DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nipsnap and NIPSNAP2

DIOPT Version :9

Sequence 1:	NP_001285316.1	Gene:	Nipsnap / 32573	FlyBaseID:	FBgn0030724	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_001474.1	Gene:	NIPSNAP2 / 2631	HGNCID:	4179	Length:	286	Species:	Homo sapiens

Alignment Length:	258	Identity:	118/258 - (45%)
Similarity:	168/258 - (65%)	Gaps:	3/258 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VRSLSTTPSRNDSESWFSKLLVRKIEPTKESHSRMLSDKEI--IYALHTHNVRPDSMGSYLNNYK 80
            :|:.:::.:|:..:||...|.|||::|.|::||.:|:.||.  :|.|..|||:|:.:.:|....:
Human    30 LRTWTSSSNRSREDSWLKSLFVRKVDPRKDAHSNLLAKKETSNLYKLQFHNVKPECLEAYNKICQ 94

  Fly    81 TTVALINEKKANLSCELVASWTVQVGDMDQCLHLWKYTGGFEKIDQAKEDLWNDPEYLSLMQERS 145
            ..:..|:|.| :..|.||.:|....|:.||.:|||:|.||:..:.:....|..:.|:|...:.||
Human    95 EVLPKIHEDK-HYPCTLVGTWNTWYGEQDQAVHLWRYEGGYPALTEVMNKLRENKEFLEFRKARS 158

  Fly   146 KFLRSRHLQYLLAFSYWPQIASRTGKNIYEMRSYRLTPGTMIEWGNNWARAINYRKHNNEAFAGF 210
            ..|.||..|.||.||:|.:...|:|.||||:|||:|.|||||||||.|||||.:|:..|||..||
Human   159 DMLLSRKNQLLLEFSFWNEPVPRSGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDGNEAVGGF 223

  Fly   211 FSQIGRLYNVHHIWCYKSLQDRKETREAAWRSPGWDECVAYTVPLIREMHCRVLAPTEFSPSQ 273
            |||||:||.|||:|.|:.||.|::.|.|||...||:|.|.||||||:||..|::.|.:.||.|
Human   224 FSQIGQLYMVHHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipsnap	NP_001285316.1	NIPSNAP	174..271	CDD:285252	59/96 (61%)
NIPSNAP2	NP_001474.1	NIPSNAP	187..284	CDD:311781	59/96 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148019
Domainoid	1	1.000	152	1.000	Domainoid score	I4321
eggNOG	1	0.900	-	-		E1_KOG2883
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1137
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3107
Isobase	1	0.950	-	0	Normalized mean entropy	S3667
OMA	1	1.010	-	-		QHG52951
OrthoDB	1	1.010	-	-		D1141024at2759
OrthoFinder	1	1.000	-	-		FOG0003040
OrthoInspector	1	1.000	-	-		otm42001
orthoMCL	1	0.900	-	-		OOG6_103770
Panther	1	1.100	-	-	O	PTHR21017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R944
SonicParanoid	1	1.000	-	-		X1761
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750