DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and AgaP_AGAP001159

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_322003.5	Gene:	AgaP_AGAP001159 / 1282009	VectorBaseID:	AGAP001159	Length:	803	Species:	Anopheles gambiae

Alignment Length:	919	Identity:	178/919 - (19%)
Similarity:	310/919 - (33%)	Gaps:	332/919 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALPRKLISKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSIDC 65
            :|:..:.:.|::.|: :|        |.|....:.||:::|::.                .|.|.
Mosquito    29 IAVAGRSLLKVFSIE-ND--------GFTEVCNMRGGKNQNLSY----------------SSNDV 68

  Fly    66 VRFAYKDNFVYSADDIGIIRRWDLN---SQKIYSTLNGHMKSVRTLDFN-PSGEYVVSGSNDTTV 126
            ...|...|.:.:|...|::..|||:   .||.....|.|.::..::.|: .....::|||.|.|:
Mosquito    69 AWSALDSNILATAATNGVVSVWDLSRFGRQKQLLVYNEHERTAHSVAFHGTEANLLISGSQDGTI 133

  Fly   127 RLWDVQNENNCIKVCRGHMSHVNSVKFSPDG-LWIASAGLEGSILIWDIRKSKQ-IMEFIA-DPP 188
            :.:|::.:.:.|.....:...|..|||||.. ...|:....|::.:||||::.: ..:|.| ..|
Mosquito   134 KCFDLRTDKSAINTYFSNSESVRDVKFSPHAPNTFAAVSENGTVQLWDIRRNDRCTAQFTAHSGP 198

  Fly   189 VTAITCVQFHPFEFLLAAGRVDGTVSIYDL-----EHQQL----VSQTTHFYGQAIRCITFSDNG 244
            :  .|| .:||.:..||.|..|..:.:::.     .|:..    :..|.|
Mosquito   199 I--YTC-DWHPNQSWLATGSRDKQIKVWNTNPKNSSHESAKNVSLEYTIH--------------- 245

  Fly   245 ECLFVGSSSGISVIG---WEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRV 306
                     .|:|:|   |.||: :.||.|.      ..||:|            ||....|.|
Mosquito   246 ---------TIAVVGRIRWRPDK-MFHIASC------ALVVDN------------SIYIWDLRR- 281

  Fly   307 IPFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVNE 371
             |:.  |.:..|...|.|...:| :||.:..|                    ||:...|  .:.:
Mosquito   282 -PYI--PYASFNEHSNVTTGIAF-KGNDRHVL--------------------LSTSKDS--TIFK 320

  Fly   372 AVLESAETSPMSSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGSSYGA 436
            .|.:.|....|.:.|                              ||.      |....|....|
Mosquito   321 HVFKDAARPAMKANP------------------------------QGA------NFNYKGDLLYA 349

  Fly   437 IDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFPVNQN 501
            .:.:|:....||||.......|....|...:..|   |:|..||   |:|:
Mosquito   350 YEMKLIPPPPPSSLLSQGTALLGSRQKTPPSAEQ---FHLAKSN---LSNF-------------- 394

  Fly   502 LNYITNNYKPVPATSTINASSKSIKKT------------------TTTTLHKRTTNNMAGAKQTS 548
                        :|.|||.::|.:.||                  |..:|.:..::|.|.||:
Mosquito   395 ------------STKTINVNAKDVTKTSLLKDYLALKGCAKEYILTGASLAEICSHNAAVAKK-- 445

  Fly   549 TGIFGGSKLS----------QVSSVSSMELHKLDDN--------MVLKKSSSSNVVNKNKRPMGS 595
               :|.|.:|          ..||:::|:|.:.:.|        ::.:.|:.|:......|.|||
Mosquito   446 ---YGKSNVSFLWNFISQLYAYSSIANMKLEQRNSNAIAHGSGRLMAQNSNQSSTGRSEDRAMGS 507

  Fly   596 ---------------------AQSQFSKENN---QQKNINVE----------------------- 613
                                 |.|:.:.|.:   |..::::|
Mosquito   508 GPSTGPANVANNSSTDDFLEFANSKTAHETHGLGQLLSVDIEPDKCDFVFGETELTFDSVDCIKG 572

  Fly   614 -----IITKPP--MRSRT--TLDMRTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEA-V 668
                 :.|.|.  ::..|  |.::..:|       ::||.||..:  :|.:...:.....:.| .
Mosquito   573 FRDGFLYTGPHDLVKDYTFPTSNLMNAH-------ELHQTQPRKH--LMAEKSLETSPPPNTAPT 628

  Fly   669 LQELSNRQSS----------LDLLRHATRSHDVLGALRQARSCGKSIFIDLLGAILEKPSSWNLD 723
            ..::|:...|          .|.|...|...||     |..||       :|.|:.|:..|..:|
Mosquito   629 FLKISDHNPSPPIWEPHQVLADCLTLQTEIGDV-----QTSSC-------ILMALGERRHSLQID 681

  Fly   724 --FCMFVLPEIYELLQSQHKFHFTRACDTLRIILSNFLPTIQENLDSWAANGLGVDVTREDRQRK 786
              |....|....|||. :|:. :..|...:.|              ||..:...::.........
Mosquito   682 ESFQENWLLSYIELLH-RHQL-WNEASQVINI--------------SWIRSVSEMNQQSTTMYTS 730

  Fly   787 CAECQRWLL 795
            |.:|.:.|:
Mosquito   731 CGQCSKQLV 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	29/142 (20%)
		WD40	<4..330	CDD:225201	76/344 (22%)
		WD40	14..260	CDD:238121	57/264 (22%)
		WD40 repeat	22..58	CDD:293791	5/35 (14%)
		WD40 repeat	63..99	CDD:293791	10/38 (26%)
		WD40 repeat	106..142	CDD:293791	8/36 (22%)
		WD40 repeat	148..184	CDD:293791	12/37 (32%)
		WD40 repeat	192..228	CDD:293791	9/44 (20%)
		WD40 repeat	285..310	CDD:293791	5/24 (21%)
AgaP_AGAP001159	XP_322003.5	WD40	14..318	CDD:295369	84/386 (22%)
		WD40	<39..318	CDD:225201	82/376 (22%)
		WD40 repeat	67..106	CDD:293791	10/38 (26%)
		WD40 repeat	112..150	CDD:293791	8/37 (22%)
		WD40 repeat	155..192	CDD:293791	12/36 (33%)
		WD40 repeat	200..243	CDD:293791	9/43 (21%)
		WD40 repeat	250..290	CDD:293791	16/62 (26%)
		Zn_ribbon_17	756..803	CDD:305234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910