Protein Alignment Tob and Tob1

DIOPT Version :10

• Sequence 1: NP_573104.1
• Gene: Tob / 32574
• FlyBaseID: FBgn0028397
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_033453.2
• Gene: Tob1 / 22057
• MGIID: 1349721
• Length: 362
• Species: Mus musculus
• Alignment Length: 470
• Identity: 165/470 - (35%)
• Similarity: 216/470 - (45%)
• Gaps: 161/470 - (34%)

  Fly     1 MHIEIQVALNFVISYLYNKLPRRRVNIFGEELEKALRDKFQDHWYPEKPFKGSAYRCLKTGDPID 65
            |.:||||||||:|||||||||||||||||||||:.|:.|::.|||||||:|||.:||:..|:.:|
Mouse     1 MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHVGEKVD 65

  Fly    66 SVLERAARESGVPIGDILENLPNELSVWIDPGEVSFRIGEKGAVKILYTENNENHEDSHSADREV 130
            .|:|:|::|||:.|.|:..|||.:|||||||.|||::|||||.||:||.:  ::.|.....|:|:
Mouse    66 PVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVD--DSSETGCELDKEI 128

  Fly   131 TKMFNPEAQCFRPIDAVNTTMNNMSLSPKGHHQSGSSPHSAASSSPTYKGSPNRTISGSCSSVSG 195
            ...||||||.|.||                     |.|.|:.||||:
Mouse   129 KNSFNPEAQVFMPI---------------------SDPASSVSSSPS------------------ 154

  Fly   196 AGSGTGSGSRSGSNHAPGPGTAPGPVPGNGATANAAAAAFMQRGAQAPLTFTTATFAQTKFGSTK 260
                                    |..|:.|   |.:..||.|..| ||||||||||.|||||||
Mouse   155 ------------------------PPFGHSA---AVSPTFMPRSTQ-PLTFTTATFAATKFGSTK 191

  Fly   261 LKTSSKRTNSSSAYRMSP------TEFSNYIKQRAMQQQMHHGHAVVPSAGSSVSAAYG-GMDA- 317
            :|.|.:   ||...|.||      ...::.:||:|:              .|||.:.|| |:.:
Mouse   192 MKNSGR---SSKVARTSPINLGLTVNVNDLLKQKAI--------------SSSVHSLYGLGLGSQ 239

  Fly   318 ------------VSPARSLSPNPL--------SLAGNQNQSVSGSS--ADSYYYPNM-------- 352
                        ..|:.|..|.||        .....|.|..|..|  |..:.:|||
Mouse   240 QQPQPQPQQQQQQQPSSSQPPPPLPQQQQQQPQQQQQQQQQTSALSPNAKEFIFPNMQGQGSSTN 304

  Fly   353 -------PINMYP-QYGNPRCLFESHFSADVSSMGLYVSGTAGAAVTAVGSVGANKYSTYLEPCY 409
                   |:|:.| ||.|...:|.::...:..|   :|.|.
Mouse   305 GMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKS---FVDGL------------------------ 342

  Fly   410 YGNGHANTQQHSQQQ 424
              |...|..|:|.||
Mouse   343 --NFSLNNMQYSNQQ 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tob	NP_573104.1	BTG	1..113	CDD:462251	74/111 (67%)
Tob1	NP_033453.2	btg1	1..106	CDD:128410	69/104 (66%)
		Bipartite nuclear localization signal	22..39		13/16 (81%)
		Important for nuclear localization	82..92		4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..171		12/71 (17%)
		Required for interaction with CPEB3. /evidence=ECO:0000250|UniProtKB:P50616	161..220		30/65 (46%)
		Nuclear export signal	228..236		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..284		9/49 (18%)