DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kat80 and tle1

DIOPT Version :9

Sequence 1:	NP_523363.2	Gene:	kat80 / 32581	FlyBaseID:	FBgn0040207	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001163974.1	Gene:	tle1 / 100101799	XenbaseID:	XB-GENE-868100	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	69/333 - (20%)
Similarity:	131/333 - (39%)	Gaps:	71/333 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IKAHDSRVTSLDLGET---------GRVLVTGGEDRNVNLWAIGQ--NECFMSLTGHNRSIDCVR 67
            |..|..::.:|:.||.         .|.:.|||:. .|.:|.|.|  |:..:|      .:||:.
Frog   481 IPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKG-CVKVWDISQPGNKSPVS------QLDCLN 538

  Fly    68 FAYKDNFVYS------------ADDIGIIRRWDL--NSQKIYSTLNGHMKSVRTLDFNPSGEYVV 118
               :||::.|            ..:...:..|||  .:.:|.:.|.....:...|..:|..:...
Frog   539 ---RDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCF 600

  Fly   119 SGSNDTTVRLWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIM-- 181
            |..:|..:.:||:.|: ..::..:||....:.:..|.||..:.:.||:.::..||:|:.:|:.
Frog   601 SCCSDGNIAVWDLHNQ-TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH 664

  Fly   182 EFIADPPVTAITCVQFHPFEFLLAAGRVDGTVSIYDL---EHQQLVSQTTHFYGQAIRCITFSDN 243
            :|     .:.|..:.:.|....||.|.....|.:..:   :..||     |.:...:..:.|:..
Frog   665 DF-----TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQL-----HLHESCVLSLKFAYC 719

  Fly   244 GECLFVGSSSGISVIGWEPDRELDHIKSTW-----SSLADMKVVNNKLICGCHEIDTVSINTISL 303
            |:              |......|::.:.|     :|:...|..::.|.|.. .||...|.|.|.
Frog   720 GK--------------WFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDI-SIDDKYIVTGSG 769

  Fly   304 DRVIPFYQ 311
            |:....|:
Frog   770 DKKATVYE 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kat80	NP_523363.2	Katanin_con80	667..803	CDD:290636
		WD40	<4..330	CDD:225201	69/333 (21%)
		WD40	14..260	CDD:238121	55/275 (20%)
		WD40 repeat	22..58	CDD:293791	13/46 (28%)
		WD40 repeat	63..99	CDD:293791	9/49 (18%)
		WD40 repeat	106..142	CDD:293791	7/35 (20%)
		WD40 repeat	148..184	CDD:293791	9/37 (24%)
		WD40 repeat	192..228	CDD:293791	8/38 (21%)
		WD40 repeat	285..310	CDD:293791	8/24 (33%)
tle1	NP_001163974.1	TLE_N	1..143	CDD:281857
		WD40	<486..778	CDD:225201	67/328 (20%)
		WD40	493..777	CDD:238121	65/319 (20%)
		WD40 repeat	497..536	CDD:293791	10/45 (22%)
		WD40 repeat	544..582	CDD:293791	6/37 (16%)
		WD40 repeat	587..623	CDD:293791	7/36 (19%)
		WD40 repeat	630..665	CDD:293791	9/34 (26%)
		WD40 repeat	670..703	CDD:293791	6/32 (19%)
		WD40 repeat	711..745	CDD:293791	6/47 (13%)
		WD40 repeat	752..776	CDD:293791	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910