DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and AgaP_AGAP010324

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_318239.4	Gene:	AgaP_AGAP010324 / 1278620	VectorBaseID:	AGAP010324	Length:	752	Species:	Anopheles gambiae

Alignment Length:	369	Identity:	75/369 - (20%)
Similarity:	140/369 - (37%)	Gaps:	104/369 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IKAHDSRVTSLDLGET---------GRVLVTGGEDRNVNLWAIGQ--NECFMSLTGHNRSIDCVR 67
            |..|..:::||:.||.         .:.:.|||:. .|..|.|.|  |:..:|      .:||::
Mosquito   453 IPRHARQISSLNHGEVVCAVTISNPTKYVYTGGKG-CVKAWDISQPGNKSPVS------QLDCLQ 510

  Fly    68 FAYKDNFVYS---------------ADDIGIIRRWDLNS--QKIYSTLNGHMKSVRTLDFNPSGE 115
               :||::.|               |.::.|   |||.|  .:|.:.|..:..:...|..:|..:
Mosquito   511 ---RDNYIRSVKLLPDGRTLIVGGEASNLSI---WDLASPTPRIKAELTSNAPACYALAISPDSK 569

  Fly   116 YVVSGSNDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQI 180
            ...|..:|..:.:||:||: ..::..:||....:.:..|.||..:.:.||:.::..||:|:.:|:
Mosquito   570 VCFSCCSDGNIAVWDLQNQ-TLVRQFQGHTDGASCIDISADGSKLWTGGLDNTVRSWDLREGRQL 633

  Fly   181 MEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGE 245
            .:                                              |.:...|..:.:...||
Mosquito   634 QQ----------------------------------------------HDFSSQIFSLGYCPTGE 652

  Fly   246 CLFVG-SSSGISVI-GWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVIP 308
            .|.|| .:|.:.|: ..:||:...|:..  |.:..:|..    .||...:.|      ..|.::.
Mosquito   653 WLAVGMENSNVEVLHATKPDKYQLHLHE--SCVLSLKFA----ACGKWFVST------GKDNLLN 705

  Fly   309 FYQPPNSLPNF--KHNSTNRKSFTRGNQKFRLSVGGAKPAQVQE 350
            .::.|.....|  |.:|:........:.|:.::..|.|.|.|.|
Mosquito   706 AWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYE 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	69/347 (20%)
		WD40	14..260	CDD:238121	56/275 (20%)
		WD40 repeat	22..58	CDD:293791	13/46 (28%)
		WD40 repeat	63..99	CDD:293791	12/52 (23%)
		WD40 repeat	106..142	CDD:293791	8/35 (23%)
		WD40 repeat	148..184	CDD:293791	9/35 (26%)
		WD40 repeat	192..228	CDD:293791	0/35 (0%)
		WD40 repeat	285..310	CDD:293791	4/24 (17%)
AgaP_AGAP010324	XP_318239.4	TLE_N	1..142	CDD:281857
		WD40	<464..750	CDD:225201	71/358 (20%)
		WD40	465..708	CDD:238121	61/314 (19%)
		WD40 repeat	469..508	CDD:293791	9/45 (20%)
		WD40 repeat	516..554	CDD:293791	9/40 (23%)
		WD40 repeat	559..595	CDD:293791	8/36 (22%)
		WD40 repeat	602..637	CDD:293791	9/80 (11%)
		WD40 repeat	642..675	CDD:293791	10/32 (31%)
		WD40 repeat	683..717	CDD:293791	6/43 (14%)
		WD40 repeat	724..748	CDD:293791	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910