DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8958 and CG14693

DIOPT Version :9

Sequence 1:	NP_573105.1	Gene:	CG8958 / 32575	FlyBaseID:	FBgn0030725	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001262467.1	Gene:	CG14693 / 41299	FlyBaseID:	FBgn0037837	Length:	586	Species:	Drosophila melanogaster

Alignment Length:	628	Identity:	254/628 - (40%)
Similarity:	365/628 - (58%)	Gaps:	58/628 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KRNRDADIVKHKLDLRVRFKKLVRAVIMNQTWLSDEEEQGISMNVKKNV-ALMRQKRKPGMLTVA 67
            :|.::....|....|:..|||:||.:.:|..|..:|::..|:.||.||: |.:|.|.|.|.||.|
  Fly     3 RRTKNTADTKRIQSLKALFKKVVRLMSLNDPWRENEDDPRITSNVMKNLSARVRTKSKSGFLTAA 67

  Fly    68 DKALLRSNPAYRTIEERKKLCILIAGLNCFSRIPPKIRARMVPVLKFMSINEPRVIIKNGDMPIS 132
            ||:|:|:....|||.||.|||.|.|.|.|.:...||||||:|||::.|.::..|:||:..|.||:
  Fly    68 DKSLIRTPHVIRTIPERMKLCKLFAKLTCLAGFSPKIRARLVPVVRLMPVDAGRIIIRQSDAPIT 132

  Fly   133 VYFILNGEVEMKKNTNNKAVKLEDAVAEAIFGPGDCFGDVEMVEECPRMNTYLALSSCEVLSIYD 197
            |:|:|.|||.|.||..|:.   .:.|.....|.||..||||::|...|.:|:.|.:.||:|.::|
  Fly   133 VFFVLTGEVHMIKNEKNQK---GEGVVMGFLGAGDMMGDVELLEGIKRTHTFRAATYCELLVLFD 194

  Fly   198 IDYERILKPHMLKQWNEKKLALKAFDYFDFLTPDQIILACKYSYLVQYEPLETIYMGDTDSLGYV 262
            .|:..||..:|.|.|.|||.||||.||||||..|||:.||:|..|.|::||:||:..|..|:..|
  Fly   195 YDFAPILGAYMTKIWEEKKRALKALDYFDFLDDDQIVEACRYGRLKQFDPLDTIFCEDIGSMTNV 259

  Fly   263 RFVLSGECVILQCLSMKVTNTEGEVNYELTEINKDDGLEMFQ-------SWKDVTSRNSFLDIQD 320
            .|||||||:|||||::|||...|:..|:|...::.|..:||:       |.:......|.:||.|
  Fly   260 HFVLSGECLILQCLNIKVTMKRGKKVYDLLPASEGDVSKMFRKAVRSTFSSQSTNEDQSKIDILD 324

  Fly   321 ILASSTSSEEVEGGTKKKQA----MRKMGLAEIQKFCGLRTSNTPSRKKTKPRRTLSTAAQARKT 381
            ::||::||..   |..:|.|    ||||.|.:|:|.||: ..:.|.:.:...||
  Fly   325 LVASTSSSST---GDAQKSALNRKMRKMDLRDIEKRCGM-IKSPPQKSRFTWRR----------- 374

  Fly   382 QLIQSLRRGTPWMPSVMPNDDDDDDDDDDGHIDEDYMGYGEDLYDEVDTDDSSYDSNSSSSSVSM 446
                |:|:.|   .||..:.::....:|   :.||:.    ::| |.::|..||.|.|..:.|..
  Fly   375 ----SIRKST---MSVFSHSENRLISED---VFEDFW----EMY-ENESDIESYSSGSDYTDVEF 424

  Fly   447 DRTLVQVQLKPHSAGSSPSEKKVSSSSSEIFTASSVINEKSLVDESPKPIKEPVETHFIDVGSLT 511
            .::........::|........:.|||...|::||         .|..|   ..|:||||||::|
  Fly   425 KQSFRFGPALNNTAELDYDGSSIFSSSLSSFSSSS---------GSCTP---TFESHFIDVGTIT 477

  Fly   512 YGSVFGLGEKMEHRVIMARTVVQCLLLPRFWLLEEEQNPGNIWHRRRFYFECNVPSRQDLFTNFL 576
            :|.:||||||||:||||||:.||||:||||:|||::|||||:|.||..|....||||:.||.::.
  Fly   478 FGGIFGLGEKMENRVIMARSTVQCLILPRFFLLEKKQNPGNVWERRLLYVGVMVPSREALFAHYR 542

  Fly   577 KTRQWNKFRHDYIESLLDREEKGNITKEEDIPIMCRIVETSDD 619
            |...|.||::|.|...| :....:||..||:||:|||||:.:|
  Fly   543 KACDWKKFKNDLISETL-KPSDNDITHIEDVPIICRIVESPED 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8958	NP_573105.1	Crp	97..>212	CDD:223736	47/114 (41%)
CG8958	NP_573105.1	CAP_ED	97..207	CDD:237999	45/109 (41%)
CG14693	NP_001262467.1	Crp	90..>204	CDD:223736	49/116 (42%)
CG14693	NP_001262467.1	CAP_ED	97..204	CDD:237999	45/109 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448988
Domainoid	1	1.000	42	1.000	Domainoid score	I4774
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I6103
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253607at2759
OrthoFinder	1	1.000	-	-		FOG0012698
OrthoInspector	1	1.000	-	-		otm44319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11773
	9	9.000