DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and itgb4

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	392	Identity:	79/392 - (20%)
Similarity:	128/392 - (32%)	Gaps:	126/392 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VIGSQVQVLYTTSVETKSPSASEQSRNGENRSLLFDDYNKTKSTLSTA--------DYLSA---- 93
            |:..|...::|....:.:.|..:...|...:..:.:| .:.:.|.|||        ||:|.
Zfish   984 VLKEQASSVFTFLEPSYTYSRQDGVANIPIKRQIIED-GRAQVTYSTADLTAKDKKDYISVDGDL 1047

  Fly    94 ----------TRATLYAFSSQD---QDEDHSQMPIEASNAPHSPIPTKMSR-GKIP------MET 138
                      ....|.....||   :|:...|..::.:|      |.:.:: |:.|      .:.
Zfish  1048 SYGAGETEKIVPVKLLELGEQDGLLEDKQVKQFVMDLTN------PRQSAKLGRYPRTVITIADK 1106

  Fly   139 PGS--MEFSSNSLPIKNVGTTDQLTTVTMPTTAFASLKVDRSTMKQPIDSTRTRN-----HWTAS 196
            |.|  |.|..::   :...|||.|.|:                   |::.|..|.     ||..:
Zfish  1107 PESSVMAFKKST---QTFSTTDSLYTI-------------------PVERTGNRETPATVHWRTN 1149

  Fly   197 GFAR-----------------VTERPRSKHHHEHHWGPFFEEPIN--SATSGDNLVSAVHLFTEA 242
            ..:|                 :...||:      |..|...|..|  .....:|.:......||.
Zfish  1150 KASRFDISSPLKFAPGEAEKNILINPRT------HPSPIIPEKFNLELLDPSNNAIIGKRKTTEV 1208

  Fly   243 VLNCRVGMLKD---KTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLINPTQT--- 301
            ::....|..|:   :.:.:|.:||     .:.|...|| ...|:.....|.|.||...|:|.
Zfish  1209 IVTDGRGDGKNQDFQKMEYVTQTA-----TSPGGRLYS-PANIKAVATGPKNIRLNWKPSQNANG 1267

  Fly   302 -----------EDAGVYMCQVSTHPPRVFTTNLTVLEPPLRIIDEHERDVGDRYYKSGSTVD-LQ 354
                       ||...:| .|.|  |:...||   |:|   ..|...|..|......|:..| :|
Zfish  1268 YKVKYWIYGDPEDKAKFM-DVKT--PQAELTN---LDP---YCDYEMRVCGYNALGDGNYSDIIQ 1323

  Fly   355 CQ 356
            ||
Zfish  1324 CQ 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	23/99 (23%)
		Ig	<258..326	CDD:299845	21/81 (26%)
		IGc2	<417..461	CDD:197706
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344	12/73 (16%)
		FN3	1242..1326	CDD:238020	25/93 (27%)
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900