DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and npp-23

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_501537.2	Gene:	npp-23 / 182462	WormBaseID:	WBGene00007493	Length:	371	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	77/368 - (20%)
Similarity:	144/368 - (39%)	Gaps:	96/368 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DIKAHDSRVTSLDLGETGRVLVTGGEDRN--VNLWAIGQN-ECFMSLTGHNRSID---------- 64
            |:|.  |::  |..|||...:::.|:.|.  ::||..... :.|..|...|..||
Worm    36 DVKL--SKI--LFTGETSSQIISLGKGRGRCISLWERDDGIDPFKVLATKNSEIDPNDACTMTDN 96

  Fly    65 --CVRFAYKDNFVYSA--DDIGIIRRW-DLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDT 124
              |:.:|.....|:|.  ||:.::.|. .::|......:..|            |..::|.|::.
Worm    97 RVCIGYADGSLAVFSTDKDDLALMSRIPSIHSGSASRKICRH------------GNSILSASSNG 149

  Fly   125 TVRLWDVQ---------NENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQI 180
            ::...||:         .:.....||....::|           :.:....|.|.:||:|::.:.
Worm   150 SLVAVDVETGMPRTIFTGQAGIRSVCTTFGTNV-----------VMAGDANGQITMWDLRENNEH 203

  Fly   181 MEFIADPPVT---------AITCVQFHPFEF-LLAAGRVDGTVSIYDLEHQQLVSQTTHFY--GQ 233
            ...: ||..|         |:|.:..||.:. |:..|..||.|.:.|..:.:..:.|:.:.  .:
Worm   204 SNTL-DPIKTLIPSKKALDAVTALCSHPAQSNLVCCGTDDGIVGLIDARNVRGANITSTYLVAKK 267

  Fly   234 AIRCITF-----------SDNGECLFVGSSSGISVIGWEPDRELDHIKSTWSSLADMKVVNNKLI 287
            ||..:.|           |::|..:.:.:|.....:|....::...::....:...:..:.|:.:
Worm   268 AISQVMFHPKCGDNLLVSSNDGSLIRIDASGAPIAVGPRSTKDTIWLEGDLVNSLRLDPIRNESV 332

  Fly   288 CGCHEI-------DTV----SINTISLDRVIPFYQPPNSLPNF 319
               |.|       |||    ||..|||.:.:||:  |||  ||
Worm   333 ---HSISSFDIRSDTVVTASSIGLISLYQQLPFF--PNS--NF 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	77/368 (21%)
		WD40	14..260	CDD:238121	57/295 (19%)
		WD40 repeat	22..58	CDD:293791	10/38 (26%)
		WD40 repeat	63..99	CDD:293791	10/50 (20%)
		WD40 repeat	106..142	CDD:293791	6/44 (14%)
		WD40 repeat	148..184	CDD:293791	6/35 (17%)
		WD40 repeat	192..228	CDD:293791	9/36 (25%)
		WD40 repeat	285..310	CDD:293791	11/35 (31%)
npp-23	NP_501537.2	WD40	20..357	CDD:225201	69/351 (20%)
		WD40	96..>329	CDD:295369	43/256 (17%)
		WD40 repeat	133..166	CDD:293791	6/44 (14%)
		WD40 repeat	171..208	CDD:293791	8/48 (17%)
		WD40 repeat	223..264	CDD:293791	10/40 (25%)
		WD40 repeat	269..294	CDD:293791	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910