DRSC/TRiP Functional Genomics Resources

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Protein Alignment kat80 and apaf1

DIOPT Version :9

Sequence 1:NP_523363.2 Gene:kat80 / 32581 FlyBaseID:FBgn0040207 Length:819 Species:Drosophila melanogaster
Sequence 2:XP_012815297.2 Gene:apaf1 / 100127738 XenbaseID:XB-GENE-988968 Length:1248 Species:Xenopus tropicalis


Alignment Length:353 Identity:80/353 - (22%)
Similarity:140/353 - (39%) Gaps:75/353 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SKIYDIKAHDSRVTSLDLGETGRVLVTGGEDRNVNLW---------------------------- 45
            :||.|..||.|.|..:.........:|..:|:.|.||                            
 Frog   869 TKIADFNAHLSWVHCVKFSPKSSSFLTSSDDQTVKLWETSNVSKPAATNLKREFDVTFSGERTLV 933

  Fly    46 -AIGQNECFM---SLTGHNRSIDCVRFAYKDNFV--------YSADDI----GIIRRWDLNSQKI 94
             |..:::|.:   .:||...|    :...:||.|        |....|    |.::..||:..:|
 Frog   934 LATSKDDCILLINGMTGETLS----QIRAQDNCVTCCCLSTDYQLAAIGHRDGKVKILDLSGGEI 994

  Fly    95 YSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLW 159
            ...|:||..:|:...|...|:.:||.|:|.|||:|::.:..| :::| ||...|...|...:.. 
 Frog   995 LHKLDGHRDTVQHCQFTADGKLLVSSSDDCTVRVWNLVSGKN-LELC-GHKEPVKFFKILQESK- 1056

  Fly   160 IASAGLEGSILIWDIRKSKQIMEFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLV 224
            :.|...:|::.:|::...:.|.|||.. ..|.:.| ...|.....::...|.:..|:.|::..|:
 Frog  1057 VFSWSFDGTVKVWNLLTGQLIKEFICH-SATVLAC-DISPDSTKFSSASTDKSAKIWSLDNCALL 1119

  Fly   225 SQTTHFYGQAIRCITFSDNGECLFVGSSSGISVIGWEPDRELDHIKSTWSSLADMKVVNNKLICG 289
            .:... :...:||..||.:.:.|..|..||..:|              ||      |.|.:|:..
 Frog  1120 HELNK-HQSCVRCCRFSWDNQYLATGDDSGKIMI--------------WS------VQNGELLRE 1163

  Fly   290 CHEIDTVSINTISLDRVIPF-YQPPNSL 316
            |.::...:.|::....|... :.|.|.|
 Frog  1164 CCDVSVNNENSLHDGWVTDLHFSPDNKL 1191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kat80NP_523363.2 Katanin_con80 667..803 CDD:290636
WD40 <4..330 CDD:225201 80/353 (23%)
WD40 14..260 CDD:238121 66/289 (23%)
WD40 repeat 22..58 CDD:293791 7/67 (10%)
WD40 repeat 63..99 CDD:293791 9/47 (19%)
WD40 repeat 106..142 CDD:293791 11/35 (31%)
WD40 repeat 148..184 CDD:293791 7/35 (20%)
WD40 repeat 192..228 CDD:293791 6/35 (17%)
WD40 repeat 285..310 CDD:293791 4/25 (16%)
apaf1XP_012815297.2 DD 7..92 CDD:417479
NB-ARC 131..374 CDD:395745
APAF1_C 453..587 CDD:407760
WD40 610..906 CDD:238121 11/36 (31%)
WD40 repeat 619..655 CDD:293791
WD40 repeat 660..697 CDD:293791
WD40 repeat 703..741 CDD:293791
WD40 repeat 746..788 CDD:293791
WD40 repeat 800..875 CDD:293791 3/5 (60%)
WD40 871..1203 CDD:238121 79/351 (23%)
WD40 repeat 881..916 CDD:293791 6/34 (18%)
WD40 repeat 921..957 CDD:293791 5/39 (13%)
WD40 repeat 963..1000 CDD:293791 8/36 (22%)
WD40 repeat 1006..1041 CDD:293791 12/36 (33%)
WD40 repeat 1046..1080 CDD:293791 6/34 (18%)
WD40 repeat 1088..1123 CDD:293791 6/35 (17%)
WD40 repeat 1129..1170 CDD:293791 15/60 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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