DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and AgaP_AGAP006042

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_316089.4	Gene:	AgaP_AGAP006042 / 1276713	VectorBaseID:	AGAP006042	Length:	1030	Species:	Anopheles gambiae

Alignment Length:	449	Identity:	94/449 - (20%)
Similarity:	142/449 - (31%)	Gaps:	144/449 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTV 126
            |||.|......|  .|||...:         :....||.|...|....|:|.|..:.:||.|.:|
Mosquito   615 SIDSVSLLVDHN--CSADGFPL---------QPLQVLNDHSDEVWFCKFSPDGRRLATGSKDNSV 668

  Fly   127 RLWDVQNENNCIKVCR---GHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPP 188
            .:|:|......::..|   ||...|:.:.:|||.....:.|.:....:|
Mosquito   669 IVWEVDPVKLLLRNKRSFEGHTYGVSYIAWSPDSKHFIACGPDDCPDLW---------------- 717

  Fly   189 VTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSS 253
                                      |:|:|.::||::.:|....::.|..|:.:|.....|.:.
Mosquito   718 --------------------------IWDVEQEKLVTKFSHSTDDSLTCAAFNRDGTRFVTGGTR 756

  Fly   254 G----ISVIG-----WEPDRELDHIKSTWSSLADMKVVNNKLICGCH-EIDTVSINTISLDRVIP 308
            |    :.:.|     ||..|     .:..|.|:|.|.|   |....| .|...|.:....|..|.
Mosquito   757 GQFYLVDLDGILHDNWEGVR-----VNGLSFLSDNKTV---LAADTHYRIRGYSFDNPRTDYGIV 813

  Fly   309 FYQPPNSLPNFKHNSTNR-------------------------KSFTRGNQKFRLSVGGAKPAQV 348
            ..|.|  :..|..||.:|                         :..|:||.......||...:.|
Mosquito   814 QEQCP--IMTFSVNSADRLALLNISSQGLHLWDLQDKCLVRRFQGVTQGNYTIYSCFGGVNESFV 876

  Fly   349 QEEHEGDKSGLSSPNYSLEVVNEAVLES----AETSPMSSLPPVHLASMAGSSAD---------- 399
            ....|.:|.      |...:..|..|.:    ..|....|..||:.|.:|.:|.|
Mosquito   877 ASGSEDNKV------YIWHIRREEPLATLIGHTRTVNCVSWNPVYPALLASASDDGTVRIWGPQQ 935

  Fly   400 ---------------LAPHHVVY--------GGAIDSALRQGKYSRVPDNMASYGSSYG 435
                           |..|..|:        |||.|||......|....:.::..||.|
Mosquito   936 PPTQWTANGSGVANTLQHHPQVHTNGSGGGVGGAADSASISSTGSATSTSSSTSSSSGG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	62/305 (20%)
		WD40	14..260	CDD:238121	42/209 (20%)
		WD40 repeat	22..58	CDD:293791
		WD40 repeat	63..99	CDD:293791	7/35 (20%)
		WD40 repeat	106..142	CDD:293791	9/35 (26%)
		WD40 repeat	148..184	CDD:293791	6/35 (17%)
		WD40 repeat	192..228	CDD:293791	5/35 (14%)
		WD40 repeat	285..310	CDD:293791	6/25 (24%)
AgaP_AGAP006042	XP_316089.4	LisH	426..455	CDD:128913
		CTLH	464..518	CDD:128914
		WD40	<633..931	CDD:225201	73/364 (20%)
		WD40	636..931	CDD:238121	73/352 (21%)
		WD40 repeat	648..688	CDD:293791	10/39 (26%)
		WD40 repeat	693..731	CDD:293791	11/79 (14%)
		WD40 repeat	739..773	CDD:293791	6/33 (18%)
		WD40 repeat	777..855	CDD:293791	17/82 (21%)
		WD40 repeat	864..900	CDD:293791	8/41 (20%)
		WD40 repeat	906..931	CDD:293791	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910