DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr18 and DSCAM

DIOPT Version :9

Sequence 1:NP_573102.1 Gene:dpr18 / 32572 FlyBaseID:FBgn0030723 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:613 Identity:120/613 - (19%)
Similarity:206/613 - (33%) Gaps:209/613 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 YRTLSPASNAAQTLPLSYNSQTSLSLLRLLTIALVIGSQVQV-----LYTTSVE----------- 55
            ::.:.|:|..|....:|:...         |::||.||:..:     ||...|:           
Human   143 FKCIIPSSVEAYITVVSWEKD---------TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCI 198

  Fly    56 TKSPSASEQSRNGENRSLLFDDYNKTKSTLSTADYLSATRATLYAFSSQDQDEDHSQMPIEASNA 120
            |:.....|..::...|..:.|..|...|.|...|:..|...            ...::|.:|...
Human   199 TRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAG------------QRVELPCKALGH 251

  Fly   121 PHSPIPTKMSRGKIPMETPGSMEFSSNSLPIKNVGTTDQLTTVTMPTTAFASLKV-DRSTMKQPI 184
            |....  :..:..:|:|..|..:.:...|.|:|:..:|..:.|...:..:.:.|| .|..:|||:
Human   252 PEPDY--RWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPL 314

  Fly   185 DSTRTRNHWTASGFARV--------TERPRSKHHHEHHW---GPFFEEPINSATSG---DNLV-- 233
            .:|.:.....:|..::|        ||      ..|..|   |.......|...:|   :||:  
Human   315 KATISPRKVKSSVGSQVSLSCSVTGTE------DQELSWYRNGEILNPGKNVRITGINHENLIMD 373

  Fly   234 ----------------------------------SAVHLFTEAV--------LNCRVGMLKDKTV 256
                                              ..:..|:|.|        |.|.|......|:
Human   374 HMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTI 438

  Fly   257 MW-------VRRTAEKVS--LLTVGNVTYSGDPRIRVKFQYPNNWRLLINPTQTEDAGVYMCQVS 312
            .|       ::..:.::|  :.:.|||.           .|.|     |:.:|..|.|||.|..:
Human   439 TWTLDDDPILKGGSHRISQMITSEGNVV-----------SYLN-----ISSSQVRDGGVYRCTAN 487

  Fly   313 THPPRV-FTTNLTVLEP----PLRIIDE--------HERDVGDRY-----YKSGSTVDL-QCQIS 358
            .....| :...:.|..|    |::.|..        |.|.:|..|     ||:.:.:.. ..|::
Human   488 NSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVA 552

  Fly   359 RSFFQKERQTILKSTDSANDAVQKLINETTSELNLIG----NVNQTQH---------------KF 404
                 .|....||.:|     |||.::|.....|::.    :.:|:.|               :|
Human   553 -----FENNGTLKLSD-----VQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRF 607

  Fly   405 S-GQ-----------DLEKYFTKFITWAKDEEPLQGMTNRRLSVSDVWLTSRISIGDAKLSDSGN 457
            | ||           ||.  .|  |||.||..|:.|...  :::.::..||.:.|.:..|..:||
Human   608 SIGQRVFIPCVVVSGDLP--IT--ITWQKDGRPIPGSLG--VTIDNIDFTSSLRISNLSLMHNGN 666

  Fly   458 YSCSLGRLFTVIVQVQVLTGELPAAVQH 485
            |:|              :.....|||:|
Human   667 YTC--------------IARNEAAAVEH 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr18NP_573102.1 IG_like 242..325 CDD:214653 20/100 (20%)
Ig <258..326 CDD:299845 15/77 (19%)
IGc2 <417..461 CDD:197706 14/43 (33%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273
I-set 235..310 CDD:254352 15/88 (17%)
I-set 315..385 CDD:333254 12/75 (16%)
Ig_3 407..488 CDD:316449 21/96 (22%)
IGc2 518..575 CDD:197706 15/66 (23%)
I-set 596..686 CDD:333254 26/105 (25%)
Ig_DSCAM 707..784 CDD:143211
Ig 802..889 CDD:325142
FN3 885..978 CDD:238020
FN3 986..1083 CDD:238020
FN3 1091..1184 CDD:238020
FN3 1189..1278 CDD:238020
Ig 1303..1369 CDD:319273
FN3 1380..1470 CDD:238020
FN3 1486..1555 CDD:238020
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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