DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and AgaP_AGAP007948

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_317524.4	Gene:	AgaP_AGAP007948 / 1278003	VectorBaseID:	AGAP007948	Length:	1059	Species:	Anopheles gambiae

Alignment Length:	762	Identity:	140/762 - (18%)
Similarity:	286/762 - (37%)	Gaps:	213/762 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LWAIGQN--ECFMSLTG---HNRS--------IDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIY 95
            |:.|.:|  :.|...||   ||..        |..|.......::|...:.|:|..|.::|
Mosquito    14 LFIIYENCIQAFSITTGELVHNYENSVNGSFLIGMVIDRTNSKYIYGCTNDGLIISWKIDS---- 74

  Fly    96 STLNGHM---KSVRTL--------DFNPSGEYVVSGSNDTTVRLWDVQNENNCIKVC-------R 142
            .||:|.|   |:.:.|        |.|..|.::::|::...:.:.....:...::|.       .
Mosquito    75 GTLSGKMEVLKNTKLLVESLHMMYDENGVGSFLIAGTSSKKMFIQYCPQKKKILQVVNAKLQTKE 139

  Fly   143 GHMSHVNS----VKFSP--DGL-WIASAGLEGSILIWDIRKSKQIMEFIADPPVT-----AITCV 195
            |.:.|:::    :..:|  ||| :.|...||.    |...:.|..:...:.|..:     .|.|
Mosquito   140 GDLDHIHAKNTHMLAAPGGDGLNYFAYIALER----WYWCRLKPSVYVNSRPHCSGVMPRVIVC- 199

  Fly   196 QFHPFEFLLAAGRVDGTVSIYD--LEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGISVI 258
              ||.|.::|.|...|.|.:|.  |:..:.:.:|.|::...::.:.|..:|...:.|....: |:
Mosquito   200 --HPTEPIVAVGDSIGRVVLYRNFLDQGRPIPETYHWHSLPVKTLAFGSSGTHFYSGGQERV-VV 261

  Fly   259 GWEPDRELDHIK-STWSSLAD--MKVV----NNKLICGCHEIDTVSINTISLDRVIPFYQPPNSL 316
            .|...:   |.| |....|:|  :.:|    |.||:....:.....:|.:.....|        :
Mosquito   262 KWNVGQ---HDKGSLIPRLSDTILHIVVGPENLKLVLCTADNGIQILNALHKQTAI--------V 315

  Fly   317 PNFKHNS---TNRKSFTRG---NQKFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVN----- 370
            .:|...|   |.::.|..|   |.:.:..|...:...:|......|:.|    |:|::.|
Mosquito   316 QSFSKTSSDITEKQLFPAGLRVNPRTQAIVLNGRVGCIQFFSTYSKNLL----YTLDITNRNYNT 376

  Fly   371 ---EAVLESAETSPMSSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGS 432
               :.|:.:...:.: ::....||::...|.:..        ::::.|:..||.   ::..:|
Mosquito   377 MEEKVVIHNTVVTNI-AINAYWLATVENWSDNQY--------SMETRLKFWKYD---ESHQTY-- 427

  Fly   433 SYGAIDTRLMSLNE--------PSSLHKPDI----------YNLYPLDKNEEAD----------- 468
               :::|.|.:::.        .||..:.|:          ..::.||..|.:|
Mosquito   428 ---SLNTNLENVHHGGVNDIAFSSSTRERDLQCATAGEDRRIKVWALDSVELSDGTEKLVWTCVG 489

  Fly   469 --------VQQLEFNLNDS-------------NPPIL---------NNYDNYEMAEDFPVNQNLN 503
                    |:.:.|:.:.|             |...|         ::||..       ||:.|.
Mosquito   490 SVQHRNLPVKSISFSQDASLLAGGFGNILCTWNTETLQLKCALSTPSSYDGC-------VNRALI 547

  Fly   504 YITNNYKPVPATSTINASSK--SIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSKLSQVSSVSSM 566
            .|       |.|:.:..|:|  :::||......:.||..:|        :..|.:.|.|....:.
Mosquito   548 MI-------PTTANVKKSAKNSTMEKTYDDMREEITTEMIA--------LMNGKERSVVLEKMNT 597

  Fly   567 ELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQK---NINVEIITKPPMRSRTTLDM 628
            ..:|....:..:|:::|:.:|        :.||..|:...||   |:.:.:..:..|.....:..
Mosquito   598 NRNKCQRIIRTRKNTASDNIN--------SLSQELKKMIVQKSAGNVQLNMAQRAEMFHTLAITC 654

  Fly   629 RTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNR 675
            ||:..|    ::|.||:.:.:|     .....:::|.|.:::.:..:
Mosquito   655 RTTDDA----RKIIQQKILTSR-----RSSRKINKSLEKIVENMDKQ 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	0/9 (0%)
		WD40	<4..330	CDD:225201	70/340 (21%)
		WD40	14..260	CDD:238121	55/260 (21%)
		WD40 repeat	22..58	CDD:293791	4/15 (27%)
		WD40 repeat	63..99	CDD:293791	8/35 (23%)
		WD40 repeat	106..142	CDD:293791	6/50 (12%)
		WD40 repeat	148..184	CDD:293791	9/42 (21%)
		WD40 repeat	192..228	CDD:293791	11/37 (30%)
		WD40 repeat	285..310	CDD:293791	4/24 (17%)
AgaP_AGAP007948	XP_317524.4	WD40	186..522	CDD:295369	63/371 (17%)
		WD40	195..>525	CDD:225201	63/365 (17%)
		WD40 repeat	241..277	CDD:293791	8/39 (21%)
		WD40 repeat	282..320	CDD:293791	7/45 (16%)
		WD40 repeat	325..368	CDD:293791	9/46 (20%)
		WD40 repeat	389..434	CDD:293791	8/61 (13%)
		WD40 repeat	441..490	CDD:293791	7/48 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910