DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr18 and igsf9a

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_005155702.1	Gene:	igsf9a / 557459	ZFINID:	ZDB-GENE-060503-288	Length:	1619	Species:	Danio rerio

Alignment Length:	470	Identity:	97/470 - (20%)
Similarity:	148/470 - (31%)	Gaps:	158/470 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 TTVTMPTTAFASLKVDRSTMKQPIDSTRTRNHWTASGFARVTERPRSKHHHEHHWGPFFEEPINS 225
            ::..:|.:..|..| |.|..:..|:       |...||..........|...|   |.::..: |
Zfish    35 SSAVLPCSLPAPQK-DSSASQYVIE-------WVRQGFDTPIFMQLGVHPRVH---PDYDGRV-S 87

  Fly   226 ATSGDNL-VSAVHLFTEAVLNCRVGMLKDKTV-------MWVRRTAEKVSLLT----------VG 272
            ...|.:| :|.:.|..|....||:..| |:|.       .|.|.:.....:||          ||
Zfish    88 LFGGTSLQMSGLQLEDEGWYECRILPL-DQTTEEAGSSGSWTRLSVTAPPVLTETSPPEVEVFVG 151

  Fly   273 ---------------NVTYSGD-----PRIRVKFQYPNNWRLLINPTQTEDAGVYMCQVS----- 312
                           .:|:|.|     |:.:||..   |..:..:....|.||.|.|..|
Zfish   152 RSLTLKCAAQGNPRPTITWSKDGAPIKPQHKVKMV---NGSVSFHAVSREAAGQYQCYTSNSEGN 213

  Fly   313 -THPPRVFTTNLTVLEPPLRIIDEHERDVGDRYYKSGSTVDLQCQIS----RSFFQKERQTI-LK 371
             ||     .|.|.::.||:.||..     .|..........|:||..    ...:..:||.: :.
Zfish   214 ATH-----VTRLKIIGPPVIIIPP-----SDTVLNMSQDAKLKCQAEADPPNMTYVWQRQGVDIY 268

  Fly   372 STDSANDAVQKLINETTSELNLI----GN-----------------VNQTQHKFSGQDLEKYF-- 413
            ..||....::.:::.|.....|.    ||                 |...||......:.|..
Zfish   269 HIDSLKSRIKVIVDGTLLISRLAPEDSGNYTCMPTNGLPVSPSASAVLTVQHPAQVIQMPKLTFL 333

  Fly   414 -----------------TKFITWAKDEEPLQGMTNRRLSVSDVW-LTSRISIGDAKLSD--SGNY 458
                             ...|.|.||.:||.      |.:...| |.|..||..|.::|  :|.|
Zfish   334 PTGMRGAIVCPVRAEPPLSHIDWIKDGKPLD------LGMYPGWTLASDGSIVIATVNDDAAGVY 392

  Fly   459 SCSLGRLF---------TVIVQ------------------------VQVLTGELPAAVQHNIGSR 490
            .|:....|         |||:|                        .|::....|......||:.
Zfish   393 ICTPYNSFGTTGQSEPTTVILQDPPSFKVSPRNEYRQDVGTMLVIPCQMVGNPAPKVNWRKIGAA 457

  Fly   491 T-EIYSLAMLGHLLV 504
            | .:::||..|.|::
Zfish   458 TRSLFTLAGNGSLIL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	28/125 (22%)
		Ig	<258..326	CDD:299845	23/103 (22%)
		IGc2	<417..461	CDD:197706	16/46 (35%)
igsf9a	XP_005155702.1	IG_like	27..110	CDD:214653	18/86 (21%)
		Ig	35..111	CDD:299845	19/87 (22%)
		I-set	140..221	CDD:254352	18/88 (20%)
		IGc2	151..212	CDD:197706	14/63 (22%)
		Ig	233..318	CDD:299845	13/84 (15%)
		I-set	233..318	CDD:254352	13/84 (15%)
		Ig	<349..402	CDD:299845	18/58 (31%)
		IG_like	423..502	CDD:214653	9/50 (18%)
		Ig	435..498	CDD:143165	9/38 (24%)
		FN3	507..602	CDD:238020
		fn3	614..696	CDD:278470
		PHA02666	1105..>1312	CDD:222914
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900