DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and KATNB1

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_005877.2	Gene:	KATNB1 / 10300	HGNCID:	6217	Length:	655	Species:	Homo sapiens

Alignment Length:	842	Identity:	227/842 - (26%)
Similarity:	352/842 - (41%)	Gaps:	224/842 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALP--RKLISKIYDIKAHDSRVTSLDLGE-TGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRS 62
            ||.|  .|...|:.:|.||.|.|:||.||: :||:|.|||:|..||||:|.:..|.||||||...
Human     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65

  Fly    63 IDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVR 127
            ::.||....:..:.:....|.||.|||.:.||..||.||..::.:|||:|.||:|.|||.||.::
Human    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130

  Fly   128 LWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTA- 191
            |||::.: .|:...|||...|..::|||||.|:|||..:.::.:||:...|.:.||   |..|.
Human   131 LWDIRRK-GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF---PGHTGP 191

  Fly   192 ITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGIS 256
            :..|:|||.|:|||:|..|.|:..:|||..|:||......| .:|.:.|:.:|.||:.|....:.
Human   192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG-PVRSVLFNPDGCCLYSGCQDSLR 255

  Fly   257 VIGWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVI-------------- 307
            |.||||:|..|.:...|..:||:.:.|::||........||...:.|.||.
Human   256 VYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHR 320

  Fly   308 PFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVNEA 372
            |..||   |||  .::..|:.:.|.      |...:||.:|::..|.::...||.:...|..:.|
Human   321 PLAQP---LPN--PSAPLRRIYERP------STTCSKPQRVKQNSESERRSPSSEDDRDERESRA 374

  Fly   373 VLESAET-----SPMSSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGS 432
            .:::||.     .|.:|:                                   ||.|...
Human   375 EIQNAEDYNEIFQPKNSI-----------------------------------SRTPPRR----- 399

  Fly   433 SYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFP 497
                        :||           :|....::|...:      ::..|      :..|...||
Human   400 ------------SEP-----------FPAPPEDDAATAK------EAAKP------SPAMDVQFP 429

  Fly   498 VNQNLNYITNNYKPVPATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSKLSQVSS 562
            | .||..:..  .||.|::....:..:|...|
Human   430 V-PNLEVLPR--PPVVASTPAPKAEPAIIPAT--------------------------------- 458

  Fly   563 VSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMRSRTTLD 627
                                      ...|:|...|.|                .|.::
Human   459 --------------------------RNEPIGLKASDF----------------LPAVK------ 475

  Fly   628 MRTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQSSLDLLRHATRSHDVL 692
                         |.||..     ::|:.....:.:.|:.:...|::|..:||.:|......|:.
Human   476 -------------IPQQAE-----LVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGDIK 522

  Fly   693 GALRQARSCGK-SIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILS 756
            .::..|.:... |:.:|||..:.:|.|.|.||.|..|||:|.:||||:::.:....|.:|::||.
Human   523 TSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQ 587

  Fly   757 NFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPEST-----HFGSTLSQL 813
            .|||.|.:.|.  |...:|||::||:|..||..|.:.|..|..|.:|.     ..|||..:|
Human   588 RFLPLITDMLA--APPSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFREL 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	47/136 (35%)
		WD40	<4..330	CDD:225201	130/343 (38%)
		WD40	14..260	CDD:238121	103/247 (42%)
		WD40 repeat	22..58	CDD:293791	20/36 (56%)
		WD40 repeat	63..99	CDD:293791	11/35 (31%)
		WD40 repeat	106..142	CDD:293791	16/35 (46%)
		WD40 repeat	148..184	CDD:293791	14/35 (40%)
		WD40 repeat	192..228	CDD:293791	17/35 (49%)
		WD40 repeat	285..310	CDD:293791	8/38 (21%)
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		122/303 (40%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		118/287 (41%)
		WD40	7..257	CDD:238121	104/254 (41%)
		WD40 repeat	67..103	CDD:293791	12/35 (34%)
		WD40 repeat	108..144	CDD:293791	16/36 (44%)
		WD40 repeat	151..186	CDD:293791	14/37 (38%)
		WD40 repeat	192..228	CDD:293791	17/35 (49%)
		WD40 repeat	234..261	CDD:293791	9/26 (35%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		41/235 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..422		29/196 (15%)
		DNA_pol3_gamma3	<386..>494	CDD:331207	30/284 (11%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		68/318 (21%)
		Katanin_con80	497..648	CDD:316447	52/153 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142071
Domainoid	1	1.000	87	1.000	Domainoid score	I8041
eggNOG	1	0.900	-	-		E1_KOG0267
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4302
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2507
Isobase	1	0.950	-	0	Normalized mean entropy	S3791
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159977at33208
OrthoFinder	1	1.000	-	-		FOG0006599
OrthoInspector	1	1.000	-	-		oto91014
orthoMCL	1	0.900	-	-		OOG6_103099
Panther	1	1.100	-	-	LDO	PTHR19845
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.750