DRSC/TRiP Functional Genomics Resources

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Protein Alignment kat80 and DAW1

DIOPT Version :9

Sequence 1:NP_523363.2 Gene:kat80 / 32581 FlyBaseID:FBgn0040207 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_849143.1 Gene:DAW1 / 164781 HGNCID:26383 Length:415 Species:Homo sapiens


Alignment Length:295 Identity:75/295 - (25%)
Similarity:117/295 - (39%) Gaps:56/295 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDCVRF--AYKDNFVY 76
            :|||...:|::.|.::|...:||..||...||.....|...:|.||...:..:.|  .|.|....
Human    88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIAT 152

  Fly    77 SADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCIKVC 141
            .:.| ...:.|.:.:.|.|.|..||...:..|.|||....|.:||.|||.:|||:||... :...
Human   153 GSFD-KTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE-VYTL 215

  Fly   142 RGHMSHVNSVKFSPDG-------------LWIASAGLEGSILI---------------------- 171
            |||.:.:.|:.|:..|             :|.|..|.:.:|||                      
Human   216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280

  Fly   172 -------WDIRKSKQIMEFIADPPVTAITCVQFHPFEF---LLAAGRVDGTVSIYDLEHQQLVSQ 226
                   ||....|.:............:|     |::   |:|....|||..|:....::.:::
Human   281 MDKTCKLWDATNGKCVATLTGHDDEILDSC-----FDYTGKLIATASADGTARIFSAATRKCIAK 340

  Fly   227 TTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWE 261
            .....|: |..|:|:..|..|..|||...:.| |:
Human   341 LEGHEGE-ISKISFNPQGNHLLTGSSDKTARI-WD 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kat80NP_523363.2 Katanin_con80 667..803 CDD:290636
WD40 <4..330 CDD:225201 75/295 (25%)
WD40 14..260 CDD:238121 74/292 (25%)
WD40 repeat 22..58 CDD:293791 11/35 (31%)
WD40 repeat 63..99 CDD:293791 8/37 (22%)
WD40 repeat 106..142 CDD:293791 15/35 (43%)
WD40 repeat 148..184 CDD:293791 12/77 (16%)
WD40 repeat 192..228 CDD:293791 8/38 (21%)
WD40 repeat 285..310 CDD:293791
DAW1NP_849143.1 eRF1 <22..>90 CDD:224420 0/1 (0%)
WD40 81..120 CDD:197651 11/31 (35%)
WD 1 90..129 12/38 (32%)
WD40 repeat 96..132 CDD:293791 11/35 (31%)
WD40 126..415 CDD:238121 62/257 (24%)
WD 2 132..174 10/42 (24%)
WD40 repeat 137..175 CDD:293791 8/38 (21%)
WD 3 175..214 17/39 (44%)
WD40 repeat 181..217 CDD:293791 15/36 (42%)
WD 4 217..256 8/38 (21%)
WD40 repeat 222..258 CDD:293791 7/35 (20%)
WD 5 259..298 3/38 (8%)
WD40 repeat 265..300 CDD:293791 3/34 (9%)
WD 6 301..340 8/43 (19%)
WD40 repeat 306..342 CDD:293791 8/40 (20%)
WD 7 343..384 11/33 (33%)
WD40 repeat 348..384 CDD:293791 10/27 (37%)
WD 8 386..415
WD40 repeat 390..414 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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