DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	75/429 - (17%)
Similarity:	133/429 - (31%)	Gaps:	140/429 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LYTTSVETKSPSA-----SEQSRNGENRSLLFDDYNKTKSTLSTADYLSATRATLYAFSSQDQDE 108
            ||.:.|:.:...:     ::...:||.|       ....:.||..|...:....|..|.||:...
  Rat   240 LYISDVQKEDALSTYRCITQHKYSGETR-------QSNGARLSVTDPAESIPTILDGFHSQEVWT 297

  Fly   109 DHS-QMPIEASNAPHSPIPTKMSRGKIPMETPGSMEFSSNSLPIKNVGTTDQLTTVTMPTTAFAS 172
            .|: ::|..||..|...|........:|.::..:...:  .|.|.::.|.|..|.:...|..|.|
  Rat   298 GHAVELPCAASGYPIPAIRWLKDGRPLPADSRWAKRIT--GLTISDLRTEDSGTYICEVTNTFGS 360

  Fly   173 LKVDRSTMKQPIDSTRTRNHWTASGFARVTERPRSKHHHEHHWGPFFEEPINSATSGDNLVSAVH 237
            .:                    |:|...|.                  :|::...:...|.:.:.
  Rat   361 AE--------------------ANGVLTVI------------------DPLHVTLTPKKLKTGIG 387

  Fly   238 LFTEAVLNCRVGMLKDKTVMWVRRT-----AEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLIN 297
              :..:|:|.:....:.|:.|.|.|     .|.:|:..:.|.|                  |||:
  Rat   388 --STVILSCALTGSPEFTIRWYRNTELVLPGEAISIRGLSNET------------------LLIS 432

  Fly   298 PTQTEDAGVYMCQVSTHPPRVFTTNLTVLEPPL-RIIDEHERDVGDRYYKSGSTVDLQCQISRSF 361
            ..|...:|.|.|..:..........:.|||... ||:.    ...::....|....|.|
  Rat   433 SAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIVS----SFSEKVVNPGEQFSLMC------ 487

  Fly   362 FQKERQTILKSTDSANDAVQKLINETTSELNLIGNVNQTQHKFSGQDLEKYFTKFITWAKDEEPL 426
                         :|..|....                                 :|||.|:||:
  Rat   488 -------------AAKGAPPPT---------------------------------VTWALDDEPV 506

  Fly   427 ----QGMTNRRLSVSDVWLTSRISIGDAKLSDSGNYSCS 461
                ...|| :.::||....|.:::...::.|.|.|.|:
  Rat   507 VRDGSHRTN-QYTMSDGTTISHMNVTGPQIRDGGVYRCT 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	17/87 (20%)
		Ig	<258..326	CDD:299845	14/72 (19%)
		IGc2	<417..461	CDD:197706	14/47 (30%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652
		IGc2	101..168	CDD:197706
		Ig	183..276	CDD:299845	7/42 (17%)
		IG_like	195..276	CDD:214653	7/42 (17%)
		I-set	291..369	CDD:254352	19/99 (19%)
		IGc2	298..359	CDD:197706	13/62 (21%)
		IGc2	386..447	CDD:197706	17/80 (21%)
		I-set	466..560	CDD:254352	22/136 (16%)
		Ig	466..556	CDD:299845	22/136 (16%)
		IGc2	577..635	CDD:197706
		IG_like	665..744	CDD:214653
		Ig	673..739	CDD:143165
		I-set	748..843	CDD:254352
		Ig7_DSCAM	765..843	CDD:143211
		I-set	849..942	CDD:254352
		Ig	861..949	CDD:299845
		FN3	945..1039	CDD:238020
		FN3	1046..1143	CDD:238020
		fn3	1151..1237	CDD:278470
		FN3	1249..1340	CDD:238020
		IGc2	1364..1428	CDD:197706
		FN3	1442..1532	CDD:238020
		FN3	1546..1618	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810