DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and AgaP_AGAP006535

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_316573.2	Gene:	AgaP_AGAP006535 / 1277134	VectorBaseID:	AGAP006535	Length:	1170	Species:	Anopheles gambiae

Alignment Length:	338	Identity:	85/338 - (25%)
Similarity:	144/338 - (42%)	Gaps:	57/338 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALPRKLISKIYDI--KAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRSID 64
            |:| |.:.||:|.  |:..:.:.||.....|..||....|:.:....|..| ...||.||..::.
Mosquito     3 AIP-KWVEKIHDSSDKSDVASIHSLCYHPEGLQLVVAAGDKVLVYDPIDGN-LINSLKGHKDTVY 65

  Fly    65 CVRFAYKDNFVY---SADDIGIIRRWDLNSQKIYSTLN-GHMKSVRTLDFNPSGEYVVS-GSNDT 124
            ||.:| :|...:   |||...||  |   :||:...|. .|..|::.|.|||....:.| ..:|.
Mosquito    66 CVAYA-RDGKKFASGSADKTVII--W---TQKLEGLLKYSHNDSIQCLAFNPISHQLASCAVSDF 124

  Fly   125 TVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWD--------IRK----S 177
            :  .|  .:|...::..:. ::.:|:..::.||.:||.....|:|.|.:        |.:    :
Mosquito   125 S--FW--SSEQKAVQKYKS-VARINACAWTNDGQYIALGLANGTISIRNKAGEEKIKIERPGGPN 184

  Fly   178 KQIMEFIADPPVTA----ITCVQFHPFEFLLAAGRVD--GTVSIYDLEHQQLVSQTTHFYGQAIR 236
            ..|.....:||.|:    |.||             :|  .|:|.|.| ..|::.:..:|....:
Mosquito   185 SPIFGLAWNPPATSGSSDILCV-------------IDWAQTLSFYSL-GGQMIGKERNFAFDPL- 234

  Fly   237 CITFSDNGECLFV-GSSSGISVIGWEPDR--ELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSI 298
            |:||..|||.|.| |.:..:.:...:..|  .|.....:|...|.:....|.::.||.: .|:..
Mosquito   235 CLTFFPNGEFLIVAGCNKALQLFTRDGIRLGLLGEQHESWIWSAAVHPAGNCVVVGCQD-GTLGC 298

  Fly   299 NTISLDRVIPFYQ 311
            .|::.:.|...|:
Mosquito   299 YTLAFNTVHALYR 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	84/336 (25%)
		WD40	14..260	CDD:238121	68/271 (25%)
		WD40 repeat	22..58	CDD:293791	10/35 (29%)
		WD40 repeat	63..99	CDD:293791	12/38 (32%)
		WD40 repeat	106..142	CDD:293791	8/36 (22%)
		WD40 repeat	148..184	CDD:293791	10/47 (21%)
		WD40 repeat	192..228	CDD:293791	9/37 (24%)
		WD40 repeat	285..310	CDD:293791	5/24 (21%)
AgaP_AGAP006535	XP_316573.2	WD40	<4..299	CDD:225201	81/323 (25%)
		WD40	21..296	CDD:295369	74/302 (25%)
		WD40 repeat	65..99	CDD:293791	13/39 (33%)
		WD40 repeat	104..136	CDD:293791	8/35 (23%)
		WD40 repeat	144..180	CDD:293791	9/35 (26%)
		WD40 repeat	187..222	CDD:293791	12/48 (25%)
		WD40 repeat	230..268	CDD:293791	10/38 (26%)
		WD40 repeat	275..296	CDD:293791	4/21 (19%)
		P-loop_NTPase	<659..>844	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910