DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tob and TOB1

DIOPT Version :9

Sequence 1:	NP_001162772.1	Gene:	Tob / 32574	FlyBaseID:	FBgn0028397	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001230806.1	Gene:	TOB1 / 10140	HGNCID:	11979	Length:	345	Species:	Homo sapiens

Alignment Length:	444	Identity:	160/444 - (36%)
Similarity:	212/444 - (47%)	Gaps:	126/444 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHIEIQVALNFVISYLYNKLPRRRVNIFGEELEKALRDKFQDHWYPEKPFKGSAYRCLKTGDPID 65
            |.:||||||||:|||||||||||||||||||||:.|:.|::.|||||||:|||.:||:..|:.:|
Human     1 MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVD 65

  Fly    66 SVLERAARESGVPIGDILENLPNELSVWIDPGEVSFRIGEKGAVKILYTENNENHEDSHSADREV 130
            .|:|:|::|||:.|.|:..|||.:|||||||.|||::|||||.||:||.:  :|:|:....|:|:
Human    66 PVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVD--DNNENGCELDKEI 128

  Fly   131 TKMFNPEAQCFRPIDAVNTTMNNMSLSPKGHHQSGSSPHSAASSSPTYKGSPNRTISGSCSSVSG 195
            ...||||||.|.||                     |.|.|:.||||:
Human   129 KNSFNPEAQVFMPI---------------------SDPASSVSSSPS------------------ 154

  Fly   196 AGSGTGSGSRSGSNHAPGPGTAPGPVPGNGATANAAAAAFMQRGAQAPLTFTTATFAQTKFGSTK 260
                                    |..|:.|   |.:..||.|..| ||||||||||.|||||||
Human   155 ------------------------PPFGHSA---AVSPTFMPRSTQ-PLTFTTATFAATKFGSTK 191

  Fly   261 LKTSSKRTNSSSAYRMSPTEF----SNYIKQRAMQQQMHHGHAVVPSAGSSVSAAYGGMDAVSPA 321
            :|.|.:   |:...|.||...    ::.:||:|:...||..:.:  ..||..........|..|.
Human   192 MKNSGR---SNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGL--GLGSQQQPQQQQQPAQPPP 251

  Fly   322 RSLSPNPLSLAGNQNQSVSGSSADSYYYPNM---------------PINMYP-QYGNPRCLFESH 370
               .|.|......|..|....:|..:.:|||               |:|:.| ||.|...:|.::
Human   252 ---PPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAY 313

  Fly   371 FSADVSSMGLYVSGTAGAAVTAVGSVGANKYSTYLEPCYYGNGHANTQQHSQQQ 424
            ...:..|   :|.|.                          |...|..|:|.||
Human   314 GGLNEKS---FVDGL--------------------------NFSLNNMQYSNQQ 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tob	NP_001162772.1	BTG	1..112	CDD:285041	74/110 (67%)
TOB1	NP_001230806.1	btg1	1..106	CDD:128410	69/104 (66%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	22..39		13/16 (81%)
		Important for nuclear localization. /evidence=ECO:0000250	82..92		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..171		12/71 (17%)
		Required for interaction with CPEB3. /evidence=ECO:0000269\|PubMed:21336257	161..218		29/63 (46%)
		Nuclear export signal. /evidence=ECO:0000250	226..234		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..267		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147750
Domainoid	1	1.000	168	1.000	Domainoid score	I3838
eggNOG	1	0.900	-	-		E1_KOG4006
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000571
OrthoInspector	1	1.000	-	-		otm41494
orthoMCL	1	0.900	-	-		OOG6_110727
Panther	1	1.100	-	-	O	PTHR17537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5717
SonicParanoid	1	1.000	-	-		X3071
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.730