DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment disco and Bnc2

DIOPT Version :9

Sequence 1:NP_001033847.1 Gene:disco / 32579 FlyBaseID:FBgn0000459 Length:568 Species:Drosophila melanogaster
Sequence 2:NP_001100136.1 Gene:Bnc2 / 298189 RGDID:1310694 Length:1106 Species:Rattus norvegicus


Alignment Length:454 Identity:127/454 - (27%)
Similarity:171/454 - (37%) Gaps:140/454 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 RRWGSPPINLAGQFINPATGKKRVQCSICFKTFCDKGALKIHFSAVHLREMHKCTVEGCNMVFSS 133
            ||.||            |:.|.||.|:.|.|||.|||.||||::||||:..|:||:|||||||||
  Rat   437 RRMGS------------ASRKGRVFCNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSS 489

  Fly   134 RRSRNRHSANPNPKLHSPHIRRK------------ISPHDGRTAQQFPVFSPG-------TAAAA 179
            .||||||||||||:||.|.:|..            .:|....|.....:.|||       |....
  Rat   490 LRSRNRHSANPNPRLHMPMLRNNRDKDLIRATSGAATPVIASTKSNLTLTSPGRPPMGFTTPPLD 554

  Fly   180 AAVAGRLP--VAFPGL-------------------------LP--------------PPPPHHGH 203
            ..:...||  :.|.||                         ||              ||||....
  Rat   555 PVLQNPLPSQLVFSGLKTVQPVPPFYRSLLTPGEMVSPPTSLPTSPIIPTSGTIEQHPPPPSEPI 619

  Fly   204 HPYVMFGGQAGLHGLGLLSTGCQDPDSGS---------VDNEQDADPEDD--ND--FVYVDM--- 252
            .|.||.    |.|..|......:.|...|         :|...:.|.|||  ||  .|..||   
  Rat   620 VPAVMM----GTHEPGADLAPKKKPRKSSMPVKIEKEIIDTADEFDDEDDDPNDGGTVVNDMSHG 680

  Fly   253 ----QANSSSPAASSEDQEEHERDNEQDEEMHCSLSLASSSSIAADEERAADQPLDFSLHKRRKS 313
                ..:..||..|.:|..:|.|                :..|:..|.|.||.          .:
  Rat   681 NHCHSQDEMSPGMSVKDFSKHNR----------------TRCISRTEIRRADS----------MT 719

  Fly   314 EQDREQEQEQEQEREREAEKEQEQDVESDKEHEPEQEHEL----EREKRSPSDAFSMDQLLGKRK 374
            .:|:|.|::.|.|.|....|..|:.:..|:....|...::    ||...:.|:....|.:..|.:
  Rat   720 SEDQEPERDYENESESSEPKLGEESMVEDEHIHSEVSDKVLMNSERADENHSEPSHQDVIKVKEE 784

  Fly   375 RHDST-----------ASSSACSTAAASSASSSSASASANPPQTSIKMDL--DPDSDSAYMTSR 425
            ..|.|           .:....|.||...:.:||.: ..:|.:.|.:.||  .||....|:..:
  Rat   785 FTDPTYDMFYMSQYGLYNGGGASMAALHDSFTSSLN-YGSPQKFSPEGDLCSSPDPKICYVCKK 847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
discoNP_001033847.1 None
Bnc2NP_001100136.1 C2H2 Zn finger 450..471 CDD:275368 13/20 (65%)
C2H2 Zn finger 478..496 CDD:275368 15/17 (88%)
C2H2 Zn finger 842..863 CDD:275368 1/6 (17%)
C2H2 Zn finger 870..888 CDD:275368
C2H2 Zn finger 1044..1065 CDD:275368
C2H2 Zn finger 1072..1090 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166352834
Domainoid 1 1.000 81 1.000 Domainoid score I8332
eggNOG 1 0.900 - - E1_2C0EZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D59377at33208
OrthoFinder 1 1.000 - - FOG0002551
OrthoInspector 1 1.000 - - mtm9145
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15021
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.940

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