRRSGEAAVSSAGRLNRGSVSS-------------TSEVHSPP-----NVGLRRS 692

  Fly   632 HQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELS 673
            .|.: ..:|:|...|.:.  |..:.  |:::.|...|:.|||
  Rat   693 GQIE-GVRQMHSNAPRSE--IATER--DLVAWSRRVVVPELS 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	4/7 (57%)
		WD40	<4..330	CDD:225201	67/312 (21%)
		WD40	14..260	CDD:238121	51/221 (23%)
		WD40 repeat	22..58	CDD:293791	0/1 (0%)
		WD40 repeat	63..99	CDD:293791	6/35 (17%)
		WD40 repeat	106..142	CDD:293791	8/41 (20%)
		WD40 repeat	148..184	CDD:293791	9/44 (20%)
		WD40 repeat	192..228	CDD:293791	9/37 (24%)
		WD40 repeat	285..310	CDD:293791	4/24 (17%)
Phip	XP_038938466.1	WD40	175..495	CDD:238121	77/354 (22%)
		WD40 repeat	186..223	CDD:293791	7/36 (19%)
		WD40 repeat	229..265	CDD:293791	8/42 (19%)
		WD40 repeat	270..315	CDD:293791	9/44 (20%)
		WD40 repeat	323..362	CDD:293791	9/39 (23%)
		WD40 repeat	368..416	CDD:293791	14/54 (26%)
		WD40 repeat	424..463	CDD:293791	9/55 (16%)
		WD40 repeat	469..494	CDD:293791	7/24 (29%)
		Bromo_WDR9_I_like	1148..1263	CDD:99958
		Bromo_WDR9_II	1316..1434	CDD:99928
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910