DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and F47G4.4

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_493453.1	Gene:	F47G4.4 / 173271	WormBaseID:	WBGene00009825	Length:	722	Species:	Caenorhabditis elegans

Alignment Length:	794	Identity:	166/794 - (20%)
Similarity:	292/794 - (36%)	Gaps:	220/794 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 IDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTL---DFNPSGEYVVSGSNDT 124
            |:|:|.:..:..:.:|.: .|::..|:.:......|.||...:.:|   .|||...|  :||:|.
Worm    55 IECLRLSTDERTIGAATN-AILKVADIITGHEVRNLTGHTLPITSLAASKFNPYCWY--TGSSDC 116

  Fly   125 TVRLWDVQNENNCIKVCRGHM-SHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPP 188
            ....||.:  .|..|:..... ..|.|:..||...::| .|.:.:|.|:|.|:.:.|..|
Worm   117 DWTQWDTR--MNPSKIFGSKTPGVVRSIALSPGDRYVA-VGTDETIQIFDARQREFIKTF----- 173

  Fly   189 VTAITC----VQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFV 249
                .|    ::.||.:.||::...|..|..:.||..:::||:..|... |:...|..:  .:..
Worm   174 ----NCSGHALELHPSDVLLSSVGHDRIVRFFCLETFEMISQSDPFLDD-IQASAFDTH--VMIA 231

  Fly   250 GSSSGISVIGWEPDRELDHIKSTWSSLADM-KVVN---NKL----ICGCHEIDTVSINTISLDRV 306
            .::..|:::.|||..::    .|...|.:: ||||   |.|    ||.....:.:.:.|.:::.:
Worm   232 ATNDSINLLTWEPCCDI----LTTVPLKNVEKVVNVNANGLDLDFICIGDNTERLEMRTYAIEEL 292

  Fly   307 IPFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEGDKSGLS----------- 360
            :. |.|.:.|..                           :..:|:.:.|.|.:.
Worm   293 LS-YSPSHELCG---------------------------SIYEEDEDVDNSPIDEVKALPELTEL 329

  Fly   361 ------SPNYSLE-------VVNEAVLESAETSPMSSLPPVHLASMAGSSADLAPHHVVYGGAID 412
                  ||..|.|       .||.:...|:.|||:...|..|     .|::...|
Worm   330 SNLPPRSPGLSCEETETSASPVNSSSSHSSPTSPVKPAPVKH-----RSASQKLP---------- 379

  Fly   413 SALRQGKYSRVPDNMASYGSSYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLN 477
                 ||.::.. |....||      ||.::   |.|...|..:....              ::.
Worm   380 -----GKSTKTL-NPKPAGS------TRSVT---PVSTKPPRTFGTAK--------------SVI 415

  Fly   478 DSNPPILNNYDNYEMAEDFPVNQNLNYITNNYKPVPATSTINASSKSIKKTTTTTL-----HKRT 537
            .|:.|.|:.|:                  |...|.|:.|.:. ::||:..:||:.|     .||:
Worm   416 VSSKPSLSGYN------------------NRANPSPSMSDLR-TTKSMAGSTTSLLSERAPKKRS 461

  Fly   538 TNNMAGAKQTSTGIFG-------GSKLSQVSSVSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGS 595
            |::....:..:....|       |...|.|||.:|.  ::.....|.||:|..::......|...
Worm   462 TSSRRNQEPITITYIGRPRTPSEGDVASTVSSSTSR--NRRPSPSVAKKTSPPSIYAITSSPAKR 524

  Fly   596 AQSQFSKENNQQKNINVEIITKPPMRSRTTLDMRTSHQAKTQEKQIHQQQPMN--NRIIMDDHDF 658
            |.|..|....:::|              :|..:.::..|||         |:.  ...|...||.
Worm   525 ASSTASGPTARRQN--------------STSSVTSTTSAKT---------PVGVWGACIETVHDI 566

  Fly   659 DMLSRSHEAVLQEL----SNRQSSLDLLRHATRSHD-VLGALRQARSCGKSIFIDLLGAILEKPS 718
            .::::.....::.|    |.|.|::|:......... ||.|.|                ||.:.:
Worm   567 GIVAKKENRNIRRLKMLTSRRTSNVDIPPEVCSDEQLVLTATR----------------ILSRRN 615

  Fly   719 SWNLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWA---ANGLGVDVTR 780
            .|:|:.|...||.|.:.:.|....:...|.:.|..|..    |:.|.|..:|   ::.:||||..
Worm   616 DWSLNSCHAYLPVIIDNIASVDVTNRAIALEGLAAIAD----TLGERLVKFASMNSHRIGVDVAA 676

  Fly   781 EDRQRKCAECQRWL 794
            |:|..|...|.:.|
Worm   677 EERAEKAKACVQHL 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	34/136 (25%)
		WD40	<4..330	CDD:225201	65/282 (23%)
		WD40	14..260	CDD:238121	48/204 (24%)
		WD40 repeat	22..58	CDD:293791
		WD40 repeat	63..99	CDD:293791	6/35 (17%)
		WD40 repeat	106..142	CDD:293791	12/38 (32%)
		WD40 repeat	148..184	CDD:293791	11/35 (31%)
		WD40 repeat	192..228	CDD:293791	11/39 (28%)
		WD40 repeat	285..310	CDD:293791	4/28 (14%)
F47G4.4	NP_493453.1	WD40	<54..317	CDD:225201	68/311 (22%)
		WD40	54..>236	CDD:295369	47/198 (24%)
		WD40 repeat	56..91	CDD:293791	6/35 (17%)
		WD40 repeat	96..132	CDD:293791	12/39 (31%)
		WD40 repeat	140..174	CDD:293791	11/43 (26%)
		WD40 repeat	177..207	CDD:293791	8/29 (28%)
		WD40 repeat	215..258	CDD:293791	9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	83	1.000	Inparanoid score	I3767
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19845
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.980