DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nipsnap and Nipsnap2

DIOPT Version :9

Sequence 1:	NP_001285316.1	Gene:	Nipsnap / 32573	FlyBaseID:	FBgn0030724	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_032121.3	Gene:	Nipsnap2 / 14467	MGIID:	1278343	Length:	281	Species:	Mus musculus

Alignment Length:	258	Identity:	118/258 - (45%)
Similarity:	167/258 - (64%)	Gaps:	3/258 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VRSLSTTPSRNDSESWFSKLLVRKIEPTKESHSRMLSDKEI--IYALHTHNVRPDSMGSYLNNYK 80
            :|:::::..|...:||...|.|||::|.|::||.:|:.||.  :|.|..|||:|:.:.:|....:
Mouse    25 LRTVTSSSHRAREDSWLKSLFVRKVDPRKDAHSNLLAKKETSSLYKLQFHNVKPECLDAYNKICQ 89

  Fly    81 TTVALINEKKANLSCELVASWTVQVGDMDQCLHLWKYTGGFEKIDQAKEDLWNDPEYLSLMQERS 145
            ..:..|:|.| ...|.||.:|....|:.||.:|||:|.||:..:.:....|..:.|:::..:.||
Mouse    90 EVLPKIHEGK-QYPCTLVGTWNTWYGEQDQAVHLWRYEGGYPALTEVMNKLKENQEFVNFRKARS 153

  Fly   146 KFLRSRHLQYLLAFSYWPQIASRTGKNIYEMRSYRLTPGTMIEWGNNWARAINYRKHNNEAFAGF 210
            ..|.||..|.||.||:|.:...|.|.||||:|||:|.|||||||||.|||||.:|:.:|||..||
Mouse   154 DMLLSRKNQLLLEFSFWNEPVPRPGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDSNEAVGGF 218

  Fly   211 FSQIGRLYNVHHIWCYKSLQDRKETREAAWRSPGWDECVAYTVPLIREMHCRVLAPTEFSPSQ 273
            |||||:||.|||:|.||.||.|::.|.|||...||:|.|.||||||:||..|::.|.:.||.|
Mouse   219 FSQIGQLYMVHHLWAYKDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nipsnap	NP_001285316.1	NIPSNAP	174..271	CDD:285252	60/96 (63%)
Nipsnap2	NP_032121.3	NIPSNAP	182..279	CDD:285252	60/96 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838114
Domainoid	1	1.000	152	1.000	Domainoid score	I4310
eggNOG	1	0.900	-	-		E1_KOG2883
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1137
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3069
Isobase	1	0.950	-	0	Normalized mean entropy	S3667
OMA	1	1.010	-	-		QHG52951
OrthoDB	1	1.010	-	-		D1141024at2759
OrthoFinder	1	1.000	-	-		FOG0003040
OrthoInspector	1	1.000	-	-		otm44053
orthoMCL	1	0.900	-	-		OOG6_103770
Panther	1	1.100	-	-	O	PTHR21017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R944
SonicParanoid	1	1.000	-	-		X1761
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750