DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr18 and Sdk2

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	565	Identity:	109/565 - (19%)
Similarity:	182/565 - (32%)	Gaps:	181/565 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SQVQVLYTTSVETKSPSASEQSRNGENRSLL---------------FDDYNKTKSTLSTADYLSA 93
            ::|||.|..|.|   .....||.|....:::               |.|..|...:...|..|..
Mouse   109 TEVQVAYMGSFE---EGEKRQSVNHGEAAVIRAPRISSFPRPQVTWFRDGRKIPPSSRIAITLEN 170

  Fly    94 T------------RATLYAFSSQDQDEDHSQ---MPIEASNAPHSPI-PTKMSRGKIPMETPG-- 140
            |            |..:.|.:.::.|...||   :.:|....|..|| ||.:...|......|
Mouse   171 TLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPKNTSVVAGTS 235

  Fly   141 --SMEFSSNSLPI---------------KNVGTTDQLTTVTMPTTAFASL----KVDRSTMKQPI 184
              :||..:|:.|:               ..:...::..|:..||.:.|..    .:.||:...|:
Mouse   236 EVTMECVANARPLIKLHIVWKKDGAPLSSGISDYNRRLTIANPTVSDAGYYECEAMLRSSSVAPV 300

  Fly   185 DSTRTRNHWTASGFARVTERPRSKHHHEHHWGPFFEEPINSATSGDNLVSAVHLFTEAVLNCRVG 249
                     |...:..|.|.|:.....|.|.....|:.::                   :.||..
Mouse   301 ---------TRGAYLSVLEPPQFVREPERHITAEMEKVVD-------------------IPCRAK 337

  Fly   250 MLKDKTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLINPTQTEDAGVYMC----- 309
            .:...::.|.:..|    |:.||.:|         :|:..::..|.|:....:|.|:..|
Mouse   338 GVPPPSITWYKDAA----LVEVGKLT---------RFKQRSDGGLQISGLLPDDTGMLQCFAHNA 389

  Fly   310 ----QVSTHPPRVFTTNL--TVLEPPL--RIIDEHE----------------RDVGDRYYKSGST 350
                |.||:   :..|::  .:...||  .:||...                ...|:|...|||.
Mouse   390 AGEAQTSTY---LAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSV 451

  Fly   351 VDLQCQISRSFFQKERQTILKSTDSANDA--------VQKLINETTSEL-----NLIGNVNQTQH 402
                 |:.| |...|..::|.|....:||        ..:.::|.:::|     ..|....|.|.
Mouse   452 -----QLPR-FTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQS 510

  Fly   403 KFSGQDL--------EKYFTKFITWAKDEEPLQGMTNRR--------LSVSDVWLTSRISIGDAK 451
            ...|...        :...|....|.||...|...||.|        |.:|..|
Mouse   511 VIKGTQASMVCGVTHDPRVTVRYVWEKDGATLAVETNPRIRLDRNGSLHISQTW----------- 564

  Fly   452 LSDSGNYSC---SLGRLFTVIVQVQVLTGELPAAVQHNIGSRTEI 493
            ..|.|.|:|   |.|...:....::|  .:||.|.:|.:.:.:.:
Mouse   565 SGDIGTYTCRVLSAGGNDSRNAHLRV--RQLPHAPEHPVATLSTV 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	18/93 (19%)
		Ig	<258..326	CDD:299845	16/78 (21%)
		IGc2	<417..461	CDD:197706	14/54 (26%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653	1/3 (33%)
		IGc2	44..102	CDD:197706
		IG_like	124..207	CDD:214653	14/82 (17%)
		Ig	136..192	CDD:299845	8/55 (15%)
		IG_like	226..308	CDD:214653	14/90 (16%)
		IGc2	237..290	CDD:197706	8/52 (15%)
		I-set	312..401	CDD:254352	21/123 (17%)
		Ig	330..398	CDD:143165	16/99 (16%)
		I-set	406..496	CDD:254352	19/95 (20%)
		Ig	420..496	CDD:299845	15/81 (19%)
		Ig	506..590	CDD:299845	20/94 (21%)
		IG_like	506..590	CDD:214653	20/94 (21%)
		FN3	594..685	CDD:238020	3/14 (21%)
		FN3	697..790	CDD:238020
		FN3	798..894	CDD:238020
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810