DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and Kirrel2

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	341	Identity:	73/341 - (21%)
Similarity:	113/341 - (33%)	Gaps:	110/341 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 FFEEPINSATSGDNLVSAVHLFTEAVLNCRVGMLKDKTVMWVR--------RTAEKVSLLTVGNV 274
            |.::|       :::|  |.|..||.|.|.:|..:. .|.|.:        |.....|...:...
Mouse    23 FLQQP-------EDMV--VLLGEEARLPCALGAYRG-LVQWTKDGLALGGERDLPGWSRYWISGN 77

  Fly   275 TYSGDPRIRVKFQYPNNWRLLINPTQTEDAGVYMCQVSTHPPRVFTTNLTVLEPP--LRIIDEHE 337
            :.||...:.:|            |.:.||...|.||.|....|.....|.|:.||  .:::....
Mouse    78 SASGQHDLHIK------------PVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPS 130

  Fly   338 -------------RDVGDR-------YYKSGSTVDLQCQISRSFFQKERQTILKSTDSANDAVQK 382
                         |..||.       :::.|..:|     ..||    .||.||  |.|...|:.
Mouse   131 VSLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLD-----GSSF----HQTTLK--DKATGTVEN 184

  Fly   383 LINETTSE----LNLIGNVNQTQHKFSGQD----LEKYFTKFIT--------------------- 418
            .:..|.|.    ..||... ::|...:|:|    |...:...:|
Mouse   185 TLFLTPSSHDDGATLICRA-RSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQAT 248

  Fly   419 ---------WAKDEEPLQGMTNRRLSV--SDVWLTSRISIGDAKLSDSGNYSCSLGRLFTVIVQV 472
                     |||...|:.|....||.|  ...:||..:|...:....|.|.|.:|..|:..|:|.
Mouse   249 AQPPVTGYRWAKGGSPVLGARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQA 313

  Fly   473 QVLTGELPAAVQHNIG 488
            :      |.:|..::|
Mouse   314 K------PKSVSVDVG 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	20/90 (22%)
		Ig	<258..326	CDD:299845	15/75 (20%)
		IGc2	<417..461	CDD:197706	15/75 (20%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	25/110 (23%)
		Ig	122..220	CDD:416386	22/109 (20%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	1/6 (17%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	0/4 (0%)
		Ig strand C'	161..163	CDD:409353	1/1 (100%)
		Ig strand D	166..173	CDD:409353	3/10 (30%)
		Ig strand E	180..188	CDD:409353	1/7 (14%)
		Ig strand F	197..205	CDD:409353	2/8 (25%)
		Ig strand G	211..217	CDD:409353	2/5 (40%)
		Ig_3	223..292	CDD:404760	12/68 (18%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	0/3 (0%)
		Ig strand E	272..275	CDD:409353	2/2 (100%)
		Ig strand F	281..290	CDD:409353	3/8 (38%)
		Ig strand G	298..301	CDD:409353	1/2 (50%)
		Ig	315..392	CDD:416386	3/9 (33%)
		Ig strand A'	316..321	CDD:409353	1/4 (25%)
		Ig strand B	324..333	CDD:409353	73/341 (21%)
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900