DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and Tle7

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001357768.1	Gene:	Tle7 / 102638837	MGIID:	5439433	Length:	430	Species:	Mus musculus

Alignment Length:	290	Identity:	63/290 - (21%)
Similarity:	111/290 - (38%)	Gaps:	58/290 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WAIGQNECFMSLTGHNRSIDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRT-L 108
            |.:|       ...|.:.::.:..:.....||:. ..|.||.||.|:      |:...::.:. |
Mouse   139 WRVG-------TLRHGKRVNAIAISSAPCHVYTC-GTGYIRVWDENA------LHASDRAPQAQL 189

  Fly   109 DFN------------PSGEYVVSGSNDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIA 161
            ||.            |..:.:::|.....:.|||:.....    .|..|:...|:.:|   |.::
Mouse   190 DFQDPRNRVLTCKLFPDEQSLITGGMARGLTLWDLAPTPQ----VRAQMASTGSICYS---LALS 247

  Fly   162 S------AGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEH 220
            |      |..:|.:.|||::  .||:....:.|..|..||....|:|.  .|..|.|:..:||..
Mouse   248 SDAHLCLASFKGFVEIWDVQ--NQILIRKHEVPPYASRCVDITGFKFW--TGGEDTTLYSWDLRS 308

  Fly   221 QQLVSQTTHFYGQAIRCITFSDNGECLFVG-SSSGISVIGWEPDRELDHIKSTWSSLADMKVVNN 284
            .|.:.|  |.....|..||...:.|.:..| ..|.:.::....:.:...|...::...::|..:
Mouse   309 YQKLQQ--HSLCHEILSITHDPSEEWVLAGLKMSDVVILHAHREEKYKAIVQRYTQHHNLKFAS- 370

  Fly   285 KLICGCHEIDTVSINTISLDRVIPFYQPPN 314
               ||.:.:.|       ||.||.....|:
Mouse   371 ---CGTYFMAT-------LDEVIHCLAAPS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	63/290 (22%)
		WD40	14..260	CDD:238121	53/234 (23%)
		WD40 repeat	22..58	CDD:293791	2/12 (17%)
		WD40 repeat	63..99	CDD:293791	8/35 (23%)
		WD40 repeat	106..142	CDD:293791	8/48 (17%)
		WD40 repeat	148..184	CDD:293791	11/41 (27%)
		WD40 repeat	192..228	CDD:293791	11/35 (31%)
		WD40 repeat	285..310	CDD:293791	7/24 (29%)
Tle7	NP_001357768.1	WD40	<146..422	CDD:225201	61/276 (22%)
		WD40 repeat	152..191	CDD:293791	10/45 (22%)
		WD40 repeat	199..236	CDD:293791	7/40 (18%)
		WD40 repeat	241..275	CDD:293791	10/38 (26%)
		WD40 repeat	283..316	CDD:293791	11/36 (31%)
		WD40 repeat	321..361	CDD:293791	7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910