DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	334	Identity:	67/334 - (20%)
Similarity:	112/334 - (33%)	Gaps:	127/334 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 LNCRVGMLKD-KTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLINPTQTEDAGVY 307
            |.||....|. .|::|.|...::...:....:...|.....|.       :||||||..:...|:
Human   141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVS-------QLLINPTDLDIGRVF 198

  Fly   308 MCQVST----------------HPPRVFTTNLTVLEPPLRIIDEHERDV------------GDRY 344
            .|:...                |||   |..|:: ||  :.:.|.||.|            |.|:
Human   199 TCRSMNEAIPSGKETSIELDVHHPP---TVTLSI-EP--QTVQEGERVVFTCQATANPEILGYRW 257

  Fly   345 YKSGSTVD------LQCQISRSFFQK----ERQTILKSTDSANDAVQKLIN------------ET 387
            .|.|..::      .:..:..|||.:    |....:.||:     |..|:|            .|
Human   258 AKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTN-----VSTLVNVHFAPRIVVDPKPT 317

  Fly   388 TSELN--------LIGNVNQTQHKFSGQDLEKYFTKFITWAKDEE----------PLQGMTNRRL 434
            |:::.        .:||...|                :||.|.:.          |...::.:.|
Human   318 TTDIGSDVTLTCVWVGNPPLT----------------LTWTKKDSNMGPRPPGSPPEAALSAQVL 366

  Fly   435 SVSDVWLTSRISIGDAKLSDSGNYSCSLGRLFTVIVQVQVLTGELP-----------AAVQHNI- 487
            |.|:..|...::..||     |.|:|.     .::.::.|...|:|           .|||:.:
Human   367 SNSNQLLLKSVTQADA-----GTYTCR-----AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR 421

  Fly   488 --GSRTEIY 494
              |.:.|.:
Human   422 GDGGKVECF 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	22/97 (23%)
		Ig	<258..326	CDD:299845	17/83 (20%)
		IGc2	<417..461	CDD:197706	12/53 (23%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352
		Ig	25..116	CDD:299845
		Ig2_KIRREL3-like	138..219	CDD:143236	17/84 (20%)
		I-set	223..304	CDD:254352	21/91 (23%)
		Ig_2	227..305	CDD:290606	20/85 (24%)
		Ig_2	311..405	CDD:290606	21/119 (18%)
		IG_like	314..405	CDD:214653	21/116 (18%)
		Ig5_KIRREL3	407..504	CDD:143306	5/24 (21%)
		IG_like	416..504	CDD:214653	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810