DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and MAPKBP1

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001122080.1	Gene:	MAPKBP1 / 23005	HGNCID:	29536	Length:	1514	Species:	Homo sapiens

Alignment Length:	749	Identity:	145/749 - (19%)
Similarity:	260/749 - (34%)	Gaps:	226/749 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ISKIYDIKAHDSRVTSLDLG--ETG-RVLVTGGEDRNVNLWAIGQNECF-MSLTGHNRSIDCVRF 68
            :|::..::||||.:..|:..  :|| ::|.:...||.:::...|:.... .:|..|:.||..|:|
Human   511 LSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKF 575

  Fly    69 AYKDNFV----YSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTL---DFNPSGEYVVSGSNDTTV 126
            |..|..|    ..||.....|....:...:..|...|:....||   |..||.:|...|..|..:
Human   576 AASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNI 640

  Fly   127 RLWDVQN--ENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPV 189
            |::::.:  :....|..:|....:..|:..|.|::||:
Human   641 RIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIAT--------------------------- 678

  Fly   190 TAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSG 254
               :|              .|..:||:|....:.|: |...:.:.:..:.||:  :|..:.|.||
Human   679 ---SC--------------SDKNLSIFDFSSGECVA-TMFGHSEIVTGMKFSN--DCKHLISVSG 723

  Fly   255 ISVIGWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISL-DRVIPFYQPPNSLPN 318
            .|.|            ..|...::|                    |||: .|:....|.......
Human   724 DSCI------------FVWRLSSEM--------------------TISMRQRLAELRQRQRGGKQ 756

  Fly   319 FKHNSTNRKSFTRGNQ-KFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVNEAVLESAETSPM 382
            ...:|..|.|....:| ...||.|.|..:  ..:.||:..|......:|.|:.::..::..:.|.
Human   757 QGPSSPQRASGPNRHQAPSMLSPGPALSS--DSDKEGEDEGTEEELPALPVLAKSTKKALASVPS 819

  Fly   383 SSLPPVHLASMAGSSADLAPHHVVYGGAIDSA-------LRQGKYSRVPDNMASYGS--SYGAID 438
            .:||    .|::......|...|   |.:|.|       .|:|::.: |....|..|  ....::
Human   820 PALP----RSLSHWEMSRAQESV---GFLDPAPAANPGPRRRGRWVQ-PGVELSVRSMLDLRQLE 876

  Fly   439 TRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSN--------------PPILNNYDN 489
            |...||.:||.    |...:.|....:... :.||.:|...|              |.|:.....
Human   877 TLAPSLQDPSQ----DSLAIIPSGPRKHGQ-EALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQ 936

  Fly   490 YE--MAEDF---PVNQNLNYITNNYKPVPATS-TINASSKSIKKTTTTTLHKRTTNNMAGAKQTS 548
            .|  .|:|.   |:...:.|      |.|:.: |::.|...::               |.|:.|.
Human   937 EEGVFAQDLEPAPIEDGIVY------PEPSDNPTMDTSEFQVQ---------------APARGTL 980

  Fly   549 TGIFGGSKLSQ-------------VSSVSSMELHKLDDNMVLKKSSSSNVVNKNKRPM------- 593
            ..::.||:.|:             .|.:||.| |..:|:...:..|...:.:..:.|.
Human   981 GRVYPGSRSSEKHSPDSACSVDYSSSCLSSPE-HPTEDSESTEPLSVDGISSDLEEPAEGDEEEE 1044

  Fly   594 -------------GSAQS----QFSK-------------------ENNQQKNIN----VEIITKP 618
                         ||.|:    ||.|                   |.::.::|:    :::.|:|
Human  1045 EEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLLQVQTRP 1109

  Fly   619 ---PMRSRTTLDMRTSHQAKTQEKQIHQQQPMNN 649
               |..|.::|.:.:   ...|..|...:||..|
Human  1110 LREPSPSSSSLALMS---RPAQVPQASGEQPRGN 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	67/335 (20%)
		WD40	14..260	CDD:238121	56/258 (22%)
		WD40 repeat	22..58	CDD:293791	8/39 (21%)
		WD40 repeat	63..99	CDD:293791	10/39 (26%)
		WD40 repeat	106..142	CDD:293791	10/40 (25%)
		WD40 repeat	148..184	CDD:293791	5/35 (14%)
		WD40 repeat	192..228	CDD:293791	6/35 (17%)
		WD40 repeat	285..310	CDD:293791	4/25 (16%)
MAPKBP1	NP_001122080.1	WD40	83..427	CDD:295369
		WD 1	88..129
		WD40 repeat	93..132	CDD:293791
		WD 2	132..173
		WD40 repeat	138..172	CDD:293791
		WD 3	175..213
		WD40 repeat	180..218	CDD:293791
		WD40	228..725	CDD:225201	55/260 (21%)
		WD 4	276..315
		WD40 repeat	280..317	CDD:293791
		WD40 repeat	335..384	CDD:293791
		WD 5	342..381
		WD40	349..731	CDD:295369	57/278 (21%)
		WD 6	387..436
		WD 7	477..516		1/4 (25%)
		WD40 repeat	484..519	CDD:293791	1/7 (14%)
		WD 8	519..561		11/41 (27%)
		WD40 repeat	525..565	CDD:293791	8/39 (21%)
		WD 9	565..606		11/40 (28%)
		WD40 repeat	570..610	CDD:293791	10/39 (26%)
		WD 10	614..653		9/38 (24%)
		WD40 repeat	620..655	CDD:293791	7/34 (21%)
		WD 11	659..698		12/83 (14%)
		WD40 repeat	662..700	CDD:293791	12/82 (15%)
		WD 12	701..740		12/72 (17%)
		WD40 repeat	706..732	CDD:293791	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..804		12/57 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..925		10/49 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..1256		37/215 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910