DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr18 and tutl

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	116/590 - (19%)
Similarity:	199/590 - (33%)	Gaps:	168/590 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IGSQ--VQVLYTTSVETKSPSASEQSRNGE----NRSLLFDDYNK-TKSTLSTADYLSATRATLY 99
            :||.  .:.|.|.....||....:||:..|    ..|....|.:: |.:|:..:..|:|:.|...
  Fly     7 LGSHRWCRALSTQHNTEKSKEQQQQSQPLEIPEQRASKCRGDIDRTTTTTIPASKTLTASPAKTA 71

  Fly   100 AFSSQDQDEDHSQMPIEASNAPHSPIPTKMSRGKIPMETPGSMEFSSNSL--------------- 149
            ||:.:......|:...|.|:.   .:|.:..:|..|..|...::|...||
  Fly    72 AFTVKTTRRRRSRRRAEGSSI---CVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPE 133

  Fly   150 -------------------------PIKNVGTTDQLTTVT---MPTTAFASL-----------KV 175
                                     |:..|...|:..:.|   :|...:...           :|
  Fly   134 DAVHITAILGEGVIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRV 198

  Fly   176 DRSTMKQPIDS-----TRTRNH---WTASGFARVTERPRSKHHHEHHWGPFFE-----EPINSAT 227
            .|.:...|..|     |..|..   |.......:...|:     :|..|.:|.     .|..|.|
  Fly   199 SRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPK-----QHKNGTWFHLDVHAPPRFSVT 258

  Fly   228 SGDNLVSAVHLFTEAVLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNW 292
            ..|  :..|:|....:|||:........::|. :.|..|            ||...|.. :.:..
  Fly   259 PED--IIYVNLGDSIILNCQADGTPTPEILWY-KDANPV------------DPSPTVGI-FNDGT 307

  Fly   293 RLLINPTQTEDAGVYMC-------QVSTHPPRVF----------TTNLTVLEPPLRIIDEHER-- 338
            .|.|:..:.||.|.|.|       ||| |..||.          .||.|.||.. ::|...|.
  Fly   308 ELRISTIRHEDIGEYTCIARNGEGQVS-HTARVIIAGGAVIMVPPTNQTKLEGE-KVIFSCEAKA 370

  Fly   339 ---DVGDRYYKSGSTV-DLQCQISRSFFQKERQTI---LKSTDSA-------------NDAVQKL 383
               :|..|:|:.||.| ::....:|...:|:...|   :|..||.             ..|...|
  Fly   371 MPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYL 435

  Fly   384 INETTSELNLIGNVNQTQHKFSGQDLEKYF-----TKFITWAKDE---EPLQGMTNRRLSVSDVW 440
            ..|..:::.....|.....:.:|. ::.|.     .:::||.||:   ||.|        :.|:.
  Fly   436 SVEYPAKVTFTPTVQYLPFRLAGV-VQCYIKSSPQLQYVTWTKDKRLLEPYQ--------MKDIV 491

  Fly   441 LTSRISIGDAKLSD--SGNYSC----------SLGRLFTVIVQVQVLTGELPAAVQHNIGSRTEI 493
            :.:..|:...::::  .|.|:|          :.|.:..::.:....|.|.....|..:|...|:
  Fly   492 VMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEM 556

  Fly   494 YSLAM 498
            :..|:
  Fly   557 HCDAL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	24/99 (24%)
		Ig	<258..326	CDD:299845	22/84 (26%)
		IGc2	<417..461	CDD:197706	12/58 (21%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	16/117 (14%)
		IG_like	137..229	CDD:214653	12/91 (13%)
		I-set	253..341	CDD:254352	28/104 (27%)
		IGc2	268..331	CDD:197706	16/76 (21%)
		I-set	346..437	CDD:254352	21/91 (23%)
		Ig	349..437	CDD:299845	21/88 (24%)
		Ig	459..530	CDD:299845	14/79 (18%)
		IG_like	549..628	CDD:214653	3/13 (23%)
		IGc2	551..617	CDD:197706	3/11 (27%)
		FN3	633..725	CDD:238020
		FN3	786..874	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810