DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kat80 and edc4

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_002935417.2	Gene:	edc4 / 100379843	XenbaseID:	XB-GENE-5839769	Length:	1383	Species:	Xenopus tropicalis

Alignment Length:	1042	Identity:	206/1042 - (19%)
Similarity:	354/1042 - (33%)	Gaps:	348/1042 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ISKIYD----IKAHDSRVTSLDLGETGRVLVTGGEDRNVNLWAI---GQNE--CFMSLTGHN-RS 62
            :|:|.:    :|.|..|::...|...|.||.|...|..|..|.|   ||::  |......|| |.
Frog   280 VSEIKEGFIIVKGHSGRLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDQPRCLHEWKPHNGRP 344

  Fly    63 IDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVR 127
            :.|:.|.  ||                           |.|....:   |...::::|:
Frog   345 LSCLLFC--DN---------------------------HKKQDPEV---PFWRFLITGA------ 371

  Fly   128 LWDVQNENNCIKV-CRGHMSHVNSVKFSPD--------GLWIASAGLEGSILI-WDI-RKSKQIM 181
                 ::|..:|| |....:.:.:::||||        || .||..|....|| .|: ||...:|
Frog   372 -----DQNRELKVWCTVSWTSLQTIQFSPDPFSSGILPGL-KASLDLSAEFLILTDVQRKVLYVM 430

  Fly   182 EF--IADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNG 244
            |.  ..|......|.:.    ||||....:  :..|.|:.|.:|.:.......:....|:..:..
Frog   431 ELKQNQDEGKATFTSIS----EFLLTHPVL--SFGIQDVNHCRLRNTEVLPSEEDNNSISQEEPL 489

  Fly   245 ECLFVGSSSGI---------------------------SVIGW-EPDRE----LDHIK------- 270
            ||..|.|::|:                           :::|. :|.:|    .|||:
Frog   490 ECESVESAAGVLIKLFCVHTKALQDVQIWFQPRQNTEPAILGTSQPTQEDFALPDHIQGINKERM 554

  Fly   271 -STWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVI---PFYQPPNSLPN------------- 318
             ||..||..    :...:|.. ..|.:.::|.|..:::   .|..|..||..
Frog   555 SSTQGSLHG----SQSELCRI-TTDFLLLSTDSAPKLMTPDAFMSPSVSLQQGISSPGSIISTLT 614

  Fly   319 ----FKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEG----------------DKSGLSSP- 362
                ..:.|::....:|.:::..||.    ..|:....:|                .::.:|.|
Frog   615 AVTPISNTSSSDTVLSRPSEEMTLST----MLQLDTSRDGTLQSSSRNSAVVIPGMSETSVSKPA 675

  Fly   363 ------NYSLE-------VVNEA---------VLESAETSPMSSLPPVHLASMAGSSADLAPHHV 405
                  |:.||       ||.:|         |:.||.|:....:|.:...::..|.....|..:
Frog   676 AQLVSSNHPLELQDLDPLVVPQASPTRERSPDVISSASTAIPQDIPEIASETLQRSYISSVPLGL 740

  Fly   406 VYGGAIDSALRQGKYSRVPDNMASYGSSYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQ 470
            ...|. ||       |...|:|:|..|:...:....:||:..   |:|.|.....:: ||..:..
Frog   741 SVEGC-DS-------SHHSDSMSSAASALHLLSPHNLSLDHG---HRPIIIGSSVVE-NERINAP 793

  Fly   471 Q-LEFNLNDSN------------PPIL----NNYDNYEMAEDFPVNQNLNYITNNYKPVPATSTI 518
            . ||..:.:.|            |.|.    |:.|:....:|...|   ::..:||..:....:.
Frog   794 SLLESKIQEDNVDIGLPQPWPAAPDITKETRNSLDSSRNGQDRGDN---SFHRHNYHLLQQHDSQ 855

  Fly   519 NASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGG-----------SKLSQVSSVSSMELHKLD 572
            :||::.       :.|.....::|    :.:|.|||           ||||..||..
Frog   856 DASAEQ-------SDHDDEVASLA----SISGSFGGKGQHLPIKDWKSKLSPRSSPK-------- 901

  Fly   573 DNMVLKKSSSSNVVNKNKRPMGS---AQSQFSKE-----NNQQKNI------NVEIITKPPMRSR 623
                |::.|..:.:...:.|..|   |..:..:|     .||||.:      .:|::.|......
Frog   902 ----LRRKSKKDEMELTQSPRISDHMANYELQEELLCMLRNQQKELCDLRQNQLELMKKLTDHMD 962

  Fly   624 TTLDMRTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQS-SL-----DLL 682
            ........|..:..:.|..|:|....||:.|.|:.:  .:..|.:.|:||:..| ||     .::
Frog   963 AVQSSIMGHVERVIDTQQEQEQRRVERILSDGHERN--GQLQEYLSQQLSHSLSGSLCNRVDKII 1025

  Fly   683 RH---------ATRSHD----------------VLGALRQ-----------ARSCGKSIFIDLLG 711
            |.         .|::.|                |.|.|::           ..:.|: :..:.|.
Frog  1026 REEMKKTISQCITKTLDPVTAQLTSTVAAKVTAVEGVLKENVTKMVKSKNVTDAIGR-VAAESLQ 1089

  Fly   712 AILEKPSSWNLDFCMFVLPEIYELLQS-------------------------QHKFHFTRACDTL 751
            |:::  ||:...|...|||......||                         ..|.:.....|.|
Frog  1090 AVIQ--SSYREAFQSIVLPAFERSCQSMFQQINGSFKQGTQEYMQQLEAHLRSRKMNEQETRDPL 1152

  Fly   752 RIILSNFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWL-LQIKNLPESTHFGSTLSQLQN 815
            ...|...:.::|...|..|:|     :....|    .|.|..: :.:.|:.:     |.|||:|.
Frog  1153 VTQLQQMVDSLQSITDQLASN-----IASNVR----TEVQHQIHIAVGNMQD-----SILSQVQR 1203

  Fly   816 II 817
            ||
Frog  1204 II 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636	35/203 (17%)
		WD40	<4..330	CDD:225201	83/404 (21%)
		WD40	14..260	CDD:238121	62/291 (21%)
		WD40 repeat	22..58	CDD:293791	12/40 (30%)
		WD40 repeat	63..99	CDD:293791	4/35 (11%)
		WD40 repeat	106..142	CDD:293791	5/36 (14%)
		WD40 repeat	148..184	CDD:293791	16/47 (34%)
		WD40 repeat	192..228	CDD:293791	9/35 (26%)
		WD40 repeat	285..310	CDD:293791	4/27 (15%)
edc4	XP_002935417.2	Ge1_WD40	111..436	CDD:374606	48/199 (24%)
		WD40 repeat	176..215	CDD:293791
		WD40 repeat	301..339	CDD:293791	12/37 (32%)
		PLN03119	<783..882	CDD:178666	21/113 (19%)
		Muted	<936..1031	CDD:373409	22/96 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910