DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nipsnap and NIPSNAP1

DIOPT Version :9

Sequence 1:	NP_001285316.1	Gene:	Nipsnap / 32573	FlyBaseID:	FBgn0030724	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_003625.2	Gene:	NIPSNAP1 / 8508	HGNCID:	7827	Length:	284	Species:	Homo sapiens

Alignment Length:	253	Identity:	124/253 - (49%)
Similarity:	163/253 - (64%)	Gaps:	9/253 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SRNDSESWFSKLLVRKIEPTKESHSRMLSDKEI--IYALHTHNVRPDSMGSYLNNYKTTVALINE 88
            |:::..|||..|.|.|::|.|::||.:||.||.  :|.:..|||:|:    ||:.|.:....:..
Human    36 SKDNEGSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPE----YLDAYNSLTEAVLP 96

  Fly    89 K---KANLSCELVASWTVQVGDMDQCLHLWKYTGGFEKIDQAKEDLWNDPEYLSLMQERSKFLRS 150
            |   ..:..|.||.:|....|:.||.:|||:::||:..:......|.|:.|||...:|||:.|.|
Human    97 KLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLS 161

  Fly   151 RHLQYLLAFSYWPQIASRTGKNIYEMRSYRLTPGTMIEWGNNWARAINYRKHNNEAFAGFFSQIG 215
            |..|.||.||:|.:...|.|.||||:|:|:|.|||||||||||||||.||:.|.||..|||||||
Human   162 RRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIG 226

  Fly   216 RLYNVHHIWCYKSLQDRKETREAAWRSPGWDECVAYTVPLIREMHCRVLAPTEFSPSQ 273
            .||.|||:|.||.||.|:|||.||||..||||.|.|||||:|.|..|::.|.:.||.|
Human   227 ELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipsnap	NP_001285316.1	NIPSNAP	174..271	CDD:285252	64/96 (67%)
NIPSNAP1	NP_003625.2	NIPSNAP	185..282	CDD:285252	64/96 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148021
Domainoid	1	1.000	152	1.000	Domainoid score	I4321
eggNOG	1	0.900	-	-		E1_KOG2883
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3107
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52951
OrthoDB	1	1.010	-	-		D1141024at2759
OrthoFinder	1	1.000	-	-		FOG0003040
OrthoInspector	1	1.000	-	-		otm42001
orthoMCL	1	0.900	-	-		OOG6_103770
Panther	1	1.100	-	-	LDO	PTHR21017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R944
SonicParanoid	1	1.000	-	-		X1761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800