DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpr18 and SDK2

DIOPT Version :9

Sequence 1:NP_573102.1 Gene:dpr18 / 32572 FlyBaseID:FBgn0030723 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:322 Identity:74/322 - (22%)
Similarity:113/322 - (35%) Gaps:102/322 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 GPFFEEPINSATSGDNLVS-AVHLFTEAVLNCRVG----------MLKDKTVMWVRRTAEKVSLL 269
            |.::.:.:|. .:|||..| .:.|..|     .||          ::..|....|..|:| |:|.
Human   179 GRYYVQAVND-KNGDNKTSQPITLTVE-----NVGGPADPIAPTIIIPPKNTSVVAGTSE-VTLE 236

  Fly   270 TVGNVTYSGDPRIRVKFQY------------PNNWRLLI-NPTQTEDAGVYMCQV----STHPPR 317
            .|.|..    |.|::...:            .:|.||.| |||.: |||.|.|:.    |:.|..
Human   237 CVANAR----PLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGS-DAGYYECEAVLRSSSVPSV 296

  Fly   318 VFTTNLTVLEPPLRIIDEHERDVGDRYYKSGSTVDLQCQI------------SRSFFQKERQTIL 370
            |....|:||||| :.:.|.||.:.....|   .||:.||.            ..:..:.|:.|..
Human   297 VRGAYLSVLEPP-QFVKEPERHITAEMEK---VVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRF 357

  Fly   371 KSTDSANDAVQKLINETTSEL-----NLIGNVNQTQHKFSGQDLEKYFTK--------------- 415
            :..:.....:..|:.:.|...     |..|.| ||....:...:....|:               
Human   358 RQRNDGGLQISGLVPDDTGMFQCFARNAAGEV-QTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 421

  Fly   416 ----------FITWAKDEEPLQGMTNRRLSVSDVWL-------TSRISIGDAKLSDSGNYSC 460
                      .|||.|.|        |.|:...|.|       :..:.|....:||:|.|:|
Human   422 ACETSGAPRPAITWQKGE--------RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr18NP_573102.1 IG_like 242..325 CDD:214653 28/109 (26%)
Ig <258..326 CDD:299845 25/84 (30%)
IGc2 <417..461 CDD:197706 15/51 (29%)
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352 7/24 (29%)
Ig 132..210 CDD:299845 10/36 (28%)
IG_like 222..304 CDD:214653 26/87 (30%)
IGc2 233..286 CDD:197706 18/57 (32%)
I-set 308..397 CDD:254352 18/93 (19%)
Ig 326..394 CDD:143165 13/68 (19%)
I-set 402..492 CDD:254352 16/82 (20%)
Ig 416..492 CDD:299845 15/68 (22%)
Ig 502..586 CDD:299845
IG_like 502..586 CDD:214653
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.