DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and lrit1a

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	469	Identity:	95/469 - (20%)
Similarity:	164/469 - (34%)	Gaps:	140/469 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IGSQVQVLYTTSVETKSPSASEQSRNGE--NRSLLFDDYNK--TKSTLS--------TADYLSAT 94
            :|:.| :|...:|....|..:.:..:|:  |.::|.::..:  ..|.||        |..|:  .
Zfish   265 VGNNV-LLRCGTVGVPIPELAWRRADGKPLNGTVLLENSKEGIVWSILSVPAVSYRDTGKYI--C 326

  Fly    95 RATLYAFSSQDQDEDHSQMPIEASNAPHSPIPTKMSRGKIPMETPGSMEFSSNSLPIKNVGTTDQ 159
            :||.||.|::      :.:.:..::||....||...:.|:..:.|.:|        :|.......
Zfish   327 KATNYAGSAE------AVISLIINDAPKMENPTLDPKPKLKSKKPNTM--------VKAAYQEKH 377

  Fly   160 LTTVTMPTTAFASLKVDRSTMKQPIDSTRTRNHWTASGFARVTERPRSKHHHEHHWGPF-FEEPI 223
            :.|...||                     .:|....||....|             ||: ..|..
Zfish   378 IATYVSPT---------------------PKNGLPLSGTVSYT-------------GPYPGMESD 408

  Fly   224 NSATSGDNLVSAVHLFTEAVLNCRVGMLKDKTVMWVRRTAEKV--SLLTVGNVTYSGDPRIRVKF 286
            |:|.|..|..:|   ..:..|...:..|...|.. :::..::|  |:..:|:..|:
Zfish   409 NAANSRMNTQTA---SPDGFLETNLSNLAANTSS-LQQDPDRVVRSVKVIGDTDYT--------- 460

  Fly   287 QYPNNWRLLINPTQTEDAGVYMCQVSTHPPRVFTTNLTVLEPPLRIIDEHERDV--------GDR 343
             ...|||.   ||...                 ||..:||....     .|||:        .:|
Zfish   461 -VCLNWRA---PTAKN-----------------TTAFSVLYAVF-----GERDMRRINVSPGNNR 499

  Fly   344 YYKSG---STVDLQCQISRSFFQKERQTILKSTDSANDA--VQKLINETTSELNLI--------- 394
            ....|   .|..:.|...:....|:.|.::.|||:|..|  .|||||.....:..:
Zfish   500 IVIEGLVPKTKYIACVCVKGLIPKKEQCVIFSTDAAASANGTQKLINVVVITVACVIAVPLTVIV 564

  Fly   395 --GNVNQTQHKFSG---QDLEKYFTKFITWAKDEEP--LQG--MTNRRLSVSDVWLTSRISI--- 447
              |.:.:...||.|   :|::..:..|.|.:...:.  |:|  :|......|:..|::|.|:
Zfish   565 CCGALKRKIKKFLGKNSKDIQDSYVTFETLSPSTKAKGLEGEYLTRLNAEESNRLLSARSSLDSE 629

  Fly   448 GDAKLSDSGN-YSC 460
            ..||:....| |.|
Zfish   630 STAKIEGQPNEYFC 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	14/84 (17%)
		Ig	<258..326	CDD:299845	11/69 (16%)
		IGc2	<417..461	CDD:197706	13/52 (25%)
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..119	CDD:290566
		LRR_RI	<77..175	CDD:238064
		leucine-rich repeat	85..108	CDD:275378
		LRR_8	108..167	CDD:290566
		leucine-rich repeat	109..132	CDD:275378
		leucine-rich repeat	133..156	CDD:275378
		leucine-rich repeat	157..170	CDD:275378
		LRRCT	199..243	CDD:214507
		I-set	252..343	CDD:254352	18/86 (21%)
		Ig	259..333	CDD:299845	16/70 (23%)
		fn3	448..515	CDD:278470	18/101 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900