DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment disco and bnc2

DIOPT Version :9

Sequence 1:	NP_001033847.1	Gene:	disco / 32579	FlyBaseID:	FBgn0000459	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_002935715.2	Gene:	bnc2 / 100494907	XenbaseID:	XB-GENE-953157	Length:	1022	Species:	Xenopus tropicalis

Alignment Length:	562	Identity:	143/562 - (25%)
Similarity:	206/562 - (36%)	Gaps:	185/562 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MNPFMSPAYLLGHGPH----SHQHVHSHLPSH---------------PQP----------NAAS- 39
            :||..:|  :||..|:    .|..:....||:               |.|          ||.|
Frog   250 INPVSAP--MLGLPPNGLMLEHPGLRLREPSNSNQNECEESSESEVSPMPYSRNEQPSNRNALSS 312

  Fly    40 -----PASSPGGSSG---SGSGSAAGSGTGSGSSLK---PRRWGSPPINLAGQFINPATGKKRVQ 93
                 |.:.|..:|.   |...|.......:.:|.|   .||.||            ::.|.||.
Frog   313 ITNVEPKTEPTNASPTQCSTPVSEINKSEHTKTSFKIHRMRRMGS------------SSRKGRVF 365

  Fly    94 CSICFKTFCDKGALKIHFSAVHLREMHKCTVEGCNMVFSSRRSRNRHSANPNPKLHSPHIRRK-- 156
            |:.|.|||.|||.||||::||||:..|:||:|||||||||.||||||||||||:||.|.:|..
Frog   366 CNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMLRNNRD 430

  Fly   157 ----------ISPHDGRTAQQFPVFSPGTAAAAAAVAGRLPV---------AFPGL--LPPPPPH 200
                      .:|....|.....:.|||......:.....|:         .||.|  :.|.||.
Frog   431 KDLIRATSGAATPVIASTKSSLTLTSPGRPPLGFSTPPLDPILQNTLSNHLVFPALKTVQPVPPF 495

  Fly   201 H------GHHPYVMFGGQAGLHGLGLL--STGCQDP------------DSGSV------DNEQDA 239
            :      |.    |......|....::  |.|.:.|            .|||:      |:..|.
Frog   496 YRSLLNSGD----MVSPPTSLPTSPIMPSSLGVEQPLPLPPSLPLPSELSGSMIGVTIHDSNADQ 556

  Fly   240 DPEDDNDFVYVDMQANSSSP---------AASSEDQEEHE------------RDNEQDEEMHCSL 283
            .|:        .....||.|         .|...|:||.|            .|:...::|...|
Frog   557 APK--------KKPRKSSMPVKIEKEVIDTADEFDEEEEENIDHGPSTNDMGHDSHSQDDMSPGL 613

  Fly   284 SLAS------SSSIAADEERA-----ADQPLDFSLHKRRKSEQDREQEQEQEQEREREAEKEQEQ 337
            |:.|      |..|...:.||     .||            |.||:.|.|......:..::..|.
Frog   614 SVNSFSKNSGSRCIRRTDTRANSVTSEDQ------------EHDRDFENESVSSEPKYCDEPMED 666

  Fly   338 D-------------VESDKEHEP----EQEHELEREKRSPSDAFSMDQLLGKRKRHDSTASSSAC 385
            |             :::||.:|.    .|:..::.::.....|:.|..:......:.::||.:|.
Frog   667 DHLPLHKEHSVRSMMDNDKSYENHIDCHQQAVIKVKEEFTDPAYDMFYMSHYGLYNGNSASMAAL 731

  Fly   386 STAAASSASSSSASASANPPQTSIKMDL--DPDSDSAYMTSR 425
            ..:.|||.:..|      ||:.|.:.||  .||....|:..:
Frog   732 HESLASSLNYGS------PPKFSPEGDLCSSPDPKICYVCKK 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disco	NP_001033847.1	None
bnc2	XP_002935715.2	C2H2 Zn finger	366..387	CDD:275368	13/20 (65%)
		C2H2 Zn finger	394..412	CDD:275368	15/17 (88%)
		C2H2 Zn finger	762..783	CDD:275368	1/6 (17%)
		C2H2 Zn finger	790..808	CDD:275368
		C2H2 Zn finger	960..981	CDD:275368
		C2H2 Zn finger	988..1006	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59377at33208
OrthoFinder	1	1.000	-	-		FOG0002551
OrthoInspector	1	1.000	-	-		mtm9561
Panther	1	1.100	-	-	O	PTHR15021
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3798
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.140