DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment disco and bnc1

DIOPT Version :9

Sequence 1:	NP_001033847.1	Gene:	disco / 32579	FlyBaseID:	FBgn0000459	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	XP_004912674.2	Gene:	bnc1 / 100492394	XenbaseID:	XB-GENE-1217655	Length:	992	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	124/510 - (24%)
Similarity:	181/510 - (35%)	Gaps:	155/510 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FMSPAYLLGHGPHSHQHVHSHL------PSHPQPNAASPASSPGGSSGSGSGSAAGSGTGSGSSL 66
            |:..::|.......|....|::      |.....:..|.|||...:|.....|.:..|..
Frog   275 FLDSSFLTSSSATFHLENDSNMSTQDGAPKIEDDSPLSDASSHNNTSNYDISSVSPEGKN----- 334

  Fly    67 KPRRWGSPPINLAGQFINPATGKKRVQCSICFKTFCDKGALKIHFSAVHLREMHKCTVEGCNMVF 131
            ||..     .|:.|    |..|  ||.|:.|.|||.|||.||||::||||:..|:||:|||||||
Frog   335 KPTE-----RNING----PRKG--RVFCTACEKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMVF 388

  Fly   132 SSRRSRNRHSANPNPKLHSPHIRRK----------IS---------------------------- 158
            ||.|||||||:||||:||.|..|..          ||
Frog   389 SSLRSRNRHSSNPNPRLHMPMNRNNRDKDLRNGLIISVSEDSKRLASKSCNLDSRPGNNYVSTTS 453

  Fly   159 --------PHDGRTAQQFPVF-----------SPGTAAAAAAVAGRLPVAFPGLLPPPPPHHGHH 204
                    |:.|::...||..           ||.|.|..|..        ||:||..|
Frog   454 DTKLQSGLPNVGQSCVLFPNLKTVQPVLPFYRSPATPAELANT--------PGMLPSLP------ 504

  Fly   205 PYVMFGGQAGLHGLGLLSTGCQD------------PDSGSVDNEQDADPEDDNDFVYVDM-QANS 256
                           ::|:...:            |...|..:......:.::    :|. |.|.
Frog   505 ---------------VISSSISEKILSGDFLSDMMPKKKSRKSSMPIKIQKES----IDKPQGNL 550

  Fly   257 SSPAASSEDQEEHERDNEQDEEMHCSLSLASSSSIAADEERAADQPLDFSLHKRRKSEQDREQEQ 321
            ..| :|.||...||..:|..|....:.....|..|..|.       :....:|...|| |...:.
Frog   551 EEP-SSEEDNPIHEMSDETFENCDKNQDQKISGGIQRDN-------MSLDSYKLNDSE-DLHYQS 606

  Fly   322 EQEQEREREAEKEQEQDVESDKEHEPEQEHEL----EREKRSPSDAFSMDQLLGK-----RKRHD 377
            ..:.....|:...:.:...|:||:...|::.|    ...|...|:.|::.:.|.:     :::..
Frog   607 VMDNSYNSESSDSENEFQPSEKENNHIQDYPLNMNSSEHKIKHSNHFNVAKQLAEPNLFNKEQPK 671

  Fly   378 STASSSACSTAAASSASSSSASASANPPQTSIKMDLDPDSDSAYMTSRRQMLPLP 432
            .|.|..........:.|.|....|:.|.:||   |:|         |..|.|.:|
Frog   672 HTDSEGGGGGGEFQNYSMSMGLYSSIPNKTS---DID---------SGEQHLQIP 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
disco	NP_001033847.1	None
bnc1	XP_004912674.2	C2H2 Zn finger	351..372	CDD:275368	13/20 (65%)
		C2H2 Zn finger	379..397	CDD:275368	15/17 (88%)
		C2H2 Zn finger	722..743	CDD:275368
		C2H2 Zn finger	750..778	CDD:275368
		C2H2 Zn finger	928..949	CDD:275370
		C2H2 Zn finger	956..974	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D59377at33208
OrthoFinder	1	1.000	-	-		FOG0002551
OrthoInspector	1	1.000	-	-		mtm9561
Panther	1	1.100	-	-	O	PTHR15021
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3798
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.140