DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr18 and ush2a

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	530	Identity:	102/530 - (19%)
Similarity:	164/530 - (30%)	Gaps:	220/530 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SVETKSPSASEQSR----NGENRSLLFDDYNKTKSTLSTADYLSATRATLYAFSSQDQDEDHSQM 113
            |.||...|....||    ||.:..:.:::..:.:..:..           |...:..:|.. |..
Zfish  1971 SRETVPQSVLPPSRVGSVNGSSVEVSWEEPAEVRGVIEK-----------YVLKAYSRDRP-SSS 2023

  Fly   114 PIEASNAPHSPIPTKMSRGKIPMETPGSMEFSSNSLPIKNVGTTDQLTTVTMPTTAFASLKVDRS 178
            ||.|: .|||...|....|..|        |||.|:            |:|..|.|..|
Zfish  2024 PISAT-FPHSQHLTGTLSGLAP--------FSSYSI------------TLTACTQAGCS------ 2061

  Fly   179 TMKQPIDSTRTRNHWTASGFARVTERPRSKHHHEHHWGPFFEEPINSATSGDNLVSAVH------ 237
              :.|.          |:||....|.|.             |.|..:|.|..|.:| ||
Zfish  2062 --ESPF----------ATGFNTPQEAPE-------------EVPPPAAVSYPNSLS-VHWNHPPK 2100

  Fly   238 ---LFTEAVLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLINPT 299
               :..:.:|      .|:.||:: |..:...::..||..|             |:  :||:  :
Zfish  2101 PNGIIIQYIL------YKNNTVLY-RGNSTSFNITDVGVFT-------------PH--KLLL--S 2141

  Fly   300 QTEDAGVYMCQVSTHPPRVFTTNL--TVLEPP-LRIIDE----------------------HERD 339
            ...:||   |..||. ..:||..|  |.:||| |.::|.                      |:..
Zfish  2142 ACTEAG---CTNSTQ-VTLFTGQLPPTYVEPPILTVLDARSIHIQWAAPVEVNGLLEFYTLHQWA 2202

  Fly   340 VGDR---YYKS--------------GSTVDLQ--------CQISRSFFQKERQTILKSTDSANDA 379
            :|:.   .|.|              |||...|        |.:|               |.:...
Zfish  2203 LGEEPLIVYNSSELFQDYTVRNLVPGSTYLFQIAACTGGGCTLS---------------DPSTAR 2252

  Fly   380 VQKLINETTSELNLIGNVNQTQHKFSGQDLEKYFTKFITWAKDEEP----------LQG--MTNR 432
            .::...|.....|::.....:.|              ::|....:|          :.|  :.|.
Zfish  2253 TEESSPEEVPAPNILSLSPHSLH--------------LSWTPPRKPNGVISSYGLWMDGTLVQNS 2303

  Fly   433 RLSVSDVWLTSRISIGDAKLSDSGNYSCSLGRLFTVIVQVQVLTGELPAAVQHNIGSRTEIYSLA 497
            .|..|:|...|..|:...::.......|:||.|      |:..|.|:|.
Zfish  2304 SLMASEVGDLSPWSLHSFRVQACTAQGCALGPL------VESRTLEMPP---------------- 2346

  Fly   498 MLGHLLVLIF 507
             :||:.:::|
Zfish  2347 -VGHVTLVVF 2355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	19/84 (23%)
		Ig	<258..326	CDD:299845	16/69 (23%)
		IGc2	<417..461	CDD:197706	9/55 (16%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020	29/140 (21%)
		FN3	2163..2253	CDD:238020	17/104 (16%)
		FN3	2258..2341	CDD:238020	17/102 (17%)
		FN3	2352..2443	CDD:238020	1/4 (25%)
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900