DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tob and TOB2

DIOPT Version :9

Sequence 1:	NP_001162772.1	Gene:	Tob / 32574	FlyBaseID:	FBgn0028397	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_057356.1	Gene:	TOB2 / 10766	HGNCID:	11980	Length:	344	Species:	Homo sapiens

Alignment Length:	442	Identity:	149/442 - (33%)
Similarity:	208/442 - (47%)	Gaps:	124/442 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIEIQVALNFVISYLYNKLPRRRVNIFGEELEKALRDKFQDHWYPEKPFKGSAYRCLKTGDPID 65
            |.:||:|||||:||||||||||||.::||||||:.|:.|::.|||||||.|||.:||:..|:.:|
Human     1 MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHIGEMVD 65

  Fly    66 SVLERAARESGVPIGDILENLPNELSVWIDPGEVSFRIGEKGAVKILYTENNENHEDSHSADREV 130
            .|:|.||:.||:.:.|:..|:|.||||||||.|||::||||||||:||.:::|.. .:...|:|:
Human    66 PVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVLYLDDSEGC-GAPELDKEI 129

  Fly   131 TKMFNPEAQCFRPIDAVNTTMNNMSLSPKGHHQSGSSPHSAASSSPTYKGSPNRTISGSCSSVSG 195
            ...|||:||.|.||.:.:::::|                   |.||::..||:.|
Human   130 KSSFNPDAQVFVPIGSQDSSLSN-------------------SPSPSFGQSPSPT---------- 165

  Fly   196 AGSGTGSGSRSGSNHAPGPGTAPGPVPGNGATANAAAAAFMQRGAQAPLTFTTATFAQTKFGSTK 260
                                                   |:.|.|| |:|||||:||.|||||||
Human   166 ---------------------------------------FIPRSAQ-PITFTTASFAATKFGSTK 190

  Fly   261 LKTSSKRTNSSSAYRMSPTEFSNYIKQRAMQQQMHHGHAVVPSAGSSVSAAYGGMD-------AV 318
            :|..                                |.|.  |.|...|:..||..       |.
Human   191 MKKG--------------------------------GGAA--SGGGVASSGAGGQQPPQQPRMAR 221

  Fly   319 SPARS-LSPNPLSLAGNQNQSVSGSSA-DSYYYPNMPINMYPQYGNPRCLFESHFSADVSSMGLY 381
            ||..| |....|||:.:....::.:.| .|...||....:|...|:|...|::.......:.|.:
Human   222 SPTNSLLKHKSLSLSMHSLNFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPF 286

  Fly   382 VSGTAGAA------VTAVGSVGANKYSTYLEPCYYGNG---HANTQQHSQQQ 424
            ....||..      :..|...|||  |.:||...:..|   :.||.|:..||
Human   287 GGSGAGTCNSSSFDMAQVFGGGAN--SLFLEKTPFVEGLSYNLNTMQYPSQQ 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tob	NP_001162772.1	BTG	1..112	CDD:285041	70/110 (64%)
TOB2	NP_057356.1	BTG	1..111	CDD:369496	69/109 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..169		8/92 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..225		11/67 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147751
Domainoid	1	1.000	168	1.000	Domainoid score	I3838
eggNOG	1	0.900	-	-		E1_KOG4006
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000571
OrthoInspector	1	1.000	-	-		otm41494
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR17537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5717
SonicParanoid	1	1.000	-	-		X3071
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830